Importance of lymph node metastases in follicular thyroid cancer.


:There are many concepts of risk and prognostic factor analysis for differentiated thyroid cancer. The prognostic role of lymph node metastases in follicular thyroid cancer (FTC), however, is still controversial. We performed a retrospective trial in 186 patients with FTC (124 women, 62 men; mean follow-up 5.5 years) questioning whether lymph node metastases and radical thyroid surgery with neck dissection contribute to the prognosis of FTC. Univariate analysis demonstrated that lymph node metastasesp <0.005), tumor size (p <0.005), tumor stage (p <0.005), distant metastases p = 0.0063), and gender (p = 0.003) are significant prognostic factors for recurrence (Kaplan-Meier). Tumor size (p = 0.004), lymph node metastases p = 0.0478), and distant metastases p = 0.0064) influenced mortality. Age and extent of surgery were not significant for recurrence nor was gender for mortality. Multivariate analysis (Cox regression test) characterized tumor size (p <0.005) and lymph node metastases p = 0.004) as prognostic factors for recurrence of FTC. No significant difference was detected between patients being treated by thyroidectomy when compared to patients treated by thyroidectomy plus neck dissection in relation to recurrence. Our data demonstrate lymph node metastases to be a significant prognostic factor for recurrence of FTC and the patient's survival. We advocate thyroidectomy plus central lymph node dissection as the basic surgical strategy. For T3 and T4 tumors, unilateral modified neck dissection is an all but optional procedure. Whether radical surgery with thyroidectomy plus neck dissection has an impact on survival remains questionable.


World J Surg


World journal of surgery


Witte J,Goretzki PE,Dieken J,Simon D,Röher HD





Has Abstract


2002-08-01 00:00:00












  • Incidence of venous thromboembolism and its pharmacological prophylaxis in Asian general surgery patients: a systematic review.

    abstract:BACKGROUND:Venous thromboembolism (VTE) is a condition that has always been perceived to be rare in Asia. The aim of this systematic review was to gather the current available evidence on the incidence of VTE in this population. A secondary aim was to assess the efficacy of pharmacological prophylaxis, and hence determ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Yeo DX,Junnarkar S,Balasubramaniam S,Tan YP,Low JK,Woon W,Pang TC

    更新日期:2015-01-01 00:00:00

  • Taeniectomy Versus Transverse Coloplasty as Neorectum After Low Rectal Resection.

    abstract:PURPOSE:Restorative surgery for rectal cancer is usually criticized by its functional outcomes. The aim of this study is to assess the efficacy "taeniectomy" pouch in comparison with transverse coloplasty pouch. STUDY DESIGN:This was a prospective controlled study. Most patients who were candidate for low rectal resec...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Farag A,Mashhour AN,Elbarmelgi MY

    更新日期:2019-04-01 00:00:00

  • Improved Outcomes of Laparoscopic Liver Resection for Hepatocellular Carcinoma Located in Posterosuperior Segments of the Liver.

    abstract:BACKGROUND:LLR is widely adapted for HCC, while LLR in PS segments is still challenging. With recent improvement of techniques and accumulation of experiences, LLR in PS segments is feasible, but studies investigating the result after the modifications are lacking. METHODS:In this single-center, retrospective study, 1...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Kwon Y,Cho JY,Han HS,Yoon YS,Lee HW,Lee JS,Lee B,Kim M

    更新日期:2021-01-13 00:00:00

  • Current concepts in inguinal hernia in infants and children.

    abstract::Trends are changing in the management of infants and children with indirect inguinal hernias. Advances in neonatal intensive care have resulted in the survival of many small premature infants who have a high incidence of inguinal hernia. The rate of incarceration, strangulation, and gonadal infarction in these babies ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Grosfeld JL

    更新日期:1989-09-01 00:00:00

  • Clinical Relevance of Reductive Hepatectomy for Barcelona Clinic Liver Cancer Stages B and C Advanced Hepatocellular Carcinoma: A Single-Center Experience of 102 Patients.

    abstract:BACKGROUND:This study aimed to evaluate the clinical relevance of hepatectomy for Barcelona Clinic Liver Cancer (BCLC) stages B and C advanced hepatocellular carcinoma (HCC). METHODS:A total of 314 patients (149 and 165 BCLC stages B and C, respectively) who underwent hepatectomy were included. Complete hepatectomy (w...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Komatsu S,Kido M,Tanaka M,Kuramitsu K,Tsugawa D,Awazu M,Gon H,Toyama H,Ueno K,Fukumoto T

