Abstract：
:Many diseases, mainly infectious and inhalational, have been associated with the use of hot tubs. "Hot tub lung" is a recently described disease entity associated with Mycobacterium avium complex (MAC) and is thought to be either an infection or a hypersensitivity pneumonitis. We describe 2 patients with progressively worsening respiratory symptoms and pulmonary function, along with diffuse radiographic changes consisting primarily of ground-glass opacities. Treatment with corticosteroids, based on lung biopsies suggesting sarcoidosis in 1 patient and eosinophilic bronchiolitis in the other, resulted in little improvement with both patients experiencing respiratory failure. Both patients continued regular and continued hot tub use despite ongoing respiratory difficulties, and MAC was identified in the hot tub water and/or lung tissue from each patient. Discontinuation of hot tub use, without antimycobacterial therapy, led to prompt improvement in symptoms, pulmonary function, and radiographic abnormalities, strongly supporting a diagnosis of hypersensitivity pneumonitis. Hypersensitivity to MAC, rather than an infection, is the likely underlying mechanism in these 2 cases of hot tub lung.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Rickman OB,Ryu JH,Fidler ME,Kalra Sdoi
10.4065/77.11.1233keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
1233-7issue
11eissn
0025-6196issn
1942-5546pii
S0025-6196(11)61814-4journal_volume
77pub_type
杂志文章abstract：OBJECTIVE:To determine whether sirolimus therapy is associated with neurologic complications, including stroke, among heart transplant recipients. PATIENTS AND METHODS:We retrospectively studied patients who underwent heart transplant at Mayo Clinic's site in Rochester, MN, from January 1, 1988, through June 30, 2006....
journal_title：Mayo Clinic proceedings
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abstract：OBJECTIVE:To investigate the impact on cardiovascular events (CVEs) in a real-world population of patients with atrial fibrillation (AF) by implementing the Atrial fibrillation Better Care (ABC: A, Avoid stroke with anticoagulation; B, better symptom management; C, Cardiovascular and comorbidity risk management) pathwa...
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abstract：OBJECTIVE:To ascertain the incidence and timing of fever in patients at risk for temperature modulation of brain injury resulting from ischemia or trauma. DESIGN:We retrospectively reviewed the medical records of patients admitted between January 1991 and December 1994. MATERIAL AND METHODS:We investigated three grou...
journal_title：Mayo Clinic proceedings
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abstract：OBJECTIVE:To verify preliminary studies on patients with melanoma exposed to β-blockers that suggested a reduced risk of disease recurrence and death. PATIENTS AND METHODS:Data were obtained from all consecutive patients diagnosed as having melanoma between January 1, 1993, and December 31, 2009, at the Department of ...
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更新日期：1995-01-01 00:00:00
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更新日期：1977-10-01 00:00:00
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更新日期：1991-09-01 00:00:00
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doi：
更新日期：1978-07-01 00:00:00
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doi：
更新日期：1980-08-01 00:00:00
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pub_type： 临床试验,杂志文章,评审
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更新日期：1979-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2002-12-01 00:00:00
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更新日期：2020-08-01 00:00:00
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更新日期：2017-11-01 00:00:00
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更新日期：2012-03-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/75.12.1305
更新日期：2000-12-01 00:00:00
