Exploring the syndrome of spatial unilateral neglect through an illusion of length.

Abstract:

:Both a neuropsychological syndrome (unilateral spatial neglect) and a visual illusion of length (the Brentano version of the Müller-Lyer illusion) bring about a misjudgement of the subjective centre of a horizontal line, with a unilateral shift. In experiment 1 we investigated, in patients with left unilateral neglect, illusory effects of horizontal length, with the aim of exploring the functional and neural basis of horizontal space perception, and the role of visual processing in shaping the patients' bisection performance. Fourteen right-brain-damaged patients with left spatial unilateral neglect, seven with and seven without left visual half-field deficits (assessed by confrontation, perimetry, and visual event-related potentials), entered this study. Two conditions of manual line bisection were assessed: setting the mid-point of a horizontal line, and of the shaft of the Brentano-Müller-Lyer illusion, with either a left- or a right-sided expansion. Both groups of patients set the subjective midpoint to the right of the objective centre of the line, consistent with the presence of left neglect. Patients with neglect and left hemianopia showed no illusory effects and a greater bisection error. The effects of the illusion, by contrast, were fully present in neglect patients without hemianopia, in both illusory conditions, adding to, or subtracting from, the rightward bisection bias. Anatomoclinical correlations revealed an association of damage to the occipital regions with the lack of illusory effects. Conversely, more anterior damage, sparing these regions, did not disrupt the illusion, revealing a dissociation between visual and spatial processing of extension. These findings suggest that processing of the Müller-Lyer illusion of length is likely to occur in the occipital cortex, at a retinotopic level of representation. In neglect patients with left homonymous hemianopia the visual deficit adds to the spatial bias, yielding a greater error in line bisection, but not in other visual exploratory tasks, such as cancellation, where the contribution of retinotopic frames is likely to be comparatively minor. Experiment 2 showed preserved illusory effects in patients with homonymous visual field defects without spatial unilateral neglect, suggesting that preserved spatial processing may compensate for unilateral visual field defects.

journal_name

Exp Brain Res

authors

Daini R,Angelelli P,Antonucci G,Cappa SF,Vallar G

doi

10.1007/s00221-002-1034-8

keywords:

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

224-37

issue

2

eissn

0014-4819

issn

1432-1106

journal_volume

144

pub_type

临床试验,杂志文章
  • Axial synergies during human upper trunk bending.

    abstract::Upper trunk bending movements were accompanied by opposite movements of the lower body segments. These axial kinematic synergies maintained equilibrium during the movement performance by stabilizing the center of gravity (CG), which shifted on average across all the subjects by 1 +/- 4 cm in the anteroposterior direct...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s002210050274

    authors: Alexandrov A,Frolov A,Massion J

    更新日期:1998-01-01 00:00:00

  • Convergence of sensory inputs in somatosensory cortex: interactions from separate afferent sources.

    abstract::Intracellular recording techniques were used to test for cross-modality and topographic convergence among inputs to area 3a of cerebral cortex. Recordings were made within the projection area of group I afferent fibers of the deep radial nerve in barbiturate-anesthetized cats. Epsps were evoked in 90% of neurons (81/9...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00236532

    authors: Kang R,Herman D,MacGillis M,Zarzecki P

    更新日期:1985-01-01 00:00:00

  • An investigation of the intrinsic circuitry of the motor cortex of the monkey using intra-cortical microstimulation.

    abstract::The motor cortex contains a distributed map of muscles, with a single muscle represented over a wide cortical area. We have searched for inter-connections between distant sites projecting to common muscles by delivering pairs of 20-microA single-pulse intracortical microstimuli (ICMS) to sites separated by 1.5-2 mm in...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050585

    authors: Baker SN,Olivier E,Lemon RN

    更新日期:1998-12-01 00:00:00

  • Community-dwelling adults with a history of falling report lower perceived postural stability during a foam eyes closed test than non-fallers.

    abstract::Perceived postural stability has been reported to decrease as sway area increases on firm surfaces. However, changes in perceived stability under increasingly challenging conditions (e.g., removal of sensory inputs) and the relationship with sway area are not well characterized. Moreover, whether perceived stability v...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-018-5458-1

    authors: Anson E,Studenski S,Sparto PJ,Agrawal Y

    更新日期:2019-03-01 00:00:00

  • A comparative study of the effects of morphine in the dorsal periaqueductal gray and nucleus accumbens of rats submitted to the elevated plus-maze test.

