Impact of splenectomy on circulating T-lymphocyte subsets in stage III gastric cancer.

Abstract:

BACKGROUND:The role of splenectomy remains unclear in patients with gastric cancer who undergo total gastrectomy. The aim of this study was to prospectively evaluate the impact of splenectomy on circulating T-lymphocyte subsets and survival in advanced gastric cancer. METHODS:Analysis of lymphocyte subsets was performed in 40 patients with American Joint Committee on Cancer (AJCC) stage III gastric adenocarcinoma located on the upper one-third of the stomach, who underwent a curative total gastrectomy with or without splenectomy. Circulating T-lymphocyte subsets were measured on venous blood by using flow cytometry and monoclonal antibodies at preoperative day 1, and postoperative months 1, 3, 6, 12 and 18. RESULTS:The proportion of lymphocytes and the values of CD3, CD8, CD16 and CD25 subsets were higher in the splenectomy group of patients at postoperative month 3. In the spleen preservation group at the same point of treatment, the proportion of granulocytes and the values of CD4 and CD4 : CD8 ratio were higher. Except for CD16 levels, all T-lymphocyte subsets showed no significant difference between splenectomy and spleen preservation groups after postoperative month 3. Increased CD16 levels in the splenectomy group were not associated with improvement in patients' 5-year survival rates. CONCLUSION:These results suggest that the long-term impact of splenectomy does not play an important role in postoperative quantitative changes of circulating T-lymphocyte subsets of patients with stage III gastric cancer who have undergone total gastrectomy. Furthermore, splenectomy does not give a prognostic benefit, based on tumour recurrence and survival of patients with proximal one-third gastric cancer who undergo total gastrectomy.

journal_name

ANZ J Surg

journal_title

ANZ journal of surgery

authors

Cho MY,Kroh MD,Joh YG,Suh SO

doi

10.1046/j.1445-2197.2002.02429.x

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

411-6

issue

6

eissn

1445-1433

issn

1445-2197

pii

2429

journal_volume

72

pub_type

杂志文章
  • Acute cholecystitis or simple biliary colic after an emergency presentation: why it matters.

    abstract:BACKGROUND:Laparoscopic cholecystectomy (LC) is often performed during the index admission after emergency presentation for acute biliary pain. Many patients have acute cholecystitis (AC) that may increase operative difficulty and complications. Our primary aim was to assess the validity of Tokyo Guidelines (TG18) for ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.15603

    authors: Nguyen CL,van Dijk A,Smith G,Leibman S,Mittal A,Albania M,de Reuver P,Hugh TJ

    更新日期:2020-03-01 00:00:00

  • Influence of screw to joint distance on articular subsidence in tibial-plateau fractures.

    abstract:BACKGROUND:Tibial-plateau fractures with depressed osteochondral fragments have a high incidence of articular subsidence post reduction. Locking plates aim to prevent this via 'raft' screws below the subchondral bone. However, differences in plate design and patient anatomy result in variability of screw position in re...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.14978

    authors: Ye X,Huang D,Perriman DM,Smith PN

    更新日期:2019-04-01 00:00:00

  • Prospective comparison of return of bowel function after left versus right colectomy.

    abstract:BACKGROUND:Passage of flatus and stool represents a key milestone in recovery after colonic resections. Colorectal surgeons may hold varied expectations regarding recovery rates after left- versus right-sided colectomies, but there is currently little evidence to inform post-operative care. This study prospectively com...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ans.13823

    authors: Yuan L,O'Grady G,Milne T,Jaung R,Vather R,Bissett IP

    更新日期:2018-04-01 00:00:00

  • Effect of nitric oxide on the hypoglycaemic phase of endotoxaemia.

    abstract:BACKGROUND:Depletion of liver glycogen stores and subsequent hypoglycaemia is one of the unresolved features in endotoxaemia. The aim of this study was to elucidate the effect of L-arginine treatment on the glucose requirement and impending liver damage during the hypoglycaemic period of endotoxaemia. METHODS:Sixty-th...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2006.03763.x

    authors: Engin A,Zemheri M,Bukan N,Memiş L

    更新日期:2006-06-01 00:00:00

  • Progress towards near-zero 90-day mortality: 388 consecutive hepatectomies over a 16-year period.

