Abstract:
:The aim was to validate possible vasodilating effects of a Ginkgo biloba extract with a secondary aim of finding a pharmacodynamic signal relating to the active component of these extracts. We studied the effect of G. biloba extract on forearm haemodynamics in 16 healthy subjects (nine females, seven males) with a median age of 32 years (range: 21-47). The study was conducted as a randomized, double-blinded cross-over design using oral treatment with G. biloba extract (Gibidyl Forte(R) t.i.d. or placebo for 6 weeks. Forearm blood flow and venous capacity were measured by strain-gauge plethysmography. Blood pressure was measured by standard sphygmomanometry, and forearm vascular resistance (FVR) was derived. Measurements were made at baseline and after 3, 6, 9 and 12 weeks of treatment. Forearm blood flow was significantly higher during active treatment after 3 and 6 weeks as compared with placebo treatment for 3 and 6 weeks (P<0.05). Mean arterial blood pressure was unchanged, making the calculated FVR significantly lower during active treatment (P<0.02). It is concluded that oral treatment with a G. biloba extract (Gibidyl Forte(R)) is able to dilate forearm blood vessels causing increments in regional blood flow without changing blood pressure levels in healthy subjects. The increments in blood flow may be used as a biological signal for pharmacokinetic studies.
journal_name
Clin Physiol Funct Imagingjournal_title
Clinical physiology and functional imagingauthors
Mehlsen J,Drabaek H,Wiinberg N,Winther Kdoi
10.1046/j.1475-097x.2002.00445.xkeywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
375-8issue
6eissn
1475-0961issn
1475-097Xpii
445journal_volume
22pub_type
临床试验,杂志文章,随机对照试验abstract::Given the important role of the shoulder sensorimotor system in shoulder stability, its assessment appears of interest. Force platform monitoring of centre of pressure (CoP) in upper-limb weight-bearing positions is of interest as it allows integration of all aspects of shoulder sensorimotor control. This study aimed ...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2012.01140.x
更新日期:2012-09-01 00:00:00
abstract::Computerized lung sounds analysis offers a new technique to monitor regional ventilation during spontaneous breathing. The purpose of the present study was to assess the acoustic behaviour of the respiratory system in healthy pigs during mechanical ventilation when a positive end-expiratory pressure (PEEP) is applied....
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2005.00652.x
更新日期:2006-01-01 00:00:00
abstract::We investigated whether a single 60-min bout of whole leg, peristaltic pulse external pneumatic compression (EPC) altered select growth factor-related mRNAs and/or various phospho(p)-proteins related to cell growth, proliferation, inflammation and apoptosis signalling (e.g. Akt-mTOR, Jak-Stat). Ten participants (8 mal...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12343
更新日期:2017-11-01 00:00:00
abstract::Bone Scan Index (BSI) is a validated imaging biomarker to objectively assess tumour burden in bone in patients with prostate cancer, and can be used to monitor treatment response. It is not known if BSI is significantly altered when images are acquired at a time difference of 1 h. The aim of this study was to investig...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12518
更新日期:2018-04-06 00:00:00
abstract::Tracers for myocardial perfusion imaging during stress should not only have high cardiac uptake but they should also have a fast blood clearance to prevent myocardial tracer uptake after the ischaemic stimulus. The present study characterize the early phase of the arterial (99m)Tc-sestamibi (MIBI) time-activity curve ...
