The effects of ACTH and adrenocorticosteroids on seizure susceptibility in 15-day-old male rats.


:Infantile spasms are generalized convulsive seizures seen in the first year of life. They respond poorly to conventional anticonvulsants, but are often controlled by adrenocorticotropic hormone (ACTH) therapy. Other childhood seizures are also responsive to ACTH. The present study tested the effects of ACTH and related adrenocorticosteroids in prepubertal, 15-day-old rats. Compounds were tested against minimal (scMET) and maximal (MMT) pentylenetetrazol seizures, maximal electroconvulsive shock (MES) seizures, and hippocampal kindled seizures. ACTH had no significant anticonvulsant effects against any type of seizure. Several of the adrenocorticoid hormones, however, had strong anticonvulsant effects. Deoxycorticosterone (DOC) and progesterone (P4) both significantly suppressed scMET, MMT, and MES seizures 15 min after s.c. injection. DOC and P4 also shortened hippocampal discharge duration in the kindling model, and DOC, but not P4, suppressed the kindled convulsion. Aldosterone and corticosterone were effective against scMET seizures, and aldosterone was effective against MMT seizures. Dexamethasone and dihydroepiandrosterone had no anticonvulsant activity. These findings indicate that the adrenal steroid precursors, DOC and P4, have a broad spectrum of anticonvulsant activity in animal seizure models. They may play a role in mediating the anticonvulsant effects of ACTH in human infants.


Exp Neurol


Experimental neurology


Edwards HE,Vimal S,Burnham WM





Has Abstract


2002-05-01 00:00:00














  • Neurogenesis in postnatal mouse dorsal root ganglia.

    abstract::Neurogenesis continues in various regions of the central nervous system (CNS) throughout life. As the mitogen basic fibroblast growth factor (bFGF) can proliferate neuronal precursors of CNS neurons in culture, and is also upregulated within adult dorsal root ganglia following axotomy, it is possible that the postnata...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Namaka MP,Sawchuk M,MacDonald SC,Jordan LM,Hochman S

    更新日期:2001-11-01 00:00:00

  • Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors.

    abstract::Estrogen has been suggested to be pro-epileptic by reducing GABA synthesis, resulting in increased spine density and a decreased threshold for seizures in the hippocampus, which, once they occur, are characterized by a dramatic spine loss in the affected brain areas. As considerable amounts of estradiol are synthesize...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Zhou L,Lehan N,Wehrenberg U,Disteldorf E,von Lossow R,Mares U,Jarry H,Rune GM

    更新日期:2007-01-01 00:00:00

  • The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury.

    abstract::Substantial residual neurological function may persist after spinal cord injury (SCI) with survival of as few as 5-10% of the original number of axons. A detailed understanding of the relationships among the severity of injury, the number and origin of surviving axons at the injury site, and the extent of neurological...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Fehlings MG,Tator CH

    更新日期:1995-04-01 00:00:00

  • Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture.

    abstract::Peripheral neuropathy (PN) is a debilitating and dose-limiting side effect of treatment with the chemotherapeutic agent, paclitaxel. Understanding the effects of paclitaxel on sensory neuronal function and the signaling pathways which mediate these paclitaxel-induced changes in function are critical for the developmen...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Pittman SK,Gracias NG,Vasko MR,Fehrenbacher JC

    更新日期:2014-03-01 00:00:00

  • Acute intermittent hypoxia boosts spinal plasticity in humans with tetraplegia.

    abstract::Paired corticospinal-motoneuronal stimulation (PCMS) elicits spinal synaptic plasticity in humans with chronic incomplete cervical spinal cord injury (SCI). Here, we examined whether PCMS-induced plasticity could be potentiated by acute intermittent hypoxia (AIH), a treatment also known to induce spinal synaptic plast...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Christiansen L,Chen B,Lei Y,Urbin MA,Richardson MSA,Oudega M,Sandhu M,Rymer WZ,Trumbower RD,Mitchell GS,Perez MA

