Abstract:
:Concern over endocrine disrupters in coastal ecosystems has stimulated global efforts to understand their potential impacts on fish and invertebrate communities. Given that marine crustaceans are sensitive to the effects of alkylphenols and other xenobiotics, we are currently investigating whether these responses may be caused via an endocrine mechanism. Tisbe battagliai (Copepoda: Harpacticoida) is representative of an ecologically important group of meiofauna, is sensitive to toxicants and is used as an international test species in marine ecotoxicology. A 21-day life-cycle test that incorporates assessment of survival, development, reproduction and sex ratios, has shown that populations of T. battagliai are not significantly affected by environmentally relevant levels of steroidal oestrogen agonists, or by related synthetic receptor agonists. The absence of in vivo effects due to these steroid agonists and antagonists prompted in vitro studies of ecdysteroid receptor activity of a range of reference compounds and environmental contaminants with an ecdysteroid receptor (EcR/USP)-based screening assay derived from the BII haemocyte line of Drosophila melanogaster. The implications for environmental monitoring of endocrine disrupters are discussed.
journal_name
Mar Environ Resjournal_title
Marine environmental researchauthors
Pounds NA,Hutchinson TH,Williams TD,Whiting P,Dinan Ldoi
10.1016/s0141-1136(02)00113-7keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
709-13issue
3-5eissn
0141-1136issn
1879-0291pii
S0141-1136(02)00113-7journal_volume
54pub_type
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