journal_title:Clinical physiology and functional imaging
pub_type: 临床试验,杂志文章
doi:10.1111/j.1475-097X.2004.00570.x
更新日期:2004-11-01 00:00:00
abstract::Sixty percent of stroke volume (SV) is generated by atrioventricular plane displacement (AVPD) in a healthy left ventricle (LV). The aims were to determine the effect of ST-elevation myocardial infarction (STEMI) on AVPD and contribution of AVPD to SV and to study the relationship between AVPD and infarct size (IS) an...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12521
更新日期:2018-04-27 00:00:00
abstract::Patients with nemaline myopathy, a muscle disorder primarily affecting the thin filaments, suffer from weakness which is poorly understood. As disturbed excitation-contraction coupling has been suggested as a possible mechanism, the present study was designed to investigate whether the contractile properties of the kn...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2007.00740.x
更新日期:2007-07-01 00:00:00
abstract::Cirrhotic cardiomyopathy (CCM) is characterized by an impaired contractile response to stress, diastolic dysfunction and the presence of electrophysiological abnormalities, and it may be diagnosed at rest in some patients or demasked by physiological or pharmacological stress. CCM seems to be involved in the developme...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章,评审
doi:10.1111/cpf.12311
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterized by inflammation of the lung in association with airflow obstruction. There is increasing evidence of upper airway involvement in COPD and we have reported that this nasal inflammation is proportional to that in the lung. Given recognized relations...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2006.00683.x
更新日期:2006-07-01 00:00:00
abstract::There is no general agreement on the spirometric definition of chronic obstructive pulmonary disease (COPD). The global initiative for obstructive lung disease recommends a fixed ratio between forced expiratory volume in one-second (FEV1 ) and forced vital capacity (FVC) of <0·7 (FR) for the diagnosis of COPD. Europea...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12294
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:The heat-washout method is an objective method that measures cutaneous blood flow rate (BFR) in ml (100 g. min)(-1), previously found useful for measuring toe BFR in non-diabetic patients with claudication. AIM:The method is used for evaluating the presence of a veno-arteriolar reflex (VAR) in the forefoot ...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12028
更新日期:2013-07-01 00:00:00
abstract::During recent years, the radial movement of the arterial wall has been extensively studied, and measurements of the radial movement are now an important tool in cardiovascular research for characterizing the mechanical properties of the arterial wall. In contrast, the longitudinal movement of vessels has gained little...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1046/j.1475-097x.2003.00504.x
更新日期:2003-09-01 00:00:00
abstract::Grey scale median (GSM) measured on ultrasound images of carotid plaques has been used for several years now in research to find the vulnerable plaque. Centres have used different software and also different methods for GSM measurement. This has resulted in a wide range of GSM values and cut-off values for the detecti...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12049
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:The assessment of temporal changes in systolic and diastolic regional left ventricle function by two-dimensional speckle tracking echocardiography (STE) after successful reperfusion therapy of acute myocardial infarction (AMI). METHODS:A total of 97 consecutive patients admitted with AMI and treated with succe...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12553
更新日期:2019-03-01 00:00:00
abstract:AIM:Obstructive sleep apnoeas generate an intense afferent traffic leading to arousal and apnoea termination. Yet a decrease in the sensitivity of the afferents has been described in patients with obstructive sleep apnoea, and could be a determinant of disease severity. How mechanical changes within the respiratory sys...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2008.00830.x
更新日期:2009-01-01 00:00:00
abstract::Previous studies have indicated that, during mechanical ventilation, an inspiratory pause enhances gas exchange. This has been attributed to prolonged time during which fresh gas of the tidal volume is present in the respiratory zone and is available for distribution in the lung periphery. The mean distribution time o...
journal_title:Clinical physiology and functional imaging
pub_type: 临床试验,杂志文章
doi:10.1111/j.1475-097X.2007.00699.x
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:We investigated if image- and diagnostic quality in SPECT MPI could be maintained despite a reduced acquisition time adding Depth Dependent Resolution Recovery (DDRR) for image reconstruction. Images were compared with filtered back projection (FBP) and iterative reconstruction using Ordered Subsets Expect...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12354
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The use of radioactive compounds for sentinel node biopsy is now a generally accepted part of the surgical treatment of breast cancer and melanoma, with the risk of radiation exposure to the operating team. The aim of this investigation was to study the levels of this exposure in relation to the permissible ...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2005.00611.x
更新日期:2005-07-01 00:00:00
abstract::The aim of the study was to collect new reference values for the clinical ramp exercise test on bicycle, because in our experience, the commonly used values were too low. A group of healthy men (n = 81, 20-80 years) was randomly selected from the local municipal register to achieve an even distribution in age. Data we...
