Abstract：
BACKGROUND:Cruciferous vegetable consumption is inversely related to the incidence of prostate cancer. We examined the effect of indole-3-carbinol (I3C) and of sulforaphane (constituents of cruciferous vegetables) on cell proliferation of a PC-3 prostate cancer cell line, in order to observe if an inhibitory effect might be detected in vitro. METHODS:PC-3 prostate cancer cells were cultured in 96-well microtitre plates. Indole-3-carbinol concentrations ranging from 0.1 mmol/L to 0.8 mmol/L or sulforaphane concentrations ranging from 0.01 mmol/L to 0.06 mmol/L were added to the wells. Cell proliferation was measured by colorimetric assay and results were based on the mean value of triplicate experiments. Data are -presented as medians and interquartile ranges and were analysed using the Mann-Whitney U-test. RESULTS:Cell proliferation in PC-3 prostate cancer cells was significantly inhibited by I3C and sulforaphane at media concentrations of 0.2 mmol/L and 0.02 mmol/L, respectively. CONCLUSION:Both compounds inhibited the proliferation of prostate cancer cells in a dose-dependent manner. These findings may help explain the observed protective effect of cruciferous vegetables in relation to prostate cancer.
journal_name
ANZ J Surgjournal_title
ANZ journal of surgeryauthors
Frydoonfar HR,McGrath DR,Spigelman ADdoi
10.1046/j.1445-2197.2003.02652.xkeywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
154-6issue
3eissn
1445-1433issn
1445-2197pii
2652journal_volume
73pub_type
杂志文章abstract：BACKGROUND:Acute Appendicitis is the most common surgical presentation within Australia. Despite the increasing use of radiological investigations to aid clinical diagnosis, many appendectomies result in a histologically normal appendix. This study examines the histological negative appendicectomy rate (NAR) in a metro...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
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更新日期：2020-08-17 00:00:00
abstract：BACKGROUND:Human facial allotransplantation (FA) is a testament to the impressive progress, which was and is still happening in the field of transplantation medicine and reconstructive surgery. Like every pioneering treatment option, FA faces both the clinicians' and public opinion with a huge amount of medical and psy...
journal_title：ANZ journal of surgery
pub_type： 杂志文章,评审
doi：10.1111/j.1445-2197.2009.05140.x
更新日期：2009-12-01 00:00:00
abstract：AIM:To examine the outcomes and complications of surgery for recurrent carotid stenosis. METHODS:From 1974 to 2000, 1922 carotid endarterectomies were performed in our unit. A retrospective cohort analysis of these records identified 24 patients (1.2%) who underwent surgery for recurrent stenosis. RESULTS:There were ...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1046/j.1445-2197.2003.t01-8-.x
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:Assessing the role of laparoscopy in the management of intussusception. METHODS:A retrospective review of children aged up to 17 years who had surgery for intussusception at this institution between 1 January 2004 and 31 December 2013. RESULTS:The cohort of 44 individuals (18 females) presented at a median...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.13435
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:The correlation of post-operative serum albumin level with the occurrence of anastomotic leakage (AL) in oesophageal squamous cell carcinoma (ESCC) remains unclear. The aim of this study was to evaluate the impact of post-operative serum albumin level on AL after transthoracic oesophagectomy. METHODS:Patien...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
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abstract：:Acquired tracheo-oesophageal fistula is a devastating condition, usually occurring as a late manifestation of oesophageal or other thoracic malignancies. In these cases palliation by placement of an oesophageal stent is the preferred option, but management of a large non-malignant fistula is more complex. In many pati...
journal_title：ANZ journal of surgery
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abstract：BACKGROUND:Trastuzumab increases disease-free and overall survival in HER-2-positive, early breast cancer. In 2007, the National Breast and Ovarian Cancer Centre recommended that patients with HER-2 positive cancers (node positive or node negative tumours >1 cm) be offered adjuvant trastuzumab with chemotherapy. The ai...
journal_title：ANZ journal of surgery
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journal_title：ANZ journal of surgery
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更新日期：2021-01-21 00:00:00
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更新日期：2003-12-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
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更新日期：2015-07-01 00:00:00
abstract：:Abdominal Compartment Syndrome (ACS) is an increasingly recognized syndrome of intra-abdominal hypertension and generalized physiological dysfunction in critically ill patients. Patients suffering a ruptured abdominal aortic aneurysm (rAAA) are at risk of developing ACS. The objective of the study was to compare the c...
journal_title：ANZ journal of surgery
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更新日期：2008-08-01 00:00:00
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journal_title：ANZ journal of surgery
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更新日期：2014-10-01 00:00:00
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journal_title：ANZ journal of surgery
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更新日期：2015-06-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
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更新日期：2017-12-01 00:00:00
abstract：:This paper examines the career of Johann Sebastian Bach (1685-1750) and the role played by Wilhelm His I (who was, with Albert von Haller, a noted pioneer of physiology) in the exhumation of Bach's remains in 1894. His's examination of these remains allowed the sculptor Carl Seffner to produce the celebrated statue of...
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pub_type： 传,历史文章,杂志文章
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pub_type： 杂志文章,多中心研究
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2010.05606.x
更新日期：2011-07-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 历史文章,杂志文章
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更新日期：2009-12-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
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更新日期：2007-06-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.15495
更新日期：2019-12-01 00:00:00