    abstract::We studied the effects of morphine injected either systemically or into the dorsal periaqueductal gray (DPAG) or nucleus accumbens (NA) using conventional and ethological analyses of behavior of rats submitted to the elevated plus-maze test with transparent walls. Intraperitoneal morphine (0.1 mg/kg and 0.3 mg/kg) inc...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050896

    authors: Anseloni VC,Coimbra NC,Morato S,Brandão ML

    更新日期:1999-11-01 00:00:00

  • Effects of delayed auditory and visual feedback on sequence production.

    abstract::This study represents the first systematic comparison of the relative contributions of auditory and visual feedback to sequence production. Participants learned an isochronous melody that they performed on a keyboard and attempted to perform this sequence at a prescribed rate while auditory and visual feedback were ma...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-012-3289-z

    authors: Kulpa JD,Pfordresher PQ

    更新日期:2013-01-01 00:00:00

  • Quantifying the effects of voluntary contraction and inter-stimulus interval on the human soleus H-reflex.

    abstract::The human soleus H-reflex is commonly tested as an indicator of the reflex excitability of the calf muscles with infrequent stimuli to a subject seated and at rest. However, the reflex varies widely with the level of voluntary contraction and with the time history of stimulation. We studied two aspects of this variati...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-007-0989-x

    authors: Stein RB,Estabrooks KL,McGie S,Roth MJ,Jones KE

    更新日期:2007-09-01 00:00:00

  • Derangement of body representation in complex regional pain syndrome: report of a case treated with mirror and prisms.

    abstract::Perhaps the most intriguing disorders of body representation are those that are not due to primary disease of brain tissue. Strange and sometimes painful phantom limb sensations can result from loss of afference to the brain; and Complex Regional Pain Syndrome (CRPS)-the subject of the current report-can follow limb t...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-2107-8

    authors: Bultitude JH,Rafal RD

    更新日期:2010-07-01 00:00:00

  • Body posture affects tactile discrimination and identification of fingers and hands.

    abstract::It is an unresolved question whether the posture of single fingers relative to each other is represented in the brain within an external frame of reference. In two experiments, we investigated postural influences on the processing of tactile stimuli at fingers and hands. Healthy subjects received two simultaneous tact...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-010-2396-y

    authors: Riemer M,Trojan J,Kleinböhl D,Hölzl R

    更新日期:2010-09-01 00:00:00

  • Changes in the bioenergetic state of rat hippocampus during 2.5 min of ischemia, and prevention of cell damage by cyclosporin A in hyperglycemic subjects.

    abstract::A recent study from this laboratory has shown that brief transient ischemia (2 min 30 s) in normo- and hyperglycemic rats leads to moderate neuronal necrosis in CA1 cells of the hippocampus, of equal density in the two groups. However, hyperglycemic animals failed to depolarize during the ischemia, nor did they show a...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/pl00005622

    authors: Folbergrová J,Li PA,Uchino H,Smith ML,Siesjö BK

    更新日期:1997-03-01 00:00:00

  • Filament size influences temperature changes and brain damage following middle cerebral artery occlusion in rats.

    abstract::Postischemic spontaneous hyperthermia as a complication of occlusion of the middle cerebral artery with an intraluminal filament has been observed by some authors, but many other reports do not discuss this factor. The possible reasons why some of the authors have not seen severe hyperthermia in their experiments incl...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-001-0909-4

    authors: Abrahám H,Somogyvári-Vigh A,Maderdrut JL,Vigh S,Arimura A

    更新日期:2002-01-01 00:00:00

  • Plasticity in the barrel cortex of the adult mouse: effects of peripheral deprivation on GAD-immunoreactivity.

    abstract::The whisker-to-barrel pathway of the adult mouse was used in a study on the effects of peripheral sensory deprivation on GAD-immunoreactivity in the somatosensory cortex. At varying periods of time after removal of a set of vibrissal follicles, mice were processed for immunohistochemistry using an antibody against GAD...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00247346

    authors: Welker E,Soriano E,Van der Loos H

    更新日期:1989-01-01 00:00:00

  • Effects of eye position on saccadic eye movements and on the neuronal responses to auditory and visual stimuli in cat superior colliculus.