journal_title:Clinical physiology and functional imaging
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1475-097x.2003.00491.x
更新日期:2003-05-01 00:00:00
abstract::This study aimed to evaluate the effect of standard medical treatment on the progression of atherosclerosis after a myocardial infarction, in an ordinary clinical setting, by measuring the right and left common carotid intima-media thickness (IMT). The first investigation took place 3-12 months after the index event; ...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12101
更新日期:2014-07-01 00:00:00
abstract::The stroke volume (SV) during exercise is an important index of the heart's functional capacity. A new method has been developed for the non-invasive estimation of exercise SV (SVex). It requires the determination of the slope for the oxygen uptake versus heart rate relationship in the steady state of graded exercise ...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/j.1475-097X.2004.00585.x
更新日期:2005-01-01 00:00:00
abstract::The purpose of this state-of-the-art review was to examine the effects of exercise training on arterial stiffness (AS) in patients with coronary artery disease (CAD). A PubMed and SCOPUS literature search was conducted up to March of 2013. Two authors performed the selection of the studies and the subsequent data extr...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章,评审
doi:10.1111/cpf.12093
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:In MRI studies of carotid plaques, ultrasound is used to find plaques, which are later imaged using MRI. The performance in plaque detection has not been compared between the modalities. The aim of the current study was to compare the performance of MRI and ultrasound in detecting carotid artery plaques and ...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12415
更新日期:2018-03-01 00:00:00
abstract::Blood flow (BF) in exercising muscles is an important factor for exercise capacity. Recently, a non-invasive method to estimate capillary BF (Qcap ) was introduced. Using this method, the Fick principle is re-arranged by using relative differences in deoxygenated haemoglobin (ΔHHb) as a surrogate for arteriovenous O2 ...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12434
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:Notwithstanding recent progress on molecular mechanisms underlying heart failure with preserved ejection fraction (HFpEF), multiple pathophysiological aspects of this condition including the basis of anaemia and other haematological disorders remain unresolved. In this study, we sought to determine the rel...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12614
更新日期:2020-03-01 00:00:00
abstract::Atherosclerosis is a growing health challenge globally, and despite our knowledge of the disease has increased over the last couple of decades, many unanswered questions remain. As molecular imaging can be used to visualize, characterize and measure biological processes at the molecular and cellular levels in living s...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章,评审
doi:10.1111/cpf.12017
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To compare the hemodynamic response during resistance exercise at high intensity (HI), low intensity (LI) and low intensity with blood flow restriction (LI-BFR) in healthy subjects. METHODS:Twelve men performed three sets of unilateral knee extension exercises at LI-BFR and LI (15 repetitions; 20% of 1RM) and ...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章,随机对照试验
doi:10.1111/cpf.12218
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Autonomic dysfunction (AD) and cardiopulmonary exercise testing (CPET) parameters have been associated with masked heart failure with preserved ejection fraction (HFpEF) in the general population. Their clinical significance for masked HFpEF in chronic obstructive pulmonary disease (COPD) is however elusive....
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12623
更新日期:2020-07-01 00:00:00
abstract::The purpose of this study was to examine the effectiveness of maximal and rapid isometric torque characteristics of the hip extensor muscles and postural balance performance to discriminate between female collegiate soccer athletes and non-athlete controls. Ten athletes (mean ± SE: age = 19·20 ± 0·36 year; mass = 62·2...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章
doi:10.1111/cpf.12167
更新日期:2015-07-01 00:00:00
abstract::The purpose of this systematic review was to evaluate the effects of smokeless forms of nicotine on physiological responses and exercise performance. Methodology and reporting were based on the PRISMA statement. The intervention was defined as any product containing nicotine that did not require smoking. Searches were...
journal_title:Clinical physiology and functional imaging
pub_type: 杂志文章,评审
doi:10.1111/cpf.12443
更新日期:2018-07-01 00:00:00