Long-term follow-up after radiofrequency catheter ablation of ventricular tachycardia: a successful approach?


INTRODUCTION:Radiofrequency ablation (RFCA) of ventricular tachycardia (VT) is a potential curative treatment modality. We evaluated the results of RFCA in patients with VT. METHODS AND RESULTS:One hundred fifty-one consecutive patients (122 men and 29 women; age 57 +/- 16 years) with drug-refractory VT were treated. Underlying heart disease was ischemic heart disease in 89 (59%), arrhythmogenic right ventricular cardiomyopathy (ARVC) in 32 (21%), and idiopathic VT in 30 (20%; left ventricle in 9 [30%]; right ventricle in 21 [70%]). Ablation was performed using standard ablation techniques. Three hundred six different VTs were treated (cycle length 334 +/- 87 msec, 2.0 +/- 1.4 VTs per patient). Procedural success (noninducibility of VT after RFCA) was achieved in 126 (83%) patients (70 ischemic heart disease [79%]; 28 ARVC [88%]; 27 idiopathic VT [93%]). Procedure-related complications (< 48 hours) occurred in 11 (7%) patients: death 3 (2.0%), cerebrovascular accident 2 (1.3%), complete heart block 4 (2.6%), and pericardial effusion 3 (2.0%). Thirty-three (22%) patients received an implantable cardioverter defibrillator (because of hemodynamic unstable VT, failure of the procedure, or aborted sudden death). During follow-up (34 +/- 11 months), VT recurrences occurred in 38 (26%) patients (recurrence rate: 19% in successfully ablated patients and 64% in nonsuccessfully ablated patients; P < 0.001). During follow-up, 12 (8%) patients died (heart failure 8, unknown cause 1, noncardiac cause 3). CONCLUSION:RFCA of VT can be performed with a high degree of success (83%). The long-term outcome of successfully ablated patients is promising, with a 75% relative risk reduction compared with nonsuccessfully ablated patients. During follow-up, only one patient died suddenly, supporting a selective ICD placement approach in patients with hemodynamically stable VT.


Borger van der Burg AE,de Groot NM,van Erven L,Bootsma M,van der Wall EE,Schalij MJ





Has Abstract


2002-05-01 00:00:00












  • Block of I(Ks) does not induce early afterdepolarization activity but promotes beta-adrenergic agonist-induced delayed afterdepolarization activity.

    abstract:INTRODUCTION:An early afterdepolarization (EAD)-induced triggered beat is thought to precipitate torsade de pointes (TdP) in the long QT syndrome (LQTS). Previous studies demonstrated the development of EAD activity and dispersion of repolarization under LQT2 (reduced I(Kr)) and LQT3 (augmented late I(Na)), but not LQT...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Burashnikov A,Antzelevitch C

    更新日期:2000-04-01 00:00:00

  • Pharmacologic management of atrial fibrillation.

    abstract::In an era when many electrophysiologic problems are routinely treated with invasive procedures or implantable devices, drugs remain the cornerstones of treatment for atrial fibrillation. Atrial fibrillation may present as an episodic rhythm in patients who are primarily in sinus rhythm or it may be manifested as rhyth...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审


    authors: Riley RD,Pritchett EL

    更新日期:1997-07-01 00:00:00

  • Long-term efficacy and safety of two different rhythm control strategies in elderly patients with symptomatic persistent atrial fibrillation.

    abstract:BACKGROUND:We prospectively compared the efficacy, safety, and quality of life (QoL) impact of catheter ablation versus antiarrhythmic drugs (AAD) in elderly patients with persistent atrial fibrillation (AF). METHODS AND RESULTS:Four hundred and twelve consecutive patients, aged ≥ 70 years, underwent ablation (Group A...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 临床试验,杂志文章


    authors: Blandino A,Toso E,Scaglione M,Anselmino M,Ferraris F,Sardi D,Battaglia A,Gaita F

    更新日期:2013-07-01 00:00:00

  • Correlative anatomy for the electrophysiologist, Part I: the pericardial space, oblique sinus, transverse sinus.

