Overexpression of hyaluronan synthase-2 reduces the tumorigenic potential of glioma cells lacking hyaluronidase activity.

abstract：:The concept of spinal cord injury has existed since the earliest human civilizations, with the earliest documented cases dating back to 3000 BC under the Egyptian Empire. Howevr, an understanding of this field developed slowly, with real advancements not emerging until the 20th century. Technological advancements incl...

journal_title：Neurosurgery

authors： Thakur JD,Wild E,Menger R,Hefner M,Adeeb N,Kalakoti P,Nanda A

更新日期：2020-06-01 00:00:00

abstract：:Infusion of 25% mannitol into the internal carotid artery of the dog results in a reversible disruption of the blood-brain barrier (BBB). This osmotic BBB disruption enhances the penetratin of systemically administered methotrexate (MTX) into the ipsilateral cerebral hemisphere. Brain methotexate levels were maximized...

journal_title：Neurosurgery

authors： Neuwelt EA,Frenkel EP,Rapoport S,Barnett P

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND AND IMPORTANCE:Although the use of proximal artery occlusion, or hunterian ligation, for the treatment of intracranial aneurysms has decreased greatly over the past decades, this approach still finds use for certain giant and complex aneurysms. The main risks of artery sacrifice are ischemic complications bu...

journal_title：Neurosurgery

authors： Arnaout OM,Rahme RJ,Aoun SG,Daou MR,Batjer HH,Bendok BR

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:Cerebellopontine angle (CPA) epidermoids, although of benign nature, are of considerable neurosurgical interest because of their close proximity and adherence to the cranial nerves and the brain stem. We describe our experience and attempt to correlate the final outcomes with the extent of surgical removal. ...

journal_title：Neurosurgery

authors： Mohanty A,Venkatrama SK,Rao BR,Chandramouli BA,Jayakumar PN,Das BS

更新日期：1997-01-01 00:00:00

abstract：:The first half of the 20th century witnessed the rapid emergence of neurological surgery as a surgical subspecialty. Only few surgeons made a name for themselves equally in general surgery and neurological surgery. One of them was the Swiss surgeon Theodor Kocher (1841-1917). He was honored with the Nobel Prize for hi...

journal_title：Neurosurgery

authors： Schültke E

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:The supraorbital approach is well accepted for lesions in the anterior fossa, the sellar region, and the anterior circle of Willis. However, the usefulness of this approach has not yet been elucidated for lesions in the interpeduncular fossa. The technique of an endoscope-assisted, ipsi- and contralateral sup...

journal_title：Neurosurgery

authors： Menovsky T,Grotenhuis JA,de Vries J,Bartels RH

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Placement of spinal cord stimulating paddle leads has traditionally been performed under local anesthesia with intravenous sedation to allow intraoperative confirmation of appropriate placement. It may be difficult to maintain appropriate sedation in certain patients because of medical comorbidities. Further...

journal_title：Neurosurgery

authors： Mammis A,Mogilner AY

更新日期：2012-06-01 00:00:00

abstract：:Sarcomatous transformation of the enchondromas is a well-known complication of Ollier's disease, and nonsarcomatous malignancies have usually been associated with Maffucci's syndrome. Only 13 cases of multiple enchondromatosis associated with intracranial gliomas have been described, 5 of which were in patients with O...

journal_title：Neurosurgery

authors： Chang S,Prados MD

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Distal middle cerebral artery (MCA) aneurysms frequently have nonsaccular morphology that necessitates trapping and bypass. Bypasses can be difficult because efferent arteries lie deep in the opercular cleft and may not be easily identifiable. OBJECTIVE:We introduce the "flash fluorescence" technique, which...

journal_title：Neurosurgery

authors： Rodríguez-Hernández A,Lawton MT

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:The anterior lumbar interbody fusion (ALIF) procedure has become an accepted fusion technique for treating patients with degenerative disorders of the lumbar spine. Many consider laparoscopic ALIF to be the least invasive approach. A modification of the open laparotomy--the "mini-open" approach--is an attract...

journal_title：Neurosurgery

authors： Kaiser MG,Haid RW Jr,Subach BR,Miller JS,Smith CD,Rodts GE Jr

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:The surgical benefit to pseudo-occlusion of the internal carotid artery (ICA) is controversial. Because the benefit of carotid endarterectomy for pseudo-occlusion of the ICA remains uncertain, we examined the use of carotid stenting as a possible alternative treatment for this condition. METHODS:Twenty cases...