    更新日期:2021-01-01 00:00:00

  • Defining the mechanisms that underlie cortical hyperexcitability in amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis [ALS] is a rapidly progressive neurodegenerative disorder of motor neurons, heralded by the development of cortical hyperexcitability. Reduction of short interval intracortical inhibition [SICI] in ALS, a feature linked to the development of cortical hyperexcitability, may be mediated by ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Vucic S,Cheah BC,Kiernan MC

    更新日期:2009-11-01 00:00:00

  • Enhancing KCC2 activity decreases hyperreflexia and spasticity after chronic spinal cord injury.

    abstract::After spinal cord injury (SCI), the majority of individuals develop spasticity, a debilitating condition involving involuntary movements, co-contraction of antagonistic muscles, and hyperreflexia. By acting on GABAergic and Ca2+-dependent signaling, current anti-spastic medications lead to serious side effects, includ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Bilchak JN,Yeakle K,Caron G,Malloy D,Côté MP

    更新日期:2021-01-13 00:00:00

  • Exposure to prenatal carbon monoxide and postnatal hyperthermia: short and long-term effects on neurochemicals and neuroglia in the developing brain.

    abstract::The effects of prenatal exposure to carbon monoxide (CO), a major component of cigarette smoke, was studied alone or in combination with postnatal hyperthermia, on the structural and neurochemical development of the postnatal brain at 1 and 8 weeks. Pregnant guinea pigs (n = 11) were exposed to 200 p.p.m CO for 10 h/d...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Tolcos M,Mallard C,McGregor H,Walker D,Rees S

    更新日期:2000-04-01 00:00:00

  • The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS.

    abstract::The ability of insulin like growth factor 1 (IGF-1) to prevent the pathophysiology associated with amyotrophic lateral sclerosis (ALS) is currently being explored with animal models and in clinical trials with patients. Several studies have reported positive effects of IGF-1 in reducing motor neuron death, delaying th...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Messi ML,Clark HM,Prevette DM,Oppenheim RW,Delbono O

    更新日期:2007-09-01 00:00:00

  • Development of tolerance to the anticonvulsant effect of diazepam in amygdala-kindled rats.

    abstract::The anticonvulsant long-term efficacy of diazepam was studied in amygdala-kindled rats. The drug was administered three times daily at doses of 5 mg/kg i.p. for 2 weeks in fully kindled animals. The severity of the kindled seizures was markedly reduced throughout the period of treatment, while tolerance developed to t...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Löscher W,Schwark WS

    更新日期:1985-11-01 00:00:00

  • Calpain inhibition attenuates intracellular changes in muscle cells in response to extracellular inflammatory stimulation.

    abstract::Idiopathic inflammatory myopathies (IIMs), comprising of polymyositis, dermatomyositis, and inclusion-body myositis, are characterized by muscle weakness and various types of inflammatory changes in muscle cells. They also show non-inflammatory changes, including perifascicular atrophy, mitochondrial changes, and amyl...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Nozaki K,Das A,Ray SK,Banik NL

    更新日期:2010-10-01 00:00:00

  • Postural development in rats.

    abstract::Mammals adopt a limited number of postures during their day-to-day activities. These stereotyped skeletal configurations are functionally adequate and limit the number of degrees of freedom to be controlled by the central nervous system. The temporal pattern of emergence of these configurations in altricial mammals is...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Lelard T,Jamon M,Gasc JP,Vidal PP

    更新日期:2006-11-01 00:00:00

  • Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord.

    abstract::We examined the myelin repair potential of transplanted neural precursor cells derived from the adult human brain from tissue removed during surgery. Sections of removed brain indicated that nestin-positive cells were found predominantly in the subventricular zone around the anterior horns of the lateral ventricle and...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Akiyama Y,Honmou O,Kato T,Uede T,Hashi K,Kocsis JD

    更新日期:2001-01-01 00:00:00

  • Kindling of audiogenic seizures in Wistar rats: an EEG study.

    abstract::The EEG of 20 Wistar rats inbred for audiogenic seizures was recorded during 40 daily auditory stimuli 90 s long. The first stimuli provoked wild running, with no cortical EEG abnormality, and then a tonic phase with a characteristic EEG of a brief flat trace 2 to 3 s long followed by low-amplitude regular activity, 1...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Marescaux C,Vergnes M,Kiesmann M,Depaulis A,Micheletti G,Warter JM

