Abstract：
BACKGROUND:Angiosarcomas arise in the scalp and face in the elderly, in association with chronic lymphedema (Stewart-Treves syndrome), and in irradiated areas. Rarely in these settings, angiosarcomas exhibit pure spindle cell phenotype. METHODS:Herein, the clinicopathologic features of a 72-year-old-woman with spindle cell angiosarcoma are described. RESULTS:A 72-year-old woman presented with numerous nodules and diffuse induration from the lower abdomen to the right buttock, corresponding to the area exposed to 60Co-irradiation during treatment for cervical carcinoma 10 years earlier. Histopathological examination revealed inflitrative, atypical, spindle cells that labeled with antibodies to CD31, CD34, and factor VIII-related antigen. Ultrastructurally, these malignant spindle cells contained Weibel-Palade bodies. No features suggesting radiation dermatitis (sclerosis or bizarre, large fibroblasts) were identified, but lymphangiectases and widely spaced collagen bundles(lymphedema) were prominent in the skin surrounding the angiosarcoma. Computed tomographic scan of the abdomen highlighted this histologic finding by demonstrating tumor masses limited to areas of lymphedema. Treatment with intravenous and local injections of recombinant interleukin 2 (rIL 2) followed by electron beam irradiation were initially effective with tumor remission for 2 months. However, the recurrent tumor did not respond to a second course of one-shot injection of rIL 2 through the abdominal aorta and the patient succumbed to her angiosarcoma 19 months after diagnosis. CONCLUSIONS:Radiation-induced lymphedema may be a factor in angiosarcoma associated with radiotherapy.
journal_name
J Cutan Patholjournal_title
Journal of cutaneous pathologyauthors
Kiyohara T,Kumakiri M,Kobayashl H,Itoh K,Lao LM,Ohkawara A,Nakmura Hdoi
10.1034/j.1600-0560.2002.290206.xkeywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
96-100issue
2eissn
0303-6987issn
1600-0560journal_volume
29pub_type
杂志文章abstract：BACKGROUND:The present study evaluates the signal transducer and activator of transcription-3 (STAT-3) expression and activation in actinic cheilitis (AC) and the relationship of this protein with the degree of epithelial dysplasia. METHODS:Twenty-five cases of AC were analyzed. Normal lip mucosa was used as a control...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2006.00668.x
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor arising predominantly on sun-exposed skin of older and usually immunosuppressed individuals. METHODS:Using data from NCI's SEER (Surveillance, Epidemiology, and End Results) Program from 1973 to 2006, we analyzed the demographics and ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2009.01370.x
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:CD44 is a membrane glycoprotein and the major cell-surface receptor of hyaluronate (HA). Lack of CD44 expression in mouse epidermis leads to an abnormal HA accumulation in the dermis, indicating an important role of CD44 in local HA metabolism. Decrease of epidermal CD44 expression in patients of lichen scle...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.0303-6987.2006.00463.x
更新日期：2006-03-01 00:00:00
abstract：:Cutaneous immune-related adverse events (irAEs) are a known consequence of immune checkpoint inhibitor (ICI) therapy and may exhibit a spectrum of morphologic features both clinically and histologically. Lichenoid dermatitis associated with ICI therapy (LD-ICI) is the most frequently encountered histopathologic type o...
journal_title：Journal of cutaneous pathology
pub_type： 临床试验,杂志文章
doi：10.1111/cup.13536
更新日期：2019-11-01 00:00:00
abstract：:The low-fat and fat-free spindle cell lipomas (SCLs) are rare and often mistaken for other benign and malignant morphological mimics, because of the fact that the diagnosis relies on its non-lipogenic component analysis. Here, we report the clinicopathological features of two oral SCLs (low-fat and fat-free variants)....
