Colloid infusion in the perinatal period and abnormal neurodevelopmental outcome in very low birth weight infants.


UNLABELLED:In very low birth weight (VLBW) infants, colloid infusion is associated with impaired perinatal lung function and increased oxygen dependency duration. The aim of this study was to determine whether perinatal colloid infusion was associated with abnormal neurodevelopmental outcome. All perinatal fluid input (crystalloid and colloid) given to VLBW infants entered into a randomised trial was recorded. At 1 and/or 2 years, the neurodevelopmental status of VLBW infants was routinely assessed. Of 131 survivors, median gestational age 27 weeks (range 23-33 weeks), 95 were seen at follow-up. Nineteen had abnormal neurodevelopmental outcome and differed significantly from the rest of the cohort with regard to their birth weight, magnitude of colloid infusion received and the proportions who had received postnatal steroids, suffered prolonged oxygen dependency or having had intracerebral haemorrhage/periventricular leucomalacia development. Regression analysis demonstrated that only colloid infusion related significantly to abnormal neurodevelopmental outcome independent of other variables. CONCLUSION:These data suggest that colloid infusion should be used with caution in the perinatal period.


Eur J Pediatr


Greenough A,Cheeseman P,Kavvadia V,Dimitriou G,Morton M





Has Abstract


2002-06-01 00:00:00












  • Cardiovascular changes in children with mucopolysaccharide storage diseases and related disorders--clinical and echocardiographic findings in 64 patients.

    abstract::Cardiovascular abnormalities were evaluated in 64 children aged between 1 year 9 months and 25 years with mucopolysaccharidoses (MPS) and related disorders. A heart murmur was heard in 18 patients, but in only 6 was it characteristic for specific valvular lesions. Echocardiography was performed in 63 children. In one ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Dangel JH

    更新日期:1998-07-01 00:00:00

  • Evaluation of human chorionic gonadotropin stimulation tests in prepubertal and early pubertal boys.

    abstract::We evaluated the diagnostic significance of single versus repeated human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis in 25 boys (10 prepubertal group A; 15 early pubertal, group B) with suspected hypogonadism. All subjects received a single injection of hCG (5000 U/1.7 m2) and 1 month later,...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章


    authors: Kauschansky A,Frydman M,Nussinovitch M,Varsano I

    更新日期:1995-11-01 00:00:00

  • Granulocyte colony-stimulating factor receptor expression on neutrophils of term and preterm neonates with and without signs of infection.

    abstract:UNLABELLED:Neutrophils are an essential component of the human host defence system against infection. Recombinant human granulocyte colony-stimulating factor induces neutrophilia and enhances effector functions of mature neutrophils. Since the biological effects of granulocyte colony-stimulating factor (G-CSF) are medi...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Gessler P,Neu S,Nebe T,Speer CP

    更新日期:1999-06-01 00:00:00

  • Two hyperandrogenic adolescent girls with congenital portosystemic shunt.

    abstract:UNLABELLED:We describe two adolescent girls with a congenital portosystemic shunt who exhibited hyperandrogenism in addition to insulin resistant hyperinsulinaemia. Case 1 was referred to our clinic to undergo a routine clinical work-up prior to tonsillectomy at 14 years of age. Mild liver dysfunction was identified an...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Satoh M,Yokoya S,Hachiya Y,Hachiya M,Fujisawa T,Hoshino K,Saji T

    更新日期:2001-05-01 00:00:00

  • Hypertension associated with skeletal traction in children.

    abstract::Since traction-associated hypertension seems to be a relatively unknown phenomenon, a survey was done of its incidence in children treated with skeletal traction for fractures and orthopaedic diseases. The correlation with hypercalcaemia, a possible aetiological factor, was also explored. Blood pressure was recorded t...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Heij HA,Ekkelkamp S,Vos A

    更新日期:1992-07-01 00:00:00

  • Pentoxifylline reduces plasma tumour necrosis factor-alpha concentration in premature infants with sepsis.

    abstract:UNLABELLED:Increased plasma tumour necrosis factor alpha (TNF) concentration correlates with mortality in sepsis. We suggested that pentoxifylline (PTXF), which is known to inhibit TNF production, may improve survival and attenuate clinical symptoms of sepsis in neonates. Plasma TNF levels were evaluated in 29 newborn ...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lauterbach R,Zembala M

    更新日期:1996-05-01 00:00:00

  • Neonatal manifestation of multiple sulfatase deficiency.

    abstract:INTRODUCTION:Multiple sulfatase deficiency is biochemically characterized by the accumulation of sulfated lipids and acid mucopolysaccharides. CASE REPORT:We report clinical, biochemical, and molecular findings in a female newborn affected with a severe form of multiple sulfatase deficiency (Mendelian Inheritance in M...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Busche A,Hennermann JB,Bürger F,Proquitté H,Dierks T,von Arnim-Baas A,Horn D

    更新日期:2009-08-01 00:00:00

  • The associations between serum 25-hydroxyvitamin D and red blood cell indices reported from the KiGGS study are, except for mean corpuscular hemoglobin, not mediated by health-related quality of life.

    abstract:: ...

    journal_title:European journal of pediatrics

    pub_type: 信件


    authors: Doudin A,Becker A,Rothenberger A,Meyer T

    更新日期:2018-11-01 00:00:00

  • Transient and permanent neonatal diabetes.

    abstract::Neonatal diabetes, which may be transient or permanent, is rare. Most patients are full-term but small- for-date infants. Typical symptoms of diabetes mellitus occur within the first 4 weeks of life, requiring insulin therapy and very strict blood glucose monitoring. Subsequent growth and psychomotor development are u...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Fösel S

    更新日期:1995-12-01 00:00:00

  • Programmed death-1 (PD-1) gene polymorphisms lodged in the genetic predispositions of Kawasaki Disease.