    更新日期:1987-07-01 00:00:00

  • Tooth pulp-evoked jaw-opening reflex in the cat: evidence for central facilitation induced by noxious discharge in the intradental nerve fibers.

    abstract::The tooth pulp-evoked jaw-opening reflex was studied in the barbiturate-anesthetized cat. At liminal intensity of the stimulus, a stable short-latency response was obtained in the digastricus and in the tongue. At a higher stimulus intensity, there occasionally appeared to be a prolonged discharge of variable duration...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Pertovaara A,Huopaniemi T,Aukee K

    更新日期:1986-04-01 00:00:00

  • Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat.

    abstract::Dementia and parkinsonism are late-onset symptoms associated with repetitive head injury, as documented in multiple contact-sport athletes. Clinical symptomatology is the likely phenotype of chronic degeneration and circuit disruption in the substantia nigra (SN). To investigate the initiating neuropathology, we hypot...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: van Bregt DR,Thomas TC,Hinzman JM,Cao T,Liu M,Bing G,Gerhardt GA,Pauly JR,Lifshitz J

    更新日期:2012-03-01 00:00:00

  • Embryonic substantia nigra grafts innervate embryonic striatal co-grafts in preference to mature host striatum.

    abstract::Embryonic substantia nigra grafts partially reinnervate the dopamine-denervated corpus striatum when implanted adjacent to that structure. This reinnervation is generally limited to a small portion of the denervated striatum and does not completely compensate for the behavioral effects of a 6-hydroxydopamine lesion of...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: de Beaurepaire R,Freed WJ

    更新日期:1987-02-01 00:00:00

  • Minocycline delays disease onset and mortality in reovirus encephalitis.

    abstract::Minocycline is neuroprotective in many experimental models of neurodegenerative diseases and central nervous system (CNS) injury but has not previously been tested in a model of viral encephalitis. Experimental infection of neonatal mice with neurotropic reoviruses is a classic model for studying the pathogenesis of v...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Richardson-Burns SM,Tyler KL

    更新日期:2005-04-01 00:00:00

  • In vivo changes of catecholamines in hemiparkinsonian monkeys measured by microdialysis.

    abstract::In monkeys, unilateral intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces a useful model of hemiparkinsonism. To evaluate MPTP-induced neurochemical changes in vivo, brain microdialysis was employed to measure extracellular levels of dopamine and its metabolites in the neostriatum of...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Skirboll S,Wang J,Mefford I,Hsiao J,Bankiewicz KS

    更新日期:1990-11-01 00:00:00

  • Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizures.

    abstract::Granule cell (GC) neurogenesis increases following seizures, and some newborn GCs develop in abnormal locations within the hilus. These ectopic GCs (EGCs) display robust spontaneous and evoked excitatory activity. However, the pattern of afferent input they receive has not been fully defined. This study used electron ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Pierce JP,Melton J,Punsoni M,McCloskey DP,Scharfman HE

    更新日期:2005-12-01 00:00:00

  • Wld(S) mice are protected against the Parkinsonian mimetic MPTP.

    abstract::The progressive loss of the nigrostriatal pathway is a distinguishing feature of Parkinson's disease. Because terminal field loss appears to precede cell body loss, we tested whether the mouse mutant Wld(S), which delays axonal degeneration in a variety of disorders, would ameliorate nigrostriatal degeneration followi...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Hasbani DM,O'Malley KL

    更新日期:2006-11-01 00:00:00

  • Reciprocal pre- and postsynaptic actions of cocaine at a central noradrenergic synapse.

    abstract::Single-unit microelectrode studies were conducted to test the effects of systemic cocaine HCl on spontaneously firing single noradrenergic locus ceruleus (presynaptic) and cerebellar Purkinje (postsynaptic) neurons in rats in vivo. The spontaneous neuronal activity of all locus ceruleus neurons was inhibited by cocain...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Pitts DK,Marwah J

    更新日期:1987-12-01 00:00:00

  • The neurotoxicity of amphetamines: bridging drugs of abuse and neurodegenerative disorders.

    abstract::Amphetamine derivatives are the most commonly abused drugs. These compounds have been known for many years to induce neurotoxicity. However, recent findings have highlighted novel alterations produced by amphetamines in the central nervous system consisting of neuronal inclusions and the involvement of proteins belong...