    abstract:BACKGROUND:Hepatectomy has been the gold standard procedure for curative treatment of benign and malignant hepatobiliary lesions for over a century. The aim of this study is to report on the 16-year experience of a single institution. METHODS:All patients admitted to The Queen Elizabeth Hospital, South Australia, for ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.15304

    authors: Liu J,Reid J,Leopardi L,Edwards S,Trochsler M,Maddern G

    更新日期:2019-09-01 00:00:00

  • Patent Blue V dye anaphylaxis: experience of Australian and New Zealand surgeons.

    abstract:BACKGROUND:Patent Blue V dye (PBVD) can cause severe anaphylaxis. For sentinel node biopsy (SNB) in breast cancer patients, controversy exists as to the utility of PBVD in addition to lymphoscintigraphy. This survey assessed Australian and New Zealand breast surgeons' experience of anaphylaxis with PBVD. METHODS:The s...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2012.06277.x

    authors: Wong A,Spillane A,Breast Surgeons of Australia and New Zealand Incorporated (BreastSurgANZ).

    更新日期:2014-01-01 00:00:00

  • Ten-year evolution of a massive transfusion protocol in a level 1 trauma centre: have outcomes improved?

    abstract:BACKGROUND:We aimed to evaluate the evolution and implementation of the massive transfusion protocol (MTP) in an urban level 1 trauma centre. Most data on this topic comes from trauma centres with high exposure to life-threatening haemorrhage. This study examines the effect of the introduction of an MTP in an Australia...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.15416

    authors: van der Meij JE,Geeraedts LMG Jr,Kamphuis SJM,Kumar N,Greenfield T,Tweeddale G,Rosenfeld D,D'Amours SK

    更新日期:2019-11-01 00:00:00

  • Modified distally based sural adipofascial flap for reconstructing of leg and ankle.

    abstract:BACKGROUND:While free flaps can be used in many cases to cover soft tissue defects in the distal leg and ankle in a single stage, factors such as diabetes and advanced age can interfere with success of vascular anastomoses. METHODS:Twenty-five patients with deep tissue exposure of the distal leg and ankle underwent re...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.12095

    authors: Yang C,Li Y,Geng S,Fu C,Sun J,Bi Z

    更新日期:2013-12-01 00:00:00

  • Factors affecting fluid requirement on the first day after severe burn trauma.

    abstract:BACKGROUND:Parkland formula (PF) is the most often used schema for calculating intravenous resuscitation fluid requirement in burn patients. Some studies have reported that PF underestimates the fluid requirement in 45-63% of patients. The aim of this retrospective study was to analyse factors influencing first-day int...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2007.04221.x

    authors: Csontos C,Foldi V,Fischer T,Bogar L

    更新日期:2007-09-01 00:00:00

  • Pancreatic resection in patients with synchronous extra-pancreatic malignancy: outcomes and complications.

    abstract:BACKGROUND:Patients may present with a resectable pancreatic tumour in the context of a concurrent primary extra-pancreatic malignancy. These patients pose a dilemma regarding their suitability for surgery. We evaluated our experience with such patients who underwent pancreatic resection with curative intent and detail...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.15651

    authors: Mehta S,Tan GI,Nahm CB,Chua TC,Pearson A,Gill AJ,Samra JS,Mittal A

    更新日期:2020-03-01 00:00:00

  • Predicting occult malignancy in nipple discharge.

    abstract:BACKGROUND:This study was a retrospective analysis of patients who underwent minor or major duct surgery for pathological nipple discharge. The results of clinical examination, mammography, ultrasonography and cytodiagnosis of the nipple discharge were studied in order to predict those patients at risk of underlying or...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2010.05270.x

    authors: Alcock C,Layer GT

    更新日期:2010-09-01 00:00:00

  • Gastric antral patch oesophagoplasty for iatrogenic tracheo-oesophageal fistula.

    abstract::Acquired tracheo-oesophageal fistula is a devastating condition, usually occurring as a late manifestation of oesophageal or other thoracic malignancies. In these cases palliation by placement of an oesophageal stent is the preferred option, but management of a large non-malignant fistula is more complex. In many pati...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2007.04036.x

    authors: Talbot ML,Hugh TB,Spratt P

    更新日期:2007-04-01 00:00:00

  • Pilot study of operative fixation of fractured ribs in patients with flail chest.

    abstract:BACKGROUND:Flail chest is a serious injury in trauma with a significant mortality rate, and long-term pain and disability. Traditionally, management has consisted of internal pneumatic splinting, leading to prolonged periods of mechanical ventilation, and its attendant complications. The aim of this study was to assess...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2009.05104.x

    authors: Marasco S,Cooper J,Pick A,Kossmann T

    更新日期:2009-11-01 00:00:00

  • Tumour cell frequency in pleural lavage in cases with stage I epidermoid lung cancer with no visceral pleural involvement.