    更新日期:2019-10-01 00:00:00

  • The Reliability of the Pre-hospital Physical Examination of the Pelvis: A Retrospective, Multicenter Study.

    abstract:INTRODUCTION:This study assesses the incidence of missed pelvic injuries in the pre-hospital setting. METHODS:All blunt trauma patients (ISS ≥ 9) with pre-hospital suspicion of and/or radiologically proven pelvic fracture documented in the TraumaRegister DGU® (TR-DGU) of the German Trauma Society DGU (2002-2011) were ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,多中心研究


    authors: Lustenberger T,Walcher F,Lefering R,Schweigkofler U,Wyen H,Marzi I,Wutzler S,TraumaRegister DGU.

    更新日期:2016-12-01 00:00:00

  • Risk factors and management of local recurrence following breast conservation surgery.

    abstract::Although a number of histologic and treatment factors that individually and in combination predict for an increased risk of local recurrence after breast conserving surgery can be identified, none so obviously compromises survival that breast conservation is contraindicated because that risk factor is present. In-brea...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Osteen RT

    更新日期:1994-01-01 00:00:00

  • The Scale-Up of the Global Surgical Workforce: Can Estimates be Achieved by 2030?

    abstract:BACKGROUND:The Lancet Commission on Global Surgery showed that countries with surgeon, anesthetist, and obstetrician (SAO) densities of 20-40 SAO/100,000 population were associated with improved health outcomes and recommended a global surgical workforce scale-up by 2030. Whether countries would be able to achieve such...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Daniels KM,Riesel JN,Verguet S,Meara JG,Shrime MG

    更新日期:2020-04-01 00:00:00

  • Assessment of quality of life after gastrectomy using EORTC QLQ-C30 and STO22.

    abstract:BACKGROUND:The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Cancer (QLQ-C30) and the site-specific module for gastric cancer (QLQ-STO22) have seldom been used to measure the postoperative health-related quality of life (HRQOL) in Japanese gastric cancer patients. The ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Kobayashi D,Kodera Y,Fujiwara M,Koike M,Nakayama G,Nakao A

    更新日期:2011-02-01 00:00:00

  • Postmastectomy morbidity after combination preoperative irradiation and chemotherapy for locally advanced breast cancer.

    abstract::Neoadjuvant therapy for locally advanced breast cancer improves disease control, but the complications of treatment are not well established. The aim of this study was to assess the operative morbidity in 20 consecutive patients with locally advanced, noninflammatory breast cancer treated with preoperative chemotherap...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Sauter ER,Eisenberg BL,Hoffman JP,Ottery FD,Boraas MC,Goldstein LJ,Solin LJ

    更新日期:1993-03-01 00:00:00

  • Building a comprehensive genomic program for hepatocellular carcinoma.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary liver cancer, causing approximately 660,000 deaths worldwide annually. The preferred treatment of HCC is surgical resection or orthotopic liver transplantation (OLT) for patients meeting specific criteria. For patients outside these criteria, options ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Harring TR,Guiteau JJ,Nguyen NT,Cotton RT,Gingras MC,Wheeler DA,O'Mahony CA,Gibbs RA,Brunicardi FC,Goss JA

    更新日期:2011-08-01 00:00:00

  • The Positive Lymph Node Number and Postoperative N-Staging Used to Estimate Survival in Patients with Differentiated Thyroid Cancer: Results from the Surveillance, Epidemiology, and End Results Dataset (1988-2008).

    abstract:BACKGROUND:Lymph node metastasis is important when evaluating the prognosis of patients with differentiated thyroid cancer (DTC). However, the current N-staging system cannot fully reflect the clinical significance of cervical lymph node metastasis in DTC. In this study, we employed Surveillance, Epidemiology, and End ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Wei WJ,Lu ZW,Wen D,Liao T,Li DS,Wang Y,Zhu YX,Wang ZY,Wu Y,Wang YL,Ji QH

    更新日期:2018-06-01 00:00:00

  • Long-term results of laparoscopic hepatectomy versus open hepatectomy for hepatocellular carcinoma: a case-matched analysis.

    abstract:BACKGROUND:Laparoscopic hepatectomy (LH) is established as a safe and feasible treatment option for liver tumors. However, whether the adoption of laparoscopic approach for malignant tumors, such as hepatocellular carcinoma (HCC), will compromise the long-term result is still unknown. This study was designed to evaluat...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Lee KF,Chong CN,Wong J,Cheung YS,Wong J,Lai P