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/cup.13512
更新日期：2019-10-01 00:00:00
abstract：:Oral melanoacanthoma is a rarely-reported, benign pigmented lesion of oral mucosa. Spongiosis was only recently mentioned as a light-microscopical finding occasionally seen in oral melanoacanthoma, and the formation of spongiotic intraepithelial vesicles to our knowledge has never been reported. The authors discuss a ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1989.tb00587.x
更新日期：1989-12-01 00:00:00
abstract：:Fundamental to our understanding of skin diseases and their presentation is an understanding of the pattern of their development. When we have established the molecular basis of their development we will be in a much better position to control and treat such diseases. The homeobox genes are a family of regulatory prot...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0560.1993.tb01264.x
更新日期：1993-08-01 00:00:00
abstract：:Mycosis fungoides in palmoplantar localization (MFPP) is a rare variant of MF that is confined to the hands and feet. Patients commonly receive treatment over many years for suspected palmoplantar dermatitis before the diagnosis is made. Most MFPP patients remain at patch or plaque stage, and often respond to treatmen...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13140
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:De novo intraepidermal epithelioid melanocytic dysplasia (DNIEMD) is a newly characterized lesion that is associated with a personal and/or family history of malignant melanoma (MM) and/or dysplastic nevi (DN). However, the biological significance is still uncertain and the persons predisposed to this lesion...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2009.01429.x
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:Changes in the clinical appearance of benign dermal nevi during pregnancy may be concerning for malignant transformation. Because the hormonal milieu of pregnancy has not proven to alter their banal behavior, histologic characterization is needed to prevent over-diagnosis and unnecessary treatment. METHODS:...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2009.01491.x
更新日期：2010-08-01 00:00:00
abstract：:Two cases of juvenile elastoma (nevus elasticus in disseminated tumors) were histologically and ultrastructurally investigated. The predominant components of this disseminated dysembryoplasia are abnormal elastic fibers. Both cases showed numerous large elastic fibers with an abundant background matrix. The elastic mi...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1981.tb01001.x
更新日期：1981-06-01 00:00:00
abstract：:Immunotherapies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have showed significant therapeutic benefit in patients with clinically advanced solid malignancies, including melanoma. However, immune-related adverse events (irAE) ar...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13150
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Chronic urticaria is a condition with many inciting factors and often presents a therapeutic challenge to clinicians. In addition to a central role for mast cells, an immune dysregulated state related to cytokine/chemokine alterations is increasingly being recognized. METHODS:Biopsies of chronic urticaria (...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12673
更新日期：2016-04-01 00:00:00
abstract：:Pleomorphic fibromas represent dome-shaped or polypoid cutaneous lesions characterized by a paucicellular and densely fibrotic background punctuated by scattered atypical to pleomorphic spindle and multinucleated giant cells. Some of these tumors will have incorporated adipose tissue, although these adipocytic areas l...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12095
更新日期：2013-04-01 00:00:00
abstract：:Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare cutaneous adnexal malignancy with predilection for the eyelids of older adults. It must be distinguished from metastatic adenocarcinomas of extracutaneous origin and from benign adnexal proliferations on partial samples when a solid growth component an...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.13831
更新日期：2021-01-01 00:00:00
abstract：:Large cell neuroendocrine carcinoma (LCNEC) of the larynx is an aggressive form of neuroendocrine carcinoma that affects smokers at an average age of 60 years. LCNEC is characterized by large cells with round to ovoid nuclei distributed in a trabecular or nested growth pattern. Previously, laryngeal LCNEC and atypical...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13090
更新日期：2018-03-01 00:00:00
abstract：:Although non-specific skin lesions are quite common in patients with leukemia, the specific infiltration of the skin by blast cells, known as leukemia cutis, is rare. Its incidence ranges from 1 to 50% and depends on the specific type of leukemia. Leukemic vasculitis represents a rare form of leukemia cutis consisting...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2010.01623.x
更新日期：2011-04-01 00:00:00
abstract：:We present a challenging case of chronic, erosive, scarring dermatosis of the vulva with clinical features of long standing lichen sclerosus (LS), namely pallor and loss of vulval architecture, but with histopathology consistently showing features of an acantholytic process. The history and clinical features of this c...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13560