    abstract:BACKGROUND:The presence of tumour cells in the pleural lavage of lung cancer patients with no malignant pleural effusion is a negative prognosticator. In the present study we aimed to determine the lowest frequency of positive pleural lavage in lung cancer. METHODS:The study included 26 consecutive patients who underw...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2005.03355.x

    authors: Oguzkaya F,Akçali Y,Bilgin M,Haberal A,Akgün H

    更新日期:2005-05-01 00:00:00

  • Morbidity and mortality in cervical spine injuries in the elderly.

    abstract:BACKGROUND:The aim of our study was to identify the demographics and complications in elderly cervical spine injuries and predictive factors for surgery, complications and mortality. We hypothesized younger healthier patients were more likely to undergo surgical intervention. METHODS:A retrospective review of 225 cons...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.14875

    authors: Bokhari AR,Sivakumar B,Sefton A,Lin JL,Smith MM,Gray R,Hartin N

    更新日期:2019-04-01 00:00:00

  • Art of preserving health: studies on the medical supervision of physical exercise.

    abstract::To the ancient Greeks, physical exercise was an essential part of life, especially during adolescence and young adulthood. Long after the end of the Classical Greek era, Roman conquest brought a shift towards martial training, increased professionalism in athletic competition and a weak strand of restorative gymnastic...

    journal_title:ANZ journal of surgery

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1445-2197.2009.05149.x

    authors: Thurston AJ

    更新日期:2009-12-01 00:00:00

  • Prevalence of Helicobacter pylori in gastric cancer in a South-East Asian population by 14C-urea breath test.

    abstract:BACKGROUND:Helicobacter pylori is believed to play an important role in the aetiology of gastric cancer. There is a great variability in seropositivity and histological frequency of H. pylori in gastric cancer. The present prospective study investigates the prevalence of H. pylori infection in gastric cancer patients u...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1046/j.1445-2197.2001.02208.x

    authors: Chung AY,Chow PK,Yu WK,Ho JM,Chan HS,Wong WK,Soo KC

    更新日期:2001-10-01 00:00:00

  • Laparoscopic revision of gastric band surgery.

    abstract:AIM:To identify the outcome of laparoscopic revision of gastric band surgery with respect to percentage of excess weight lost (%EWL). METHODS:Analysis of a prospective database was then performed and %EWL was plotted with respect to time from initial procedure and also time from revision procedure. RESULTS:All revisi...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2009.05088.x

    authors: Bardsley S,Hopkins G

    更新日期:2010-05-01 00:00:00

  • Renal artery embolization prior to nephrectomy for locally advanced renal cell carcinoma.

    abstract:BACKGROUND:To assess the outcomes of patients undergoing percutaneous renal artery embolization (PRAE) prior to radical nephrectomy. METHODS:We performed retrospective chart review of patients undergoing PRAE in Auckland Public Hospital from January 2004 to December 2011. PRAE was performed under epidural anaesthesia ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.12545

    authors: Zargar H,Addison B,McCall J,Bartlett A,Buckley B,Rice M

    更新日期:2014-07-01 00:00:00

  • Endoscopic cyst-gastrostomy for pancreatic pseudocysts: refining the indications.

    abstract:BACKGROUND:Pseudocysts are a common consequence of acute pancreatitis and require intervention if symptomatic. Endoscopic management is emerging as a safe and effective alternative to surgery, although its use is not yet widespread. METHODS:We describe our experience of 10 consecutive unselected patients who underwent...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.12648

    authors: Due SL,Wilson TG,Chung A,Chen JW

    更新日期:2016-05-01 00:00:00

  • Creating change: building the capacity of the medical workforce in Aboriginal health.

    abstract:BACKGROUND:This paper provides an overview of the long-term strategies that have been in place at the University of Western Australia, which aim to build the capacity and preparedness of the health-care workforce in Aboriginal health. In 1996, the Centre for Aboriginal Medical and Dental Health was established within t...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.12031

    authors: Paul D

    更新日期:2013-01-01 00:00:00

  • Paintings from the Cushing/Whitney Library of Yale University: the Eleventh Kenneth Fitzpatrick Russell Memorial Lecture - 2012.