    abstract::Many neurons in the deeper layers of the superior colliculus (SC) respond to multiple sensory inputs--visual, auditory, and somatic--as well as provide signals essential for saccadic eye movements to targets in different modalities. When the eyes and pinnae are in primary position, the neural map of auditory space is ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00231709

    authors: Peck CK,Baro JA,Warder SM

    更新日期:1995-01-01 00:00:00

  • Mono- and disynaptic excitatory inputs from the superior colliculus to vertical saccade-related neurons in the cat Forel's field H.

    abstract::Excitatory inputs to neurons in the Forel's field H (FFH) related to visually induced vertical saccades from the ipsilateral superior colliculus (SC) were investigated in chronically prepared alert cats. By stimulation of the deep or intermediate layer of the SC, upward augmenting neurons (ANs) and one long-lead downw...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00230857

    authors: Nakao S,Shiraishi Y,Li WB,Oikawa T

    更新日期:1990-01-01 00:00:00

  • Decreased functional connectivity of insula-based network in young adults with internet gaming disorder.

    abstract::The insula is a region that integrates interoception and drug urges, but little is known about its role in behavioral addiction such as internet addiction. We investigated insula-based functional connectivity in participants with internet gaming disorder (IGD) and healthy controls (HC) using resting-state functional M...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-016-4659-8

    authors: Zhang Y,Mei W,Zhang JX,Wu Q,Zhang W

    更新日期:2016-09-01 00:00:00

  • Local axonal trajectories in mouse barrel cortex.

    abstract::Quantitative studies were made of the distribution of labeled intracortical axons after focal injections of horseradish peroxidase (HRP) into mouse barrel cortex, in vitro. The pattern of labeled fibers was compared to that of labeled cell bodies with respect to the barrel map in layer IV. We analyzed 4 cortices with ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00231244

    authors: Bernardo KL,McCasland JS,Woolsey TA

    更新日期:1990-01-01 00:00:00

  • Effects of sensory deprivation upon a single cortical vibrissal column: a 2DG study.

    abstract::Effects of sensory deprivation upon ability of a vibrissa to activate a functional column in the barrel field of somatosensory cortex were examined with 2 deoxyglucose (2DG) autoradiography in the rat. After six weeks of whisker plucking started at birth, and one week of recovery, the cortical column activated by the ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00230950

    authors: Kossut M

    更新日期:1992-01-01 00:00:00

  • Perception of horizontal head and trunk rotation: modification of neck input following loss of vestibular function.

    abstract::Chronic loss of vestibular function modifies the role of neck afferents in human perception of self-motion. We characterized this change by comparing the self-motion perception of patients with chronic vestibular loss (Ps) to that of normal subjects (Ns). Stimuli consisted of sinusoidal horizontal rotations (0.025-0.4...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00227147

    authors: Schweigart G,Heimbrand S,Mergner T,Becker W

    更新日期:1993-01-01 00:00:00

  • Responses to anterior and posterior perturbations in Parkinson's disease with early postural instability: role of axial and limb rigidity.

    abstract::We studied 12 patients with Parkinson's disease (PD): 6 with postural instability (Hoehn and Yahr Stage 3) and 6 without (Stage 2 or 2.5), using a quantitative test based on the clinical pull test. Their findings were compared with those for 12 healthy controls. The patients on their usual medications were pulled eith...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-019-05553-8

    authors: Colebatch JG,Govender S

    更新日期:2019-07-01 00:00:00

  • Initial nociceptive sensitization in carrageenin-induced rat paw inflammation is dependent on amine autacoid mechanisms: electrophysiological and behavioural evidence obtained with a quaternary antihistamine, thiazinamium.

    abstract::We have studied the ability of a quaternary antihistamine, thiazinamium, to inhibit the nociceptive sensitization that occurs early, during the first hour, following intraplantar injection of the polysaccharide carrageenin in the rat. Parallel studies were performed with an electrophysiological model (changes in respo...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00236307

    authors: Neil A,Benoist JM,Kayser V,Guilbaud G

    更新日期:1987-01-01 00:00:00

  • Contribution of tactile feedback from the hand to the perception of force.

    abstract::A force-matching task was used to study the influence of constraining tactile information from the hand on the perception of forces generated with the index finger flexors, the palmar prehensile grasp and with the elbow flexors. Subjects generated the same reference forces (2-10 N) with each muscle group and matched t...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-005-0259-8

    authors: Jones LA,Piateski E

    更新日期:2006-01-01 00:00:00

  • Slowing of dexterous manipulation in old age: force and kinematic findings from the 'nut-and-rod' task.