    更新日期:2011-10-01 00:00:00

  • Endoscopic sphincterotomy: 7-year experience.

    abstract::The present study documents the indications and results of endoscopic sphincterotomy (ES) performed over 7 years in a surgical endoscopy unit. Potential improvement of results over this time period was analyzed. ES was associated with rare but undesirable morbidity and mortality. Specific improvement of results over t...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Lo CY,Lai EC,Lo CM,Mok FP,Chu KM,Liu CL,Fan ST

    更新日期:1997-01-01 00:00:00

  • Modified technique of laparoscopic intraperitoneal hernioplasty for irreducible scrotal hernias (omentoceles): how to remove the hernial contents.

    abstract:INTRODUCTION:The surgical repair of large irreducible scrotal hernias is, in general, technically difficult. Laparoscopic repair for these cases is controversial, although extraperitoneal and transperitoneal approaches have been described. We present a small series of patients with large irreducible groin hernias (omen...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Palanivelu C,Rangarajan M,John SJ

    更新日期:2007-09-01 00:00:00

  • Laparoscopic fundoplication with prosthetic hiatal closure.

    abstract:BACKGROUND:Despite the good results reported after laparoscopic fundoplication, failure is still a major problem. Hiatal disruption is one of the common patterns of anatomical failure. The aim of this study was to compare the results of suture repair of diaphragmatic crura with routine polypropylene mesh reinforcement ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Turkcapar A,Kepenekci I,Mahmoud H,Tuzuner A

    更新日期:2007-11-01 00:00:00

  • Clinical and radiologic evaluation of foramen of Morgagni hernias and the transthoracic approach.

    abstract::The limited number of publications on repair of the foramen of Morgagni hernia concentrates mainly on the laparotomy approach. We present our experience with the transthoracic approach. Patients who were diagnosed as having a foramen of Morgagni hernia and were operated on via the transthoracic approach between Decemb...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Sirmali M,Türüt H,Gezer S,Findik G,Kaya S,Tastepe Y,Cetin G

    更新日期:2005-11-01 00:00:00

  • Special variants of differentiated thyroid cancer: does it alter the extent of surgery versus well-differentiated thyroid cancer?

    abstract:INTRODUCTION:Recently, more aggressive variants of so-called well-differentiated thyroid carcinomas have been identified such as the tall cell variant, columnar cell variant, diffuse sclerosing variant, insular carcinoma, and Hürthle cell (oncocytic, oxyphilic) carcinomas. METHODS:An evidence-based review was performe...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Carling T,Ocal IT,Udelsman R

    更新日期:2007-05-01 00:00:00

  • Effect of oral glutamine administration on bacterial tanslocation, endotoxemia, liver and ileal morphology, and apoptosis in rats with obstructive jaundice.

    abstract::Postoperative complications in patients with obstructive jaundice remain increased when associated with endotoxemia and the inflammatory response due to gut barrier failure. Administration of glutamine has been proposed to maintain the integrity of the gut mucosa and thus reduce bacterial translocation (BT), but the e...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Margaritis VG,Filos KS,Michalaki MA,Scopa CD,Spiliopoulou I,Nikolopoulou VN,Vagianos CE

    更新日期:2005-10-01 00:00:00

  • What Exactly is Meant by "Loss of Domain" for Ventral Hernia? Systematic Review of Definitions.

    abstract::Large ventral hernias are a significant surgical challenge. "Loss of domain" (LOD) expresses the relationship between hernia and abdominal volume, and is used to predict operative difficulty and success. This systematic review assessed whether different definitions of LOD are used in the literature. The PubMed databas...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Parker SG,Halligan S,Blackburn S,Plumb AAO,Archer L,Mallett S,Windsor ACJ

    更新日期:2019-02-01 00:00:00

  • Does Nissen Fundoplication Provide Lifelong Reflux Control? Symptomatic Outcome After 31-33 Years.

    abstract:BACKGROUND:A substantial number of people are suffering from gastroesophageal reflux disease (GERD). The indication for surgical treatment is the failure of medical treatment in patients with objectively verified GERD. The use of PPIs has been noted to increase with the length of follow-up after fundoplication, raising...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Neuvonen P,Sand J,Matikainen M,Rantanen T

