Clinicopathological prognostic factors and impact of surgical treatment of mass-forming intrahepatic cholangiocarcinoma.


:The clinicopathological characteristics relevant to prognosis after surgical treatment of intrahepatic cholangiocarcinoma (ICC) remain unclear. In this study, the clinicopathological features of 19 patients with mass-forming ICC, the most common form of the disease, were reviewed to analyze prognostic determinants. Two or more segmentectomies of the liver with systematic lymphadenectomy were performed in 18 patients. Resection of the extrahepatic bile duct was performed in 14 patients, and reconstruction of the portal vein was accomplished in 5 patients. Stage IVA or IVB tumors were seen in 13 patients, and lymph node (LN) metastasis was present in 14 patients. The estimated 5-year survival rate after surgery for mass-forming ICC was 28%, with median survival time of 18 months. In univariate analysis, five variables were determined to be significantly correlated with poor survival of patients with mass-forming ICC after surgery. These variables include mass-forming ICC with periductal infiltration, perineural invasion, portal vein invasion, presence of intrahepatic metastasis, and two or more LN metastases. Survival rates of 5 patients without LN metastasis and 6 patients with a single LN metastasis were 80% and 33% at 5 years, respectively, while 8 patients with two or more LN metastasis failed to survive beyond 2 years. Multivariate analysis revealed the presence of intrahepatic metastasis to be an independent prognostic factor of poor survival. Hepatectomy with resection of the extrahepatic bile duct and systematic lymphadenectomy yields a good chance for prolonged survival for patients with mass-forming ICC when the lesion is singular and LN metastasis is limited to a regional LN. Because the presence of intrahepatic metastasis was closely related to a poor prognosis in patients with mass-forming ICC, efficacious chemotherapy would be needed to control development of the lesion.


World J Surg


World journal of surgery


Suzuki S,Sakaguchi T,Yokoi Y,Okamoto K,Kurachi K,Tsuchiya Y,Okumura T,Konno H,Baba S,Nakamura S





Has Abstract


2002-06-01 00:00:00












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    abstract:BACKGROUND:Loop ileostomy reduces the rates of morbidity due to colorectal anastomotic dehiscence. For its part, ileostomy closure is associated with low mortality (0-4%) but substantial morbidity (11-37%). Incisional surgical site infection (SSI) is one of the most frequent complications (2-40%). METHODS:A single-cen...

    journal_title:World journal of surgery

    pub_type: 杂志文章,随机对照试验


    authors: Serracant A,Serra-Aracil X,Mora-López L,Pallisera-Lloveras A,Serra-Pla S,Zárate-Pinedo A,Navarro-Soto S

    更新日期:2019-07-01 00:00:00

  • Analysis of 203 patients with penetrating neck injuries.

    abstract:BACKGROUND:Selective nonoperative management (SNOM) of penetrating neck injuries (PNI) has steadily gained favor, but indications for surgery and adjunctive diagnostic studies remain debated. The purpose of the present study is to validate a protocol of SNOM of PNI based on physical examination, which further dictates ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Thoma M,Navsaria PH,Edu S,Nicol AJ

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    abstract::Adenocarcinomas of the esophagogastric junction (AEG) are now recognized as a separate tumor entity with increasing incidence. The aim of the present study was to evaluate whether positron emission tomography (PET) using the glucose analog F-18-fluorodeoxyglucose (FDG) can be used for metabolic characterization of thi...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Ott K,Weber WA,Fink U,Helmberger H,Becker K,Stein HJ,Müller J,Schwaiger M,Siewert JR

    更新日期:2003-09-01 00:00:00

  • Evolving Management of Zenker's Diverticulum in the Endoscopic Era: A North American Experience.

    abstract:BACKGROUND:Open surgical cricopharyngeal myotomy(CM) is considered standard of care for Zenker's diverticulum(ZD). Trans-oral CM has been described using a rigid stapling device for two decades; however, this remains problematic for severely kyphotic patients. This problem can be overcome with flexible endoscopy utiliz...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Jones D,Aloraini A,Gowing S,Cools-Lartigue J,Leimanis M,Tabah R,Ferri L