更新日期：2020-01-01 00:00:00
abstract：:Carcinoembryonic antigen (CEA) is a well-established marker for sweat gland differentiation in adnexal neoplasms. In contrast to previous assumptions, CEA does not represent a single oncofetal antigen but comprises a family of homologous glycoproteins, i.e. the classical CEA-180, biliary glycoprotein (BGP), and non-sp...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1996.tb00770.x
更新日期：1996-02-01 00:00:00
abstract：BACKGROUND:Rhabdomyosarcoma is a malignant mesenchymal tumor with skeletal muscle differentiation. Primary cutaneous rhabdomyosarcoma is rare. We report a series of 11 cases of primary cutaneous rhabdomyosarcoma. METHODS:Cases diagnosed as rhabdomyosarcoma arising in the dermis/subcutis with no identified primary tumo...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12007
更新日期：2012-11-01 00:00:00
abstract：:Cutaneous lesions of lupus erythematosus (LE) show a broad spectrum of clinicopathologic features. Histopathologically, besides typical patterns such as interface dermatitis, perivascular lymphocytic infiltrate and dermal mucin deposits, an involvement of the eccrine structures, especially the acrosyringium, may be ob...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2009.01295.x
更新日期：2010-01-01 00:00:00
abstract：:Malignant mesothelioma (MM) is an aggressive and invasive neoplasm primarily affecting the pleura, peritoneum and pericardium. While mesothelioma commonly metastasizes to visceral organs, it has rarely been documented to involve the skin and subcutaneous tissue. There is a paucity of reports of cutaneous metastatic me...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13026
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neoplasm, which is often associated with Merkel cell polyomavirus (MCPyV). Programmed death-1 (PD-1) and its ligand PD-L1 are key players of the tumor microenvironment (TME). METHODS:Fourteen paraffin-embedded tissue samples of MCC were stratified by their MCPyV ...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12973
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Bullous pemphigoid (BP) is the most common type of subepidermal bullous disease. Direct immunofluorescence (DIF) is the gold standard for diagnosis, but it requires a fresh tissue specimen. This study was conducted to evaluate the accuracy of using immunohistochemical (IHC) analysis for the detection of C4d ...
journal_title：Journal of cutaneous pathology
pub_type： 临床试验,杂志文章
doi：10.1111/cup.13490
更新日期：2019-10-01 00:00:00
abstract：:The diagnosis of a CD30+ cutaneous infiltrate is often difficult and requires clinicopathologic correlation. To further evaluate this challenge, initial clinical and histopathologic diagnoses were correlated with final clinicopathologic diagnosis in 44 cases with CD30 immunopositivity. Dermatopathologic evaluation con...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/cup.12510
更新日期：2015-07-01 00:00:00
abstract：:Subungual melanoma commonly presents with solitary longitudinal melanonychia. Herein, we report the case of a patient with subungual melanoma who developed involvement of three digits by three independent primary melanomas. A 98-year-old male patient presented with a two-year history of longitudinal melanonychia on th...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2011.01799.x
更新日期：2012-02-01 00:00:00
abstract：:After intradermal testing with goldsodiumthiomalate (GSTM), 5 out of 8 patients developed skin papules at the test sites, which persisted up to 20 months. The lesions were surgically excised. Histology revealed pseudolymphoma of B and T cell type containing follicular structures and occasional small granulomas. The am...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.1996.tb01306.x
更新日期：1996-08-01 00:00:00
abstract：:Pigmented extramammary Paget disease (PEMPD) is a rare intraepithelial carcinoma which can clinically resemble other pigmented neoplasms. Similarities to melanoma on dermoscopy, histopathology, and reflectance confocal microscopy (RCM) increase the risk of misdiagnosis and, consequently, mismanagement. Here, we descri...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.13804
更新日期：2020-12-01 00:00:00
abstract：:A case of an osteogenic desmoplastic melanoma occurring on the sole of the foot of a 60-year-old African American man is described. The tumor measured 4.8 cm in greatest dimension, invaded to a thickness of 2.2 cm and metastasized to four of ten inguinal lymph nodes. The majority of the tumor had a classic desmoplasti...
journal_title：Journal of cutaneous pathology
pub_type： 杂志文章
doi：10.1111/j.1600-0560.2006.00634.x
更新日期：2007-05-01 00:00:00
abstract：:Until recently the number of patients with syphilis has been diminishing. Although that trend has reversed cases of tertiary syphilis are rare and often difficult to diagnose as a substantial number of patients will have a negative rapid plasma reagin. Histologically, cutaneous lesions in late stage syphilis exist in ...
journal_title：Journal of cutaneous pathology
pub_type：
doi：10.1111/cup.12770
更新日期：2016-11-01 00:00:00