    更新日期:2017-08-01 00:00:00

  • Central Hepatectomy versus Extended Hepatectomy for Malignant Tumors: A Propensity Score Analysis of Postoperative Complications.

    abstract:BACKGROUND:The specific definition of central hepatectomy (CH) (i.e., resection of segments 4-5-8 ± 1) is not uniformly used, resulting in conflicting comparisons with the more commonly performed extended hepatectomy (EH). The study aimed to compare, using propensity score matching (PSM) analysis, the incidence of post...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: de'Angelis N,Pascal G,Salloum C,Lahat E,Ichai P,Saliba F,Adam R,Castaing D,Azoulay D

    更新日期:2016-11-01 00:00:00

  • Geographical aspects of peptic ulcer surgery.

    abstract::The geographic distribution of duodenal ulcer and its characteristics in rural areas of high incidence in developing countries are reviewed. The choice of surgical procedures is discussed in light of the bulky diet and nutritional problems of these countries. A vagotomy procedure is advised for duodenal ulcer and a B...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Tovey FI

    更新日期:1977-01-01 00:00:00

  • Vascular thoracic outlet syndrome.

    abstract::The surgical treatment of 30 cases of vascular thoracic outlet syndrome (TOS) in 25 patients is presented. Patients included 17 women and 8 men with average age of 26.1 years. The causes of compression were cervical rib ( n = 16), soft tissue anomalies ( n = 12), and scar tissue after clavicle fracture ( n = 2). Ten s...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Davidovic LB,Kostic DM,Jakovljevic NS,Kuzmanovic IL,Simic TM

    更新日期:2003-05-01 00:00:00

  • Flow disruptions during trauma care.

    abstract:BACKGROUND:Flow disruptions (FDs) are deviations from the progression of care that compromise safety or efficiency. The frequency and specific causes of FDs remain poorly documented in trauma care. We undertook this study to identify and quantify the rate of FDs during various phases of trauma care. METHODS:Seven trai...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Shouhed D,Blocker R,Gangi A,Ley E,Blaha J,Margulies D,Wiegmann DA,Starnes B,Karl C,Karl R,Gewertz BL,Catchpole KR

    更新日期:2014-02-01 00:00:00

  • Surgical management of malignant islet cell tumors.

    abstract::The surgical management of pancreatic islet cell carcinomas poses a complicated set of questions resulting from their rare occurrence and the difficulty in establishing a diagnosis in early cases or, conversely, the problems inherent in dealing with metastatic disease. However, because their biologic behavior is rathe...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Grant CS

    更新日期:1993-07-01 00:00:00

  • Access routes for nutritional therapy.

    abstract::Enteral nutrition (EN) and total parenteral nutrition (TPN) may provide life-sustaining therapy for surgical patients. The duration of nutritional therapy (enteral or parenteral) implies distinct access routes. We review the main aspects related to access routes for nutrient delivery. The enteral route, whenever feasi...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Waitzberg DL,Plopper C,Terra RM

    更新日期:2000-12-01 00:00:00

  • Head injury in the United Kingdom.

    abstract::This paper reviews aspects of head injury management and research in the United Kingdom (UK). We discuss evidence about the scale and etiology of head injury in Britain and how this information has supported a triage-based approach, incorporating risk analysis. A Cohesive organization based upon nationally accepted, y...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Kay A,Teasdale G

    更新日期:2001-09-01 00:00:00

  • Prognostic relevance of survivin in pancreatic endocrine tumors.

    abstract:BACKGROUND:Better prognostic markers are needed for pancreatic endocrine tumors. Survivin is an apoptosis inhibitor that is suggested to have a negative prognostic impact in several tumor types. Contradictory data exist, especially regarding the significance of a nuclear versus cytoplasmic location of survivin. The pro...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Ekeblad S,Lejonklou MH,Stålberg P,Skogseid B

    更新日期:2012-06-01 00:00:00

  • The evolving role of laparoscopy in colonic diverticular disease: a systematic review.

    abstract:BACKGROUND:A PubMed search of the biomedical literature was carried out to systematically review the role of laparoscopy in colonic diverticular disease. All original reports comparing elective laparoscopic, hand-assisted, and open colon resection for diverticular disease of the colon, as well as original reports evalu...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Gaertner WB,Kwaan MR,Madoff RD,Willis D,Belzer GE,Rothenberger DA,Melton GB

    更新日期:2013-03-01 00:00:00