    更新日期:2016-06-01 00:00:00

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    abstract:BACKGROUND:Medullary thyroid carcinoma (MTC) originates from calcitonin-producing cells of the thyroid. In 2009, we published our first report on the biological characteristics and prognosis of 118 MTC patients. Herein, we enrolled a larger number of patients with longer follow-up periods to further study the biologica...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Ito Y,Miyauchi A,Kihara M,Higashiiyama T,Fukushima M,Miya A

    更新日期:2018-12-01 00:00:00

  • Comprehensive Complication Index or Clavien-Dindo Classification: Which is Better for Evaluating the Severity of Postoperative Complications Following Pancreatectomy?

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    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Kim SH,Hwang HK,Lee WJ,Kang CM

    更新日期:2021-03-01 00:00:00

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    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Mandal AK,Sanusi M

    更新日期:2001-09-01 00:00:00

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    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


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    更新日期:2007-05-01 00:00:00

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    journal_title:World journal of surgery

    pub_type: 杂志文章


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    更新日期:2018-07-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


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    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Gravelle IH,Lyons K

    更新日期:1989-11-01 00:00:00

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    journal_title:World journal of surgery

    pub_type: 杂志文章


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    更新日期:2021-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Saeed A,Khan AR,Lee V,Aslam A,Brain J,Williams MP,Brennan L,Campbell R,Samuel M

    更新日期:2009-03-01 00:00:00

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    journal_title:World journal of surgery

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:1996-06-01 00:00:00

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    authors: Park JY,Ryu KW,Reim D,Eom BW,Yoon HM,Rho JY,Choi IJ,Kim YW

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    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Lam CR

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    pub_type: 杂志文章


    authors: Zhu ZJ,Chen LQ,Duranceau A

    更新日期:2008-03-01 00:00:00

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    pub_type: 杂志文章,meta分析,评审


    authors: Bobkiewicz A,Francuzik W,Krokowicz L,Studniarek A,Ledwosiński W,Paszkowski J,Drews M,Banasiewicz T

    更新日期:2016-12-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Tovey FI

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    pub_type: 杂志文章


    authors: Chapuis Y,Pitre J,Conti F,Abboud B,Pras-Jude N,Luton JP

    更新日期:1996-09-01 00:00:00

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    journal_title:World journal of surgery

    pub_type: 杂志文章


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    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Beger HG,Büchler M

    更新日期:1990-01-01 00:00:00

  • Self-Inflicted Abdominal Stab Wounds Have a Higher Rate of Non-therapeutic Laparotomy/Laparoscopy and a Lower Risk of Injury.

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    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Bugaev N,McKay K,Breeze JL,Arabian SS,Rabinovici R

    更新日期:2017-11-01 00:00:00

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    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Meier RP,de Saussure WO,Orci LA,Gutzwiller EM,Morel P,Ris F,Schwenter F

    更新日期:2014-12-01 00:00:00

  • Adhesion-related complications are common, but rarely discussed in preoperative consent: a multicenter study.

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    journal_title:World journal of surgery

    pub_type: 杂志文章,多中心研究


    authors: Rajab TK,Wallwiener M,Talukdar S,Kraemer B

    更新日期:2009-04-01 00:00:00

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    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Alyami M,Passot G,Voiglio E,Lundberg PW,Valette PJ,Muller A,Caillot JL

    更新日期:2015-12-01 00:00:00

  • The Use of Three-Dimensional Printing Model in the Training of Choledochoscopy Techniques.

    abstract:AIM:To evaluate the application value of a three-dimensional (3D) printing model in the training of choledochoscopy techniques. MATERIALS AND METHODS:Imaging data from two patients with biliary dilatation were used to produce two 3D reconstruction models which were subsequently constructed into 3D printing models (No....

    journal_title:World journal of surgery

    pub_type: 杂志文章,随机对照试验


    authors: Li A,Tang R,Rong Z,Zeng J,Xiang C,Yu L,Zhao W,Dong J

    更新日期:2018-12-01 00:00:00