    abstract::There is an increasing need for invasive electrophysiologists to appreciate the exact anatomy of the epicardial space and the coronary veins. The location of the epicardial fat, the complementary relationship with the main cardiac veins, and the location of sensitive structures (arteries, phrenic nerve, esophagus) hav...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审


    authors: Lachman N,Syed FF,Habib A,Kapa S,Bisco SE,Venkatachalam KL,Asirvatham SJ

    更新日期:2010-12-01 00:00:00

  • Incidence of atrial fibrillation in heart transplant patients: long-term follow-up.

    abstract:BACKGROUND:The incidence of atrial fibrillation (AF) in heart transplant patients has not been well documented. METHODS:To determine the incidence of AF in a cohort of patients undergoing cardiac transplantation, clinical data were obtained from a prospectively collected database for all consecutive orthotopic heart t...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Khan M,Kalahasti V,Rajagopal V,Khaykin Y,Wazni O,Almahameed S,Zuzek R,Shah T,Lakkireddy D,Saliba W,Schweikert R,Cummings J,Martin DO,Natale A

    更新日期:2006-08-01 00:00:00

  • Substrate characterization and catheter ablation for monomorphic ventricular tachycardia in patients with apical hypertrophic cardiomyopathy.

    abstract:UNLABELLED:VT Ablation in Apical Hypertrophic Cardiomyopathy.  INTRODUCTION:Monomorphic ventricular tachycardia (VT) is uncommon in apical hypertrophic cardiomyopathy (HCM). The purpose of this study was to define the substrate and role of catheter ablation for VT in apical HCM. METHODS:Four patients with apical HCM ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Inada K,Seiler J,Roberts-Thomson KC,Steven D,Rosman J,John RM,Sobieszczyk P,Stevenson WG,Tedrow UB

    更新日期:2011-01-01 00:00:00

  • Drug-induced torsades de pointes and implications for drug development.

    abstract::Torsades de pointes is a potentially lethal arrhythmia that occasionally appears as an adverse effect of pharmacotherapy. Recently developed understanding of the underlying electrophysiology allows better estimation of the drug-induced risks and explains the failures of older approaches through the surface ECG. This a...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审


    authors: Fenichel RR,Malik M,Antzelevitch C,Sanguinetti M,Roden DM,Priori SG,Ruskin JN,Lipicky RJ,Cantilena LR,Independent Academic Task Force.

    更新日期:2004-04-01 00:00:00

  • Regional isolation in the right atrium with disruption of intra-atrial conduction after catheter ablation of atrial tachycardia.

    abstract:BACKGROUND:Ablation of atrial tachycardia (AT) that occurs after cardiac surgery or prior ablation often requires complex lesion sets. In combination with the pre-existing atrial scar, these lesion sets may result in inadvertent intra-atrial conduction block. This study reports the phenomenon of incidental isolation of...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Markowitz SM,Choi DY,Daian F,Liu CF,Cheung JW,Thomas G,Ip JE,Lerman BB

    更新日期:2019-10-01 00:00:00

  • Effects of temporal application parameters on lesion dimensions during transvenous catheter cryoablation.

    abstract:UNLABELLED:Lesion dimension of cryoablation. BACKGROUND:Transvenous catheter cryoablation is a novel technique for treating cardiac arrhythmias. However, the relative importance of temporal application parameters on lesion dimension and clinical efficacy has not been studied. METHODS AND RESULTS:We investigated the e...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Tse HF,Ripley KL,Lee KL,Siu CW,Van Vleet JF,Pelkey WL,Lau CP

    更新日期:2005-02-01 00:00:00

  • Paradoxical undersensing during atrial flutter: what is the mechanism?

    abstract::A patient with congenital complete heart block underwent implantation of a dual-chamber pacemaker. He presented to the emergency room with fatigue and was found to be in atrial flutter. Device interrogation revealed undersensing of 5 mV flutter waves at a programmed sensitivity of 0.5 mV. Due to undersensing, mode swi...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Kalahasty G,Kenigsberg DN,Wood MA,Ellenbogen KA