    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


    authors: Iacovelli L,Fulceri F,De Blasi A,Nicoletti F,Ruggieri S,Fornai F

    更新日期:2006-09-01 00:00:00

  • GDNF gene delivery via the p75(NTR) receptor rescues injured motor neurons.

    abstract::The retrograde axonal transport mechanism of motor neurons has been exploited to deliver the gene encoding Glial cell line-derived neurotrophic factor (GDNF) into the central nervous system to provide trophic support following injury. A nonviral gene delivery system, consisting of a monoclonal antibody (MC192) that bi...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Barati S,Hurtado PR,Zhang SH,Tinsley R,Ferguson IA,Rush RA

    更新日期:2006-11-01 00:00:00

  • Differential expression of tenascin-C, tenascin-R, tenascin/J1, and tenascin-X in spinal cord scar tissue and in the olfactory system.

    abstract::The members of the tenascin family are involved in a number of developmental processes, mainly by their ability to regulate cell adhesion. We have here studied the distribution of mRNAs for tenascin-X, -C, and -R and the closely related molecule tenascin/J1 in the olfactory system and spinal cord. The olfactory bulb a...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Deckner M,Lindholm T,Cullheim S,Risling M

    更新日期:2000-12-01 00:00:00

  • Electromyogram coactivation patterns of the elbow antagonist muscles during slow isokinetic movement.

    abstract::Electromyograms from the flexor and extensor muscles of normal human elbows were simultaneously recorded during maximal-effort isokinetic movement at 15 degrees/s over the joint's full range of motion. The antagonist electromyogram was normalized with respect to its electromyogram when acting as agonist at maximal eff...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Solomonow M,Baratta R,Zhou BH,D'Ambrosia R

    更新日期:1988-06-01 00:00:00

  • A comparison of thyroxine- and polyamine-mediated enhancement of rat facial nerve regeneration.

    abstract::Thyroid hormones and spermidine, a motor neuron trophic polyamine (PA), have been shown to enhance peripheral motor nerve regeneration; however, the mechanism by which these treatment modalities exert their effect is unknown. Similarities in treatment outcome suggest that these molecules may be working via a common me...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Oble DA,Burton L,Maxwell K,Hassard T,Nathaniel EJ

    更新日期:2004-09-01 00:00:00

  • Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker's syndrome.

    abstract::A host protein encoded by the gene specifying the scrapie amyloid precursor affects pathogenesis of the transmissible spongiform encephalopathies: Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker's syndrome (GSS), and kuru in man, and scrapie in animals. We found a mutation in this gene of two patients ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Goldgaber D,Goldfarb LG,Brown P,Asher DM,Brown WT,Lin S,Teener JW,Feinstone SM,Rubenstein R,Kascsak RJ

    更新日期:1989-11-01 00:00:00

  • In vivo microdialysis studies on somatodendritic dopamine release in the rat substantia nigra: effects of unilateral 6-OHDA lesions and GDNF.

    abstract::Dopamine (DA) release and metabolism within the substantia nigra (SN) were studied in normal rats, rats with unilateral 6-hydroxydopamine (6-OHDA) lesions, and 6-OHDA-lesioned rats treated with glial cells line-derived neurotrophic factor (GDNF). Animals with > 99% DA depletions, as determined by apomorphine-induced c...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Hoffman AF,van Horne CG,Eken S,Hoffer BJ,Gerhardt GA

    更新日期:1997-09-01 00:00:00

  • Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin.

    abstract::Twenty-one-day-old Wistar rats were fed a diet containing 0.6% cuprizone for 2 weeks. Studies carried out after withdrawal of cuprizone showed histological evidences of marked demyelination in the corpus callosum. Biochemical studies of isolated myelin showed a marked decrease in myelin proteins, phospholipids, and ga...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Adamo AM,Paez PM,Escobar Cabrera OE,Wolfson M,Franco PG,Pasquini JM,Soto EF

    更新日期:2006-04-01 00:00:00