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    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Chun JK,Kang DW,Yoo BW,Shin JS,Kim DS

    更新日期:2010-02-01 00:00:00

  • Neonatal screening for hypothyroidism in Greece.

    abstract::One year's experience in screening for congenital hypothyroidism in Greece is reported. Thyroid stimulating hormone (TSH) determination by a radioimmunoassay on dried blood spots was selected as the screening method. During the first year of screening 75,879 newborn infants were tested from Guthrie blood spots taken o...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Mengreli C,Kassiou K,Tsagaraki S,Pantelakis S

    更新日期:1981-10-01 00:00:00

  • A glycine 375-to-cysteine substitution in the transmembrane domain of the fibroblast growth factor receptor-3 in a newborn with achondroplasia.

    abstract::Achondroplasia, the most common form of chondrodysplasia, has been associated with mutations in the gene of the fibroblast growth factor receptor-3 (FGFR-3) on chromosome 4p. All 39 achondroplasia alleles studied so far carried point mutations which caused the same amino acid exchange, a substitution of glycine by arg...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Superti-Furga A,Eich G,Bucher HU,Wisser J,Giedion A,Gitzelmann R,Steinmann B

    更新日期:1995-03-01 00:00:00

  • Refining clinical phenotypes in septo-optic dysplasia based on MRI findings.

    abstract::Septo-optic dysplasia (SOD) is a heterogeneous brain midline anomaly associated with ophthalmological, endocrinological, and/or neurodevelopmental symptoms. The clinical phenotype correlates with abnormal brain magnetic resonance imaging (MRI) findings. However, variations of the septum pellucidum (SP) appearance and ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Riedl S,Vosahlo J,Battelino T,Stirn-Kranjc B,Brugger PC,Prayer D,Müllner-Eidenböck A,Kapelari K,Blümel P,Waldhör T,Krasny J,Lebl J,Frisch H

    更新日期:2008-11-01 00:00:00

  • Inconsistencies in the management of neonates born to mothers with "thyroid diseases".

    abstract::Although thyroid medications are frequently prescribed during pregnancy, paediatricians treating the respective neonates often have no information about the underlying maternal thyroid disease, and inconsistencies in postnatal diagnostics may result. We analysed a cohort of 1819 mothers admitted for delivery in 1 year...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Weissenfels PC,Woelfle J,Korsch E,Joergens M,Gohlke B

    更新日期:2018-11-01 00:00:00

  • A mobile Meckel!

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    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: El-Matary W,Roseman D,Lees G,Maguire C

    更新日期:2009-12-01 00:00:00

  • Biliary atresia: the Croatian experience 1992-2006.

    abstract::The objective of this study was to determine the outcomes of Croatian children with biliary atresia. Health records of infants born in Croatia between January 1, 1992 and December 31, 2006 who were diagnosed with biliary atresia and treated at a single university center were reviewed. Survival rates were calculated wi...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Grizelj R,Vuković J,Novak M,Batinica S

    更新日期:2010-12-01 00:00:00

  • Maculopapular rash in the convalescent phase of Kawasaki disease: case series and literature review.

    abstract:UNLABELLED:Intravenous immunoglobulin (IVIG) is currently the standard treatment for Kawasaki disease (KD). Although IVIG therapy is generally well tolerated, several minor adverse reactions have been reported. We report a patient with KD treated with IVIG, who developed a cutaneous reaction in the convalescent phase (...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Takeuchi M,Oda Y,Suzuki I

    更新日期:2013-03-01 00:00:00

  • Intussusception in infants and children: feasibility of ambulatory management.

    abstract::To evaluate the ambulatory management of ileo-colic intussusception in infants and children, a retrospective study over 3 years of 113 children treated for ileo-colic intussusception in a paediatric emergency department was undertaken with the aim of shortening the length of stay. A total of 113 children aged 10 days ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Le Masne A,Lortat-Jacob S,Sayegh N,Sannier N,Brunelle F,Cheron G

    更新日期:1999-09-01 00:00:00

  • Impact of sedentary behavior on large artery structure and function in children and adolescents: a systematic review.

    abstract::Sedentary behavior contributes to increased atherosclerotic risk in adults. Whether or not this can be extended to pediatric populations is unclear. This systematic review assessed associations of sedentary behavior with large artery structure and function in pediatric populations. MEDLINE, EMBASE, CENTRAL, and Web of...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Königstein K,Klenk C,Appenzeller-Herzog C,Hinrichs T,Schmidt-Trucksäss A

    更新日期:2020-01-01 00:00:00

  • Acute neonatal collapse resulting from pericardial effusion.