    更新日期:2006-11-01 00:00:00

  • Is there a potential benefit to increased irrigation channels during radiofrequency ablation? Results from a two-center prospective randomized study.

    abstract:INTRODUCTION:Open irrigation during radiofrequency (RF) application allows a higher power delivery in the setting of temperature-controlled ablation, without causing blood clots. This study sought to evaluate the clinical value of the additional 6 supplementary channels at the proximal catheter tip compared to a standa...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Knecht S,Sacher F,Forclaz A,Verbeet T,Hocini M,Wright M,Tran-Ngoc E,Morissens M,Peperstraete B,Derval N,Jaïs P,Linton N,Decoodt P,Haïssaguerre M,Castro-Rodriguez J

    更新日期:2011-05-01 00:00:00

  • Acute atrial dilatation slows conduction and increases AF vulnerability in the human atrium.

    abstract:INTRODUCTION:The mechanisms by which atrial stretch favors the development of a substrate for atrial fibrillation (AF) are not fully understood. In this study, the role of stretch-induced conduction changes in the creation of a proarrhythmic substrate has been investigated by quantifying the spatial distribution of loc...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Ravelli F,Masè M,del Greco M,Marini M,Disertori M

    更新日期:2011-04-01 00:00:00

  • Outcomes after cardiac perforation during radiofrequency ablation of the atrium.

    abstract:BACKGROUND:Perforation during catheter procedures in either the atrium or ventricle is relatively uncommon, but potentially fatal if tamponade ensues. This study analyzes the occurrence and outcomes of cardiac perforation during catheter-based radiofrequency ablation procedures in the left atrium. METHODS:All patients...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Bunch TJ,Asirvatham SJ,Friedman PA,Monahan KH,Munger TM,Rea RF,Sinak LJ,Packer DL

    更新日期:2005-11-01 00:00:00

  • Characterization of a novel missense mutation in the pore of HERG in a patient with long QT syndrome.

    abstract:INTRODUCTION:A new strategy to elucidate the molecular mechanisms underlying the long QT syndrome (LQTS) is now available with genetic mutational analyses and characterization of ion channel mutations. METHODS AND RESULTS:In a 26-year-old woman with LQTS, we identified a novel missense mutation in the pore of HERG by ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Yoshida H,Horie M,Otani H,Takano M,Tsuji K,Kubota T,Fukunami M,Sasayama S

    更新日期:1999-09-01 00:00:00

  • Hypoxia and hypothermia enhance spatial heterogeneities of repolarization in guinea pig hearts: analysis of spatial autocorrelation of optically recorded action potential durations.

    abstract:INTRODUCTION:Regional dispersions of repolarization (DOR) are arrhythmogenic perturbations that are closely associated with reentry. However, the characteristics of DOR have not been well defined or adequately analyzed because previous algorithms did not take into account spatial heterogeneities of action potential dur...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Salama G,Kanai AJ,Huang D,Efimov IR,Girouard SD,Rosenbaum DS

    更新日期:1998-02-01 00:00:00

  • Paradoxical effects of interatrial conduction delay in a hypertrophic cardiomyopathy patient in the long-term: time is a great healer.

    abstract::We present a unique case where early proarrhythmic and late antiarrhythmic characteristics of interatrial conduction delay were observed during the long-term progression of HCM. Occurrence of AT constantly increased as the interatrial conduction delay became more prominent, while the P-wave width in sinus rhythm and t...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Bauernfeind T,Caliskan K,Vletter WB,Ten Cate FJ,Dabiri L,de Groot N,Jordaens L,Szili-Torok T

    更新日期:2011-05-01 00:00:00

  • Histopathological Study of Left and Right Atria in Isolated Rheumatic Mitral Stenosis With and Without Atrial Fibrillation.