    abstract::In the early years of the introduction of Christianity into China, one American medical missionary distinguished himself by his kindness and generosity towards the Chinese people, and also by his surgical prowess. Peter Parker (1804-1888) was a graduate from the Yale University Medical School and was also an ordained ...

    journal_title:ANZ journal of surgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1111/ans.12402

    authors: Low G

    更新日期:2013-12-01 00:00:00

  • Facial transplantation as an option in reconstructive surgery: no mountains too high?

    abstract:BACKGROUND:Human facial allotransplantation (FA) is a testament to the impressive progress, which was and is still happening in the field of transplantation medicine and reconstructive surgery. Like every pioneering treatment option, FA faces both the clinicians' and public opinion with a huge amount of medical and psy...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1111/j.1445-2197.2009.05140.x

    authors: Błogowski W

    更新日期:2009-12-01 00:00:00

  • Surgical wisdom and Genghis Khan's Pax Mongolica.

    abstract:BACKGROUND:The unrivalled conquests of Genghis Khan (CE c.1162-1227) led to the establishment of the Greater Mongolian Empire. By 1279, the Mongol dynasty controlled a vast Empire which, for the first time in history, unified Europe and China via the famous Silk Road. The ensuing century of peace and stability is refer...

    journal_title:ANZ journal of surgery

    pub_type: 历史文章,杂志文章

    doi:10.1111/ans.13813

    authors: Köstenbauer J

    更新日期:2017-03-01 00:00:00

  • Robotic complete mesocolic excision and central vascular ligation for right-sided colon cancer: short-term outcomes from a case series.

    abstract:BACKGROUND:Despite conflicting data regarding oncological outcomes, studies demonstrate that complete mesocolic excision (CME) and central vascular ligation (CVL) for right-sided colon cancer removes significantly more tissue and yields higher lymph node counts when compared to conventional resection. This study aims t...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.16224

    authors: Larach JT,Rajkomar AKS,Narasimhan V,Kong J,Smart PJ,Heriot AG,Warrier SK

    更新日期:2020-08-11 00:00:00

  • Thirteen-year experience with hand-assisted laparoscopic surgery in colorectal patients.

    abstract:BACKGROUND:We report outcomes on 324 consecutive cases of hand-assisted laparoscopic surgery (HALS) in colorectal patients over 13 years performed by a single surgeon. METHODS:A prospectively maintained database was used to identify all patients undergoing HALS colorectal procedures for benign or malignant indications...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.15578

    authors: Siddiqui J,Young CJ

    更新日期:2020-01-01 00:00:00

  • A survey of general surgery clerkships in Australian and New Zealand medical schools.

    abstract:BACKGROUND:Surgical clerkships facilitate development of knowledge and competency, but their structure and content vary. Establishment of new medical schools and raising student numbers are new challenges to the provision of standardized surgical teaching across Australasian medical schools. A survey was conducted to i...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2010.05524.x

    authors: Yu TC,Wheeler BR,Hill AG

    更新日期:2010-12-01 00:00:00

  • Weasels, keys and Thersites.

    abstract::It was the achievement of Andreas Vesalius (1514-1564) to redefine the understanding of human anatomy; and that of Homer was to write the first historical novel. This paper offers a link between the works of these two venturers, by way of an examination of the clinical anatomy of the clavicle. ...

    journal_title:ANZ journal of surgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1111/j.1445-2197.2011.05711.x

    authors: Beasley AW

    更新日期:2011-12-01 00:00:00

  • Fissure-last video-assisted thoracoscopic lobectomy for 'non-upper' lobes.

    abstract:BACKGROUND:Surgical approach into the fissural parenchyma may be an important and modifiable factor for the prevention of air leak after anatomical lung resections. Fissureless fissure-last technique has been described as useful technique to reduce air leak, yet in video-assisted thoracoscopic surgery (VATS) data are l...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.13884

    authors: Stamenovic D,Bostanci K,Messerschmidt A,Tillmann J,Kostic M,Schneider T

    更新日期:2017-12-01 00:00:00

  • Risk factors for multidrug-resistant Gram-negative infection in burn patients.

    abstract:BACKGROUND:Infection with multidrug-resistant (MDR) Gram-negative organisms leads to poorer outcomes in the critically ill burn patient. The aim of this study was to identify the risk factors for MDR Gram-negative pathogen infection in critically ill burn patients admitted to a major tertiary referral intensive care un...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.14144

    authors: Vickers ML,Dulhunty JM,Ballard E,Chapman P,Muller M,Roberts JA,Cotta MO

    更新日期:2018-05-01 00:00:00