[Clinico-hemodynamic study and treatment of 44 patients with primary pulmonary hypertension].

Abstract:

BACKGROUND:Primary pulmonary hypertension is a poorly understood disease with a difficult treatment. PATIENTS AND METHOD:Retrospective study of a series of 44 patients suffering from pulmonary hypertension who were studied in our center between 1992 and 2000. RESULTS:At diagnosis, 6 (13%) patients were classified as having NYHA functional class I, 11 (25%) had class II, 25 (57%) had class III, and 2 had class IV. Mean pulmonary artery systolic pressure by echo-doppler was 92 (range: 43-154) mmHg. Basal right catheterization showed a mean (SD) pulmonary artery pressure of 58 (18) mmHg, total basal pulmonary resistances of 1679 (1,071) din/cm2 and cardiac index of 2.2 (1) 1/minute/m2. Five patients improved with anticoagulation and calcium channel blockers therapy. Since 1998, 11 patients had been treated with continuous endovenous epoprostenol, yet only 3 (27%) had significant clinical improvement. Survival at 5 years after diagnosis was 56%. At the end of study, 7 (70%) out of 10 patients who underwent pulmonary transplantation were alive (mean: 34, range: 3-62 months). CONCLUSIONS:Pulmonary hypertension is a disease with a poor prognosis. However, treatment with prostaglandins and pulmonary transplantation may lead to encouraging results.

journal_name

Med Clin (Barc)

journal_title

Medicina clinica

authors

Roman A,Rodés-Cabau J,Lara B,Bravo C,Monforte V,Pallissa E,Domingo E,Morell F

doi

10.1016/s0025-7753(02)72524-4

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

761-6

issue

20

eissn

0025-7753

issn

1578-8989

pii

S0025-7753(02)72524-4

journal_volume

118

pub_type

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