    abstract:BACKGROUND:Mitral stenosis (MS) has the highest incidence of atrial fibrillation (AF) in chronic rheumatic valvular disease. There are very few studies in isolated MS comparing histopathological changes in patients with sinus rhythm (SR) and AF. OBJECTIVES:To analyze the histological changes associated with isolated M...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Shenthar J,Kalpana SR,Prabhu MA,Rai MK,Nagashetty RK,Kamlapurkar G

    更新日期:2016-09-01 00:00:00

  • The signal-averaged electrocardiogram: update on clinical applications.

    abstract::The signal-averaged electrocardiogram (SAECG) facilitates noninvasive recording of low-amplitude cardiac signals such as ventricular late potentials. The SAECG has been used to accurately predict life-threatening ventricular tachyarrhythmias in patients after acute myocardial infarction and with nonischemic dilated ca...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审


    authors: Steinberg JS,Berbari EJ

    更新日期:1996-10-01 00:00:00

  • Differential effect of beta-adrenergic stimulation on the frequency-dependent electrophysiologic actions of the new class III antiarrhythmics dofetilide, ambasilide, and chromanol 293B.

    abstract:INTRODUCTION:Blockade of the rapid delayed rectifier potassium current (IKr) as an important mechanism for current Class III antiarrhythmics is less effective in action potential prolongation during beta-adrenergic activation. We hypothesized that blockade of the increased slow IK (IKs) current during beta-adrenergic s...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Schreieck J,Wang Y,Gjini V,Korth M,Zrenner B,Schömig A,Schmitt C

    更新日期:1997-12-01 00:00:00

  • Age of first faint in patients with vasovagal syncope.

    abstract:INTRODUCTION:Understanding whether vasovagal syncope is a lifelong disorder might shed insight into its physiology and affect management strategies. Accordingly, we determined the age of the first syncopal spell in adult patients who sought care for syncope. METHODS AND RESULTS:Patients were 42 +/- 18 years old with 6...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,多中心研究


    authors: Sheldon RS,Sheldon AG,Connolly SJ,Morillo CA,Klingenheben T,Krahn AD,Koshman ML,Ritchie D,Investigators of the Syncope Symptom Study and the Prevention of Syncope Trial.

    更新日期:2006-01-01 00:00:00

  • Radiofrequency catheter ablation of left ventricular outflow tract tachycardia from the coronary cusp: a new approach to the tachycardia focus.

    abstract:INTRODUCTION:Idiopathic ventricular tachycardia (VT) originating from the left ventricular outflow tract (LVOT) is rare. Previously reported were two cases of LVOT tachycardia which were treated with radiofrequency (RF) catheter ablation through endocardial aortomitral continuity. We report here a case of a repetitive ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Shimoike E,Ohnishi Y,Ueda N,Maruyama T,Kaji Y

    更新日期:1999-07-01 00:00:00

  • Catheter ablation of common-type atrial flutter guided by three-dimensional right atrial geometry reconstruction and catheter tracking using cutaneous patches: a randomized prospective study.

    abstract:INTRODUCTION:EnSite NavX (NavX) is a novel mapping and navigation system that allows visualization of conventional catheters for diagnostic and ablative purposes and uses them to create a three-dimensional (3D) geometry of the heart. NavX is particularly suitable for ablation procedures utilizing an anatomic approach, ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ventura R,Rostock T,Klemm HU,Lutomsky B,Demir C,Weiss C,Meinertz T,Willems S

    更新日期:2004-10-01 00:00:00

  • Droperidol lengthens cardiac repolarization due to block of the rapid component of the delayed rectifier potassium current.

    abstract:INTRODUCTION:Torsades de pointes have been observed during treatment with droperidol, a butyrophenone neuroleptic agent. Our objectives were (1) to characterize the effects of droperidol on cardiac repolarization and (2) to evaluate effects of droperidol on a major time-dependent outward potassium current involved in c...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Drolet B,Zhang S,Deschênes D,Rail J,Nadeau S,Zhou Z,January CT,Turgeon J