journal_title：Neurosurgery

authors： Terada T,Tsuura M,Matsumoto H,Masuo O,Tsumoto T,Yamaga H,Itakura T

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:Despite advances in surgical techniques in the management of the brain abscess, long-term antibiotics are as crucial to cure as the initial surgical procedure itself. This study was designed to evaluate the effect of adjuvant hyperbaric oxygen (HBO) therapy on the duration of antibiotic treatment. METHODS:Be...

journal_title：Neurosurgery

authors： Kutlay M,Colak A,Yildiz S,Demircan N,Akin ON

更新日期：2008-02-01 00:00:00

abstract：:A case of cerebellar hemorrhage complicating the postoperative course of a patient who had undergone a cervical laminectomy in the sitting position is presented. The drop in cerebrospinal fluid pressure accompanying the procedure is thought to have had some role in the development of the hemorrhage. ...

journal_title：Neurosurgery

authors： Chadduck WM

更新日期：1981-08-01 00:00:00

abstract：:The computed tomographic (CT) scan has replaced angiography in the preoperative neurodiagnostic evaluation of the common pediatric posterior fossa tumors. This case report illustrates that rarely an atypical vascular anomaly may masquerade as a neoplasm and angiography must not be dismissed if the CT scan is any way a...

journal_title：Neurosurgery

authors： Epstein N,Epstein F,Berenstein A

更新日期：1980-06-01 00:00:00

abstract：OBJECTIVE:During the past decade, management of posterior circulation aneurysms has shifted away from microsurgery. Currently, microsurgical clipping is considered a primary, competitive alternative to endovascular coiling, or more commonly, a secondary alternative when endovascular therapy is unfavorable. We present a...

journal_title：Neurosurgery

authors： Sanai N,Tarapore P,Lee AC,Lawton MT

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of gamma knife (GK) radiosurgery, in terms of neurological improvement and tumor growth control (TGC), for a large series of patients with cavernous sinus meningiomas. METHODS:Between February 1993 and January 2002, 156 patients with cavernous sinus meningiomas (35 male and 121 femal...

journal_title：Neurosurgery

authors： Nicolato A,Foroni R,Alessandrini F,Bricolo A,Gerosa M

更新日期：2002-11-01 00:00:00

abstract：:The incidence of intracerebral hematomas after myocardial infarction increases after thrombolysis. As noted in the case described, clots formed after the administration of thrombolytic agents may remain liquid, and this blood can be drained by a catheter. However, in this case, the patient continued to bleed locally. ...

journal_title：Neurosurgery

authors： Kaufman HH,McAllister P,Taylor H,Schmidt S

更新日期：1993-11-01 00:00:00

abstract：:Previous assessments of the value of sequential computed tomographic (CT) scanning in brain tumor patients have suffered from the heterogeneous nature of the study populations in regard to (a) pathology, (b) treatment plan, and (c) time of scanning. This report is based on the first 21 of 30 consecutive cases of gliob...

journal_title：Neurosurgery

authors： Salcman M,Levine H,Rao K

更新日期：1981-01-01 00:00:00

abstract：:There has been a renewed interest in manned spaceflight due to endeavors by private and government agencies. Publicized goals include manned trips to or colonization of Mars. These missions will likely be of long duration, exceeding existing records for human exposure to extra-terrestrial conditions. Participants will...

journal_title：Neurosurgery

authors： Panesar SS,Fernandez-Miranda JC,Kliot M,Ashkan K

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To test the spatial accuracy of coordinates generated from magnetic resonance imaging (MRI) scans, using the Brown-Roberts-Wells head frame and localizer system (Radionics, Inc., Burlington, MA). METHODS:An anthropomorphic head phantom, consisting of a two-dimensional lattice of acrylic spheres (4-mm diamete...

journal_title：Neurosurgery

authors： Orth RC,Sinha P,Madsen EL,Frank G,Korosec FR,Mackie TR,Mehta MP

更新日期：1999-12-01 00:00:00

abstract：:Five intramedullary cavernous angiomas were surgically removed after being localized by intraoperative ultrasound imaging. Two patients were men, and three were women; in three patients, the symptoms had an acute onset, whereas in the other two, it was gradual. The vascular malformation was localized in the dorsal tra...

