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A mouse model of human L1 retrotransposition.

Abstract：

:The L1 retrotransposon has had an immense impact on the size and structure of the human genome through a variety of mechanisms, including insertional mutagenesis. To study retrotransposition in a living organism, we created a mouse model of human L1 retrotransposition. Here we show that L1 elements can retrotranspose in male germ cells, and that expression of a human L1 element under the control of its endogenous promoter is restricted to testis and ovary. In the mouse line with the highest level of L1 expression, we found two de novo L1 insertions in 135 offspring. Both insertions were structurally indistinguishable from natural endogenous insertions. This suggests that an individual L1 element can have substantial mutagenic potential. In addition to providing a valuable in vivo model of retrotransposition in mammals, these mice are an important step in the development of a new random mutagenesis system.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Ostertag EM,DeBerardinis RJ,Goodier JL,Zhang Y,Yang N,Gerton GL,Kazazian HH Jr

doi

10.1038/ng1022

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

655-60

issue

4

eissn

1061-4036

issn

1546-1718

pii

ng1022

journal_volume

32

pub_type

杂志文章

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