Abstract：
:A series of 2-(2-nitrobenzoyl)cyclohexane-1,3-dione analogues (1-9) were designed, synthesized, and evaluated for inhibition of 4-hydroxyphenylpyruvate dioxygenase (4-HPPD), a key enzyme involved in the catabolism of tyrosine which catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. The correlations between the results of enzyme inhibition, ferric chloride tests, and the conformational analysis suggested that the tight binding between triketone-type inhibitors and 4-HPPD is likely due to chelation of the enzyme-bound ferric iron with the enol tautomer of 1,3-diketone moiety of the triketones. The presence of a 2-carbonyl group in the triketone is an essential structural feature for potent 4-HPPD inhibition. Modification of the 3-carbonyl group of triketone moiety to other functionality will reduce the overall planarity and thus prevent keto-enol tautomerization, resulting in a decrease or lack of inhibition activity.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Wu CS,Huang JL,Sun YS,Yang DYdoi
10.1021/jm010568ykeywords:
subject
Has Abstractpub_date
2002-05-23 00:00:00pages
2222-8issue
11eissn
0022-2623issn
1520-4804pii
jm010568yjournal_volume
45pub_type
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