journal_title：Neurosurgery

authors： Lunardi P,Acqui M,Ferrante L,Fortuna A

更新日期：1994-03-01 00:00:00

abstract：:Cerebral arterial vasospasm continues to be a major secondary medical complication of aneurysmal subarachnoid hemorrhage. Despite hypervolemic hemodilution, arterial hypertension, and pharmacological therapy, morbidity and mortality due to vasospasm remain high. The authors discuss a patient with vasospasm who did not...

journal_title：Neurosurgery

authors： Luer MS,Dujovny M,Slavin KV,Hernandez-Avila G,Ausman JI

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Intrawound vancomycin powder has been studied extensively in spinal fusion surgeries and been found to reduce rates of surgical site infections (SSIs) significantly. Despite its success in spinal surgeries, topical vancomycin has not been extensively studied with respect to cranial neurosurgery. OBJECTIVE:T...

journal_title：Neurosurgery

authors： Ravikumar V,Ho AL,Pendhakar AV,Sussman ES,Kwong-Hon Chow K,Li G

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:To determine if a window of time could be defined during which angioplasty would be most effective in reversing neurological decline and ultimately improving outcome. METHODS:Of a group of 466 patients, 93 underwent endovascular management of clinical vasospasm that was medically refractory. Eighty-four of ...

journal_title：Neurosurgery

authors： Rosenwasser RH,Armonda RA,Thomas JE,Benitez RP,Gannon PM,Harrop J

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the relative socioeconomic costs of benign cranial base tumors treated with open surgery and gamma knife radiosurgery. METHODS:In a retrospective study, we studied 174 patients with benign cranial base tumors, less than 3 cm in diameter (or volume less than 30 ml), admit...

journal_title：Neurosurgery

authors： Cho DY,Tsao M,Lee WY,Chang CS

更新日期：2006-05-01 00:00:00

abstract：:Angiographically equivocal aneurysmal dilatation at the junction of the internal carotid and the posterior communicating arteries was noted in a patient with documented subarachnoid hemorrhage. This was initially thought to be infundibular dilatation. A craniotomy revealed an actual aneurysm, which was obliterated suc...

journal_title：Neurosurgery

authors： Yoshida M,Anegawa S,Moritaka K

更新日期：1981-12-01 00:00:00

abstract：:We have reviewed our experience with gangliogliomas treated in the post-computed tomography (CT) era at the Children's Hospital of Philadelphia. Of 234 newly histologically verified neoplasms seen at our institution since 1975, 10 (4.3%) were gangliogliomas of the cerebral hemispheres. The presenting complaint was sei...

journal_title：Neurosurgery

authors： Sutton LN,Packer RJ,Rorke LB,Bruce DA,Schut L

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Although transarterial regional hypothermia is an attractive alternative to general hypothermia, its efficacy and underlying mechanisms remain unclear. OBJECTIVE:To confirm transarterial regional hypothermia therapeutic effects on ischemia/reperfusion (I/R) injury and to elucidate the mechanisms responsible...

journal_title：Neurosurgery

authors： Kurisu K,Abumiya T,Nakamura H,Shimbo D,Shichinohe H,Nakayama N,Kazumata K,Shimizu H,Houkin K

更新日期：2016-07-01 00:00:00

abstract：:The authors present a case of pituitary apoplexy characterized by massive third ventricular hemorrhage. This rare complication, which caused total blindness in the patient, a 67-year-old man, was treated with transcranial decompression of the pituitary tumor and removal of a blood clot from the third ventricle. After ...

journal_title：Neurosurgery

authors： Taşdemiroğlu E,Zuccarello M,Tew JM Jr

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:Intraoperative aneurysmal rupture represents a potentially catastrophic event. We describe the use of an intravenous adenosine bolus to induce transient cardiac asystole to control a severe intraoperative aneurysmal rupture. This treatment resulted in a brief period of severe hypotension, which...

journal_title：Neurosurgery

authors： Nussbaum ES,Sebring LA,Ostanny I,Nelson WB

更新日期：2000-07-01 00:00:00