Glycoprotein IIb/IIIa receptor inhibitor-thrombolytic combination therapy for acute myocardial infarction.

Abstract:

:Over the past two decades, we have witnessed a large decrease in the death and complication rate of patients experiencing acute myocardial infarction (MI), due to our ability to restore blood flow to infarct-related arteries. Therapies include strategies to inhibit platelet function and induce fibrinolysis, and mechanical reperfusion with percutaneous intervention. Despite decreases in morbidity and mortality with thrombolytic therapy, reperfusion rates remain less than optimal. With standard fibrinolytic therapy in combination with aspirin, it is thought that thrombolytic-induced platelet activation may be an important reason for failure to induce perfusion, or maintain reperfusion in the infarct-related artery. In the past 10 years we have moved from platelet inhibition with aspirin to newer, more potent platelet inhibitors such as glycoprotein (GP) IIb/IIIa antagonists. Recent trials have evaluated the efficacy and safety of combining thrombolytic drugs with GP IIb/IIIa receptor antagonists. Future trends may use combination therapy as a part of a mechanical strategy, using these medications to induce early reperfusion as the patient is prepared for percutaneous intervention. This review summarizes recently published trials using combination thrombolytic and GP IIb/IIIa receptor inhibitor therapy in the treatment of acute MI.

journal_name

Curr Cardiol Rep

authors

Maranian AM,Steinhubl SR

doi

10.1007/s11886-002-0067-8

keywords:

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

313-9

issue

4

eissn

1523-3782

issn

1534-3170

journal_volume

4

pub_type

杂志文章,评审
  • Radial Artery Versus Saphenous Vein Grafts in Coronary Artery Bypass Surgery: a Literature Review.

    abstract:PURPOSE OF REVIEW:Coronary artery bypass grafting is a preferred strategy for complete coronary revascularization in patients who have multi-vessel coronary artery disease, left ventricular dysfunction, and/or diabetes. Both arterial (internal thoracic artery/radial artery) and venous grafts are utilized to bypass the ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1112-1

    authors: Virk HUH,Lakhter V,Ahmed M,O' Murchu B,Chatterjee S

    更新日期:2019-03-22 00:00:00

  • Targeted Nuclear Imaging Probes for Cardiac Amyloidosis.

    abstract:PURPOSE OF REVIEW:The aim of the present manuscript is to review the latest advancements of radionuclide molecular imaging in the diagnosis and prognosis of individuals with cardiac amyloidosis. RECENT FINDINGS:99mTechnetium labeled bone tracer scintigraphy had been known to image cardiac amyloidosis, since the 1980s;...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-017-0868-4

    authors: Bravo PE,Dorbala S

    更新日期:2017-07-01 00:00:00

  • Imaging, Health Record, and Artificial Intelligence: Hype or Hope?

    abstract:PURPOSE OF REVIEW:The review is focused on "digital health", which means advanced analytics based on multi-modal data. The "Health Care Internet of Things", which uses sensors, apps, and remote monitoring could provide continuous clinical information in the cloud that enables clinicians to access the information they n...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-0990-y

    authors: Mazzanti M,Shirka E,Gjergo H,Hasimi E

    更新日期:2018-05-10 00:00:00

  • Multimodality imaging for assessment of myocardial viability: nuclear, echocardiography, MR, and CT.

    abstract::The assessment of myocardial viability may be an important component of the evaluation of patients with coronary artery disease and left ventricular dysfunction. The primary goal of viability assessment in such patients is to guide therapeutic decisions by determining which patients would most likely benefit from reva...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-011-0242-x

    authors: Arrighi JA,Dilsizian V

    更新日期:2012-04-01 00:00:00

  • Should Angiotensin-Converting Enzyme Inhibitors ever Be Used for the Management of Hypertension?

    abstract:PURPOSE OF REVIEW:Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are commonly used anti-hypertensive medications in a number of clinical settings. They are often used interchangeably, but we pose the provocative question as to whether they should be. We review the literature to evaluate for ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01352-8

    authors: Turner JM,Kodali R

    更新日期:2020-07-09 00:00:00

  • Clinical Application of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention for Stable Coronary Artery Disease.