    更新日期:1999-12-01 00:00:00

  • Clinical characteristics and management of periesophageal vagal nerve injury complicating left atrial ablation of atrial fibrillation: lessons from eleven cases.

    abstract:INTRODUCTION:This study aimed to elucidate the clinical characteristics and management of periesophageal vagal nerve injury complicating the ablation of atrial fibrillation (AF). METHODS AND RESULTS:A total of 3,695 patients with drug-resistant AF underwent extensive pulmonary vein isolation at our institution. Either...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Kuwahara T,Takahashi A,Takahashi Y,Kobori A,Miyazaki S,Takei A,Fujino T,Okubo K,Takagi K,Fujii A,Takigawa M,Watari Y,Hikita H,Sato A,Aonuma K

    更新日期:2013-08-01 00:00:00

  • Impact of Remote Monitoring on Clinical Outcomes.

    abstract::Follow-up of patients with cardiac implantable electronic devices is challenging due to both their increasing volume and technical complexity coupled to increasing clinical complexity of recipient patients. Remote monitoring (RM) offers an opportunity to resolve some of these difficulties by improving clinic efficienc...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审


    authors: Varma N,Ricci RP

    更新日期:2015-12-01 00:00:00

  • Baseline B-type natriuretic peptide: a gender-specific predictor of procedure-outcome in atrial fibrillation patients undergoing catheter ablation.

    abstract:BACKGROUND:Close association between atrial fibrillation (AF) and brain natriuretic peptide (BNP) has been demonstrated by several studies. Important gender differences exist in AF patients including a higher plasma BNP level in women. Therefore, it is imperative to evaluate the relationship between AF and BNP separate...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Mohanty S,Mohanty P,Di Biase L,Rong B,Burkhardt D,Gallinghouse JG,Horton R,Sanchez JE,Bailey S,Zagrodzky J,Natale A

    更新日期:2011-08-01 00:00:00

  • Interactions between two simultaneous tachycardias within an electrically isolated pulmonary vein.

    abstract::Pulmonary vein (PV) arrhythmogenicity underlying the maintenance of atrial fibrillation (AF) may be explained by three mechanisms: enhanced automaticity, triggered activity, and reentry. There are only a few reports describing sustained PV tachycardias (PVT) following electrical disconnection from the left atrium, in ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Rostock T,O'Neill MD,Takahashi Y,Sanders P,Haïssaguerre M

    更新日期:2007-04-01 00:00:00

  • Pace-termination and pacing for prevention of atrial tachyarrhythmias: results from a multicenter study with an implantable device for atrial therapy.

    abstract:INTRODUCTION:Patients with bradycardia requiring permanent pacing frequently suffer from additional atrial tachyarrhythmias (ATs). This study evaluated the safety and efficacy of atrial antitachycardia pacing (ATP) and the performance of pacing for AT prevention implemented into a new pacemaker. METHODS AND RESULTS:In...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Israel CW,Hügl B,Unterberg C,Lawo T,Kennis I,Hettrick D,Hohnloser SH,AT500 Verification Study Investigators.

    更新日期:2001-10-01 00:00:00

  • Responses of the transmembrane potential of myocardial cells during a shock.

    abstract:INTRODUCTION:The purpose of this investigation was to study the transmembrane potential changes (delta Vm) during extracellular electrical field stimulation. METHODS AND RESULTS:Vm was recorded in seven guinea pig papillary muscles in a tissue bath by a double-barrel microelectrode with one barrel in and the other jus...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Zhou X,Rollins DL,Smith WM,Ideker RE

    更新日期:1995-04-01 00:00:00

  • On the use of CartoSound for left atrial navigation.

    abstract:INTRODUCTION:The utility of "virtual" imaging systems for left atrial (LA) navigation has been hampered by inadequate spatial detail, as well as inaccurate integration of more detailed preoperative images, such as those generated by computed tomography (CT). CartoSound is an intracardiac echocardiography (ICE)-based te...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章


    authors: Schwartzman D,Zhong H

    更新日期:2010-06-01 00:00:00