Efficacy of HOCl scavenging by sulfur-containing compounds: antioxidant activity of glutathione disulfide?

Abstract:

:Hypochlorous acid (HOCl) is a bactericidal compound formed by activated neutrophils during inflammation. Overproduction of HOCl causes damage to tissues at the site of neutrophil accumulation. The deleterious effects of excessive HOCl formation can be attenuated using antioxidants. Thiols and thioethers are known to be very effective HOCl scavengers. In the present study, the potency of several sulfur-containing compounds to protect acetylcholinesterase, glutathione S-transferase P1-1 (GST P1-1) and alpha1-antiproteinease against inactivation by HOCl was determined. Surprisingly, glutathione disulfide was an effective protector of acetylcholinesterase against hypochlorous acid. Glutathione disulfide did not provide protection for GST P1-1 and alpha1-antiproteinease against oxidative inactivation by HOCl. The implications of this finding are discussed.

journal_name

Biol Chem

journal_title

Biological chemistry

authors

den Hartog GJ,Haenen GR,Vegt E,van der Vijgh WJ,Bast A

doi

10.1515/BC.2002.073

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

709-13

issue

3-4

eissn

1431-6730

issn

1437-4315

journal_volume

383

pub_type

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