Abstract:
:Human plasma kallikrein (huPK) is a serine proteinase involved in many biological processes including those of the kallikrein-kinin system. The action of huPK on kininogen results in bradykinin (BK) release, a potent mediator of inflammatory responses. BK generation may be influenced by several agents, and the aim of this work was to investigate the effect of glycosaminoglycans (GAGs) on human high-molecular-weight kininogen (HK) hydrolysis by huPK and on inflammation. huPK was pre-incubated in the absence and presence of different GAGs, followed by the addition of kininogen. Bradykinin released at different times was measured by radioimmunoassay, and KM and kcat were calculated. Tuna and bovine dermatan sulfates, the most potent GAGs studied, reduced by 80% and 68%, respectively, the catalytic efficiency of huPK (control = 4. x 10(4) M(-1) s(-1) in BK release. The effect of bovine dermatan sulfate (BDS) on inflammatory response was studied in rat paw edema induced by carrageenin and hourly determined (1-4 h) by plethysmography. BDS significantly reduced the inflammatory response in the first and second hours of measurements (24% and 28%, respectively), p < 0.05. GAGs were shown to reduce bradykinin release "in vitro" and in an inflammation model. This reduction may play a role in the control or maintenance of some pathological and physiological processes.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Gozzo AJ,Nunes VA,Carmona AK,Nader HB,von Dietrich CP,Silveira VL,Shimamoto K,Ura N,Sampaio MU,Sampaio CA,Araújo MSdoi
10.1016/s1567-5769(02)00145-5keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
1861-5issue
13-14eissn
1567-5769issn
1878-1705pii
S1567-5769(02)00145-5journal_volume
2pub_type
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