    abstract::Revascularization in stable ischemic heart disease (SIHD) is indicated in patients on optimal medical therapy with angina and/or demonstrable ischemia and a significant stenosis in one or more epicardial coronary arteries. Angiography alone, however, cannot accurately determine the hemodynamic significance of coronary...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-016-0711-3

    authors: Parikh V,Agnihotri K,Kadavath S,Patel NJ,Abbott JD

    更新日期:2016-04-01 00:00:00

  • Dosing considerations and monitoring of low molecular weight heparins and glycoprotein IIb/IIIa antagonists in patients with renal insufficiency.

    abstract::Glycoprotein IIb/IIIa inhibitors and low molecular heparins are important new components of the medical treatment for acute coronary syndromes (ACS). Renal insufficiency is a common comorbid condition and high-risk marker for ACS. The safety and efficacy of these treatments in ACS are dependent on the pharmacokinetics...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-003-0067-3

    authors: Rammohan C,Fintel D

    更新日期:2003-07-01 00:00:00

  • What is the role of aldosterone excess in resistant hypertension and how should it be investigated and treated?

    abstract::Resistant hypertension has evolved as an important global health care problem. Primary aldosteronism is one of several potentially reversible causes of resistant hypertension. Primary aldosteronism can be effectively treated, when recognized, with a mineralocorticoid receptor antagonist, such as spironolactone and epl...

    journal_title:Current cardiology reports

    pub_type: 杂志文章

    doi:10.1007/s11886-011-0224-z

    authors: Sica DA

    更新日期:2011-12-01 00:00:00

  • Management of patients with stroke and a patent foramen ovale.

    abstract::Observational studies have established a strong association between the presence of patent foramen ovale (PFO) and increased risk of ischemic stroke. The mechanism involved is presumed to be a paradoxical embolism from a venous thrombus that travels via the PFO to the systemic circulation. The best treatment modality ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-004-0013-z

    authors: Rodriguez CJ,Homma S

    更新日期:2004-03-01 00:00:00

  • Variant Angina and Aborted Sudden Cardiac Death.

    abstract:PURPOSE OF REVIEW:Variant angina, which is characterized by recurrent chest pain and transient ECG changes along with angiographic evidence of coronary artery spasm, generally has a favorable prognosis. However, episodes of ischemia caused by vasospasm may lead to potentially life-threatening ventricular arrhythmias an...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-0963-1

    authors: Kundu A,Vaze A,Sardar P,Nagy A,Aronow WS,Botkin NF

    更新日期:2018-03-08 00:00:00

  • Optimal Dietary Strategies for Prevention of Atherosclerotic Cardiovascular Disease in Diabetes: Evidence and Recommendations.

    abstract:PURPOSE OF REVIEW:This review presents the current available evidence of the effects of several dietary patterns on atherosclerotic cardiovascular disease (ASCVD) risk in patients with type 2 diabetes (T2D). RECENT FINDINGS:Evidence demonstrates improvements in cardiovascular risk factors with some dietary patterns in...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1232-7

    authors: Liday C,Kirkpatrick C

    更新日期:2019-10-17 00:00:00

  • Impact of Gut Microbiota on Obesity, Diabetes, and Cardiovascular Disease Risk.

    abstract::Gut microbiota has been recently established to have a contributory role in the development of cardiometabolic disorders, such as atherosclerosis, obesity, and type 2 diabetes. Growing interest has focused on the modulation of gut microbiota as a therapeutic strategy in cardiovascular diseases and metabolic disorders....

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0671-z

    authors: Miele L,Giorgio V,Alberelli MA,De Candia E,Gasbarrini A,Grieco A

    更新日期:2015-12-01 00:00:00

  • Update in the Management of Acute Coronary Syndrome Patients with Cardiogenic Shock.

    abstract:PURPOSE OF REVIEW:We provide a concise update on the contemporary management of cardiogenic shock in the setting of acute coronary syndrome (ACS). Early shock recognition, optimal selection and initiation of mechanical circulatory support (MCS), early coronary revascularization, and a team-based, protocol-driven approa...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1102-3

    authors: Bagai J,Brilakis ES

    更新日期:2019-03-04 00:00:00

  • What niche will newer class III antiarrhythmic drugs occupy?

    abstract::The decline in the use of sodium channel blockers has led to an expanding use of b-blockers and complex class III agents such as sotalol and amiodarone for controlling cardiac arrhythmias. Success with these agents in the context of their side effects has spurred the development of compounds with simpler ion channel-b...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-001-0086-x

    authors: Singh BN,Sarma JS

    更新日期:2001-07-01 00:00:00

  • A full house: complications from an uncorrected patent ductus arteriosus.