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    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Bagtharia R,Kempley ST,Hla TM

    更新日期:2001-12-01 00:00:00

  • Thyroid function testing in neonates born to women with hypothyroidism.

    abstract::Our aim was to assess the utility of serum thyroxine and thyroid stimulating hormone performed at 10-14 days of life in diagnosing congenital hypothyroidism (CH) in babies born to mothers with hypothyroidism. This was a retrospective study of all babies born in a tertiary referral centre for neonatology over a 12-mont...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: McGovern M,Reyani Z,O'Connor P,White M,Miletin J

    更新日期:2016-12-01 00:00:00

  • Visual acuity and stereopsis between the ages of 5 and 10 years. A cross-sectional study.

    abstract::The development of visual acuity and stereopsis was studied in 321 boys and 340 girls aged between 5 and 10 years. Visual acuity was assessed by the E test and a modified version of the STYCAR test, stereo acuity by the Lang-Stereo test [17]. Both vision tests showed an increase in the median visual acuity between the...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Schmid M,Largo RH

    更新日期:1986-12-01 00:00:00

  • Evolution of the proportion of patients with Down's syndrome karyotyped in Belgium since 1960.

    abstract::Estimation of the total number of infants with DS born each year in Belgium allows evaluation of changes in the proportion of children with DS in whom a karyotype has been established. This proportion steadily increased to 95% of the children with DS born in 1978. ...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Evers-Kiebooms G,Vlietinck R,van den Berghe H

    更新日期:1985-03-01 00:00:00

  • New insights into lipid and fatty acid metabolism via stable isotopes.

    abstract:UNLABELLED:Dynamic processes are of great interest in the study of lipid and fatty acid metabolism. Their in vivo investigation is now possible with the use of stable isotope tracers and the available sensitive analytical technology. We present some examples demonstrating the assessment of lipid oxidation as well as mo...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Demmelmair H,Sauerwald T,Koletzko B,Richter T

    更新日期:1997-08-01 00:00:00

  • The effect of obesity, age, puberty and gender on resting metabolic rate in children and adolescents.

    abstract:UNLABELLED:During puberty fat-free mass (FFM) and fat mass (FM) change quickly and these changes are influenced by sex and obesity. Since it is not completely known how these changes affect resting metabolic rate (RMR), the aim of the present study was to investigate the effect of body composition, age, sex and puberta...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Molnár D,Schutz Y

    更新日期:1997-05-01 00:00:00

  • Persistent pulmonary hypertension after lithium intoxication in the newborn.

    abstract::A case of lithium intoxication in the newborn is presented. Besides displaying extreme hypotonia and a goitre, the infant developed symptoms of congenital heart disease immediately after birth. Cardiac catheterization and angiocardiography revealed an elevated pulmonary vascular resistance and indicated that the cardi...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Filtenborg JA

    更新日期:1982-07-01 00:00:00

  • Evaluation of triggering systems for patient triggered ventilation for neonates ventilator-dependent beyond 10 days of age.

    abstract::The performance of two triggering systems was compared during patient triggered ventilation (PTV) of infants ventilator-dependent beyond 10 days of age. Ten infants were studied who had a median gestational age of 26.5 weeks and a postnatal age of 15.5 days. PTV was administered via the SLE ventilator and the two trig...

    journal_title:European journal of pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chan V,Greenough A

    更新日期:1992-11-01 00:00:00

  • Mature teratoma arising from intra-abdominal contralateral undescended testis in an infant: a case report.

    abstract::A 4-month-old male infant was seen because of an asymptomatic undescended left testis and a right sided abdominal mass. CT revealed a calcified retroperitoneal tumour. Histological examination of surgical specimens showed a mature primary teratoma of the contralateral undescended testis. While this is very rare, infan...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Azumagawa K,Mimaki T,Tanoue H,Mino M

    更新日期:1993-11-01 00:00:00

  • Overweight and obesity in European children and adolescents.

    abstract::The conclusions of this mini-workshop are not substantially different from those previously published based on the USA experience [9]. This does not necessarily mean that there are no important differences between Europe and the USA, rather it reflects the paucity of data, especially in Europe. Moreover, European data...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章,评审


    authors: Jebb SA,Lambert J

    更新日期:2000-09-01 00:00:00

  • Pulmonary thrombo-embolism in nephrotic syndrome treated with tissue plasminogen activator.

    abstract:UNLABELLED:We describe the case of a boy with steroid sensitive nephrotic syndrome and left pulmonary artery thrombo-embolism. clinical presentation initially suggested sepsis and respiratory signs were minor. Treatment with tissue plasminogen activator infused into the pulmonary artery was successful. CONCLUSION:Pulm...

    journal_title:European journal of pediatrics

    pub_type: 杂志文章


    authors: Reid CJ,Segal T

    更新日期:1997-08-01 00:00:00