    abstract::The task of sliding a nut from a rod has been used to study manual slowing in old age (Smith et al. in Neurology 53:1458-1461, 1999; Neurobiol Aging 26:883-890, 2005). In this experiment, we sought to determine if the age-related slowing in this task occurs with losses of motor precision, as indicated by the forces ex...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-2030-z

    authors: Cole KJ,Cook KM,Hynes SM,Darling WG

    更新日期:2010-03-01 00:00:00

  • Effector-dependent acquisition of novel typing sequences.

    abstract::In an earlier report we found that when pairs of letters were physically transposed on the keyboard and typists were required to type letters in their new location, the disruptions in typing were reduced when the transpositions involved mirror movements of homologous fingers of the two hands compared with transpositio...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210000592

    authors: Parasher R,Roy S,Gordon AM

    更新日期:2001-02-01 00:00:00

  • Direct visualization of death of neurones projecting to specific targets in the developing rat brain.

    abstract::The fluorescent dye diamidino yellow was injected into parts of the developing visual and auditory systems in the rat. The dye was retrogradely transported by projecting neurones and was found to stain pyknotic profiles within the labelled cell populations. It is thus possible to visualize directly the death of neuron...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00228865

    authors: Harvey AR,Robertson D,Cole KS

    更新日期:1990-01-01 00:00:00

  • Adaptation and habituation of the vestibulo-ocular reflex in intact and inferior olive-lesioned rats.

    abstract::The gain of the vestibulo-ocular reflex (VOR) of intact pigmented rats was adaptively modified by training protocols that created a visual-vestibular conflict. For training, head restrained animals were oscillated on a turntable in front of an optokinetic pattern projected onto a cylindrical wall. The optokinetic patt...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00230530

    authors: Tempia F,Dieringer N,Strata P

    更新日期:1991-01-01 00:00:00

  • Intermanual transfer of proximal and distal motor engrams in humans.

    abstract::We studied intermanual motor transfer for right-to-left or left-to-right direction of transfer between either proximal or distal upper extremity muscle groups. The influence of previously acquired motor engrams (original learning, OL) on learning efficiency of the contralateral side (transfer learning, TL) was examine...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00228105

    authors: Thut G,Cook ND,Regard M,Leenders KL,Halsband U,Landis T

    更新日期:1996-03-01 00:00:00

  • Initiation and cancellation of the human heave linear vestibulo-ocular reflex after unilateral vestibular deafferentation.

    abstract::The effect of unilateral vestibular deafferentation (UVD) on the linear vestibulo-ocular reflex (LVOR) was studied in 11 humans an average of 52 months following surgical UVD. Controls consisted of seven healthy age-matched subjects. The LVOR was evoked by directionally random, transient whole body interaural (heave) ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-004-2089-5

    authors: Crane BT,Tian JR,Ishiyama A,Demer JL

    更新日期:2005-03-01 00:00:00

  • The frontal eye fields target multisensory neurons in cat superior colliculus.

    abstract::While sensory corticotectal connections have received considerable attention, relatively little is known about the nature of superior colliculus neurons that receive input from the cortical frontal eye fields. The present experiments used microstimulation of indwelling electrodes in the frontal eye fields and single-u...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050869

    authors: Meredith MA

    更新日期:1999-10-01 00:00:00

  • From the neuromatrix to the pain matrix (and back).

    abstract::Pain is a conscious experience, crucial for survival. To investigate the neural basis of pain perception in humans, a large number of investigators apply noxious stimuli to the body of volunteers while sampling brain activity using different functional neuroimaging techniques. These responses have been shown to origin...

    journal_title:Experimental brain research

    pub_type: 杂志文章,评审

    doi:10.1007/s00221-010-2340-1

    authors: Iannetti GD,Mouraux A

    更新日期:2010-08-01 00:00:00

  • A diverse pattern of the spike threshold changes in feline gastrocnemius-soleus motoneurons during stretch reflex activation.

    abstract::The aim of the study was to define the spike threshold changes in motoneurons during naturally evoked activation. Spike activity was evoked in the gastrocnemius-soleus motoneurons of decerebrate cats by controlled stretches of the homonymous muscles. The spike thresholds were defined by using the first derivative of t...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-010-2285-4

    authors: Kostyukov AI,Lytvynenko SV,Bulgakova NV,Gorkovenko AV

    更新日期:2010-06-01 00:00:00