    abstract::True aneurysms of the pulmonary artery are rare, and are most often due to pulmonary hypertension arising from congenital heart defects. We report the case of a 40-year-old man with an uncorrected patent ductus arteriosus who presented with pulmonary infarction and pneumonia, and subsequently died of cardiac arrest. A...

    journal_title:Current cardiology reports

    pub_type: 杂志文章

    doi:10.1007/s11886-005-0054-y

    authors: Khush KK,Randhawa R,Israel E

    更新日期:2005-07-01 00:00:00

  • Healthcare Cost Implications of Utilizing a Dietary Intervention to Lower LDL Cholesterol: Proof of Concept Actuarial Analysis and Recommendations.

    abstract:PURPOSE OF REVIEW:To determine if subsidizing the cost of a food-based intervention for managing hyperlipidemia could be cost-effective under commercial insurance and/or Medicare coverage scenarios. RECENT FINDINGS:A large number of patients eligible for pharmaceutical treatment of hyperlipidemia either cannot or will...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01397-9

    authors: Dong I,Klodas E

    更新日期:2020-09-10 00:00:00

  • Transcatheter aortic valve replacement: an update.

    abstract::Aortic stenosis affects many people worldwide with a significant impact on morbidity and mortality with uncorrected, symptomatic aortic valve stenosis carrying mortality of 50% at one year. Degenerative calcific pathology, the most common cause of aortic stenosis, increases in prevalence with age; estimated prevalence...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-013-0367-1

    authors: Halim SA,Kiefer TL,Hughes GC,Hurwitz LM,Harrison JK

    更新日期:2013-06-01 00:00:00

  • Amiodarone: a multifaceted antiarrhythmic drug.

    abstract::Synthesized as an antianginal compound 40 years ago, amiodarone has emerged as a uniquely effective antiarrhythmic compound in recent years. It has numerous properties, the most prominent being the ability to lengthen repolarization in the atria and ventricles associated with bradycardia without the significant potent...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-006-0074-2

    authors: Singh BN

    更新日期:2006-09-01 00:00:00

  • Atrial fibrillation ablation in octogenarians: where do we stand?

    abstract::The prevalence of atrial fibrillation increases significantly with age, affecting nearly 10 % of adults greater than 80 years of age. Complications from atrial fibrillation, including stroke, also increase with age. Medical therapy includes anticoagulation, ventricular rate control, and if symptoms persist, maintenanc...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-013-0406-y

    authors: Stepanyan G,Gerstenfeld EP

    更新日期:2013-10-01 00:00:00

  • Redefining the role of cardiovascular imaging in patients with pulmonary arterial hypertension.

    abstract::While pulmonary arterial hypertension is a disease primarily affecting the pulmonary vasculature, the right ventricle plays an integral part in the disease process. Although widely used, two-dimensional echocardiography is limited in visualizing the right ventricle and, therefore, assessment of its structure and funct...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-012-0253-2

    authors: Freed BH,Patel AR,Lang RM

    更新日期:2012-06-01 00:00:00

  • PET Imaging of the Human Nicotinic Cholinergic Pathway in Atherosclerosis.

    abstract::During the past years, non-neuronal vascular nicotinic acetylcholine receptors (nAChRs) increasingly have gained interest in cardiovascular research, as they are known to mediate the deleterious effects of nicotine and nitrosamines, components of tobacco smoke, on the vasculature. Because smoking is a major risk facto...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0614-8

    authors: Bauwens M,Mottaghy FM,Bucerius J

    更新日期:2015-08-01 00:00:00

  • Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Treatment of Unprotected Left Main Stenosis.

    abstract:PURPOSE OF REVIEW:This article reviews the latest data on unprotected left main (ULM) percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) surgery, with a focus on the NOBLE and EXCEL trials. RECENT FINDINGS:In EXCEL trial, the primary endpoint at 3 years was 15.4% in the PCI group and 1...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1113-0

    authors: Taha Y,Patel RAG,Bagai J,Sachdeva R,Kumar G,Prasad A,Nathan S,Paul TK

    更新日期:2019-03-18 00:00:00

  • Imaging Approaches for Coronary Artery Anomalies: Purpose and Techniques.

    abstract:PURPOSE OF REVIEW:Comprehensive discussion of alternative techniques in imaging coronary artery anomalies (CAAs) in different diagnostic scenarios. RECENT FINDINGS:At primary screening, intramural course essentially correlates with stenosis and clinical repercussion in some types of CAAs. Potential clinical aims in im...

    journal_title:Current cardiology reports

    pub_type: 杂志文章

    doi:10.1007/s11886-019-1188-7

    authors: Angelini P

    更新日期:2019-07-29 00:00:00

  • Sex-Related Differences in Dilated Cardiomyopathy with a Focus on Cardiac Dysfunction in Oncology.

    abstract:PURPOSE OF REVIEW:The aim of this report is to describe the main aspects of sex-related differences in non-ischemic dilated cardiomyopathies (DCM), focusing on chemotherapy-induced heart failure (HF) and investigating the possible therapeutic implications and clinical management applications in the era of personalized ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01377-z

    authors: D'Amario D,Camilli M,Migliaro S,Canonico F,Galli M,Arcudi A,Montone RA,Borovac JA,Crea F,Savarese G

    更新日期:2020-08-08 00:00:00

  • State of the Art of Combined Heart-Lung Transplantation for Advanced Cardiac and Pulmonary Dysfunction.

    abstract::Over the last several decades, significant advances and improvements in care of transplant patients have resulted in markedly improved outcomes. A number of options are available for patients with advanced cardiopulmonary dysfunction requiring transplantation. There is a debate about when isolated heart or isolated lu...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-016-0713-1

    authors: Idrees JJ,Pettersson GB

    更新日期:2016-04-01 00:00:00

  • Transradial versus transfemoral approach for percutaneous coronary procedures.

    abstract::Selective coronary angiography was originally performed through open brachial arteriotomy. Thereafter, the percutaneous Seldinger technique and the use of preformed Judkins-type catheters popularized the femoral approach. More recently, after the first report of successful coronary angiography by the transradial appro...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-009-0054-4

    authors: Franchi E,Marino P,Biondi-Zoccai GG,De Luca G,Vassanelli C,Agostoni P

    更新日期:2009-09-01 00:00:00

  • Correction to: Review of Transthyretin Silencers, Stabilizers, and Fibril Removal Agents in the Treatment of Transthyretin Cardiac Amyloid.

    abstract::On page 2 of the original publication, in the section on TTR Silencers dosing of patisiran in the APOLLO study was stated as being given every 3 months; this is inaccurate as patisiran was dosed every 3 weeks in the APOLLO study. ...

    journal_title:Current cardiology reports

    pub_type: 已发布勘误

    doi:10.1007/s11886-020-01426-7

    authors: Hough A,Wearden J,de Almeida K,Kaiser S

    更新日期:2020-09-28 00:00:00

  • Rationale and Current Evidence for Testing Iron Chelators for Treating Stroke.

    abstract:PURPOSE OF REVIEW:To discuss the mechanisms of iron regulation in the brain and the pathophysiological role of deregulation of iron homeostasis following a stroke, and to review existing evidence supporting the potential role of iron chelators in the treatment of ischemic and hemorrhagic stroke. RECENT FINDINGS:In rec...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1106-z

    authors: Hanafy KA,Gomes JA,Selim M

    更新日期:2019-03-04 00:00:00

  • Aortic valve disease: current recommendations.

    abstract::Aortic stenosis is a common valvular abnormality. Surgical valve replacement is the standard of care for symptomatic patients with severe aortic stenosis and is appropriate for certain asymptomatic patients. Statin therapy may slow progression of the disease. Contrary to conventional wisdom, vasodilator therapy may in...

    journal_title:Current cardiology reports

    pub_type: 杂志文章

    doi:10.1007/s11886-004-0004-0

    authors: Botkin NF,Aurigemma GP

    更新日期:2004-03-01 00:00:00

  • Advances in PET-Based Cardiac Amyloid Radiotracers.

    abstract::The gold standard for diagnosis of cardiac amyloidosis (CA) is endomyocardial biopsy showing Congo red staining followed by mass spectroscopy, but the diagnosis can also be made with high certainty by demonstration of typical cardiac imaging features along with amyloid on biopsy of another involved organ. The use of c...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01284-3

    authors: Gallegos C,Miller EJ

    更新日期:2020-05-19 00:00:00