Abstract:
:A possible diagnostic role of procalcitonin (PCT) as a marker for ventilator associated pneumonia (VAP) in patients with an already triggered acute phase response after successful cardiopulmonary resuscitation (CPR) was investigated. In 28 patients with return of spontaneous circulation (ROSC) after out of hospital CPR, measurements of PCT, C-reactive protein (CrP), white blood cell count (WBC) and body temperature were compared with the clinical course of the patients. In this setting, PCT was the only marker to differentiate between patients with and without VAP (median value on day 1, 6.0 vs. 0.5 ng/ml; P<0.001). Using a cut off value of 1 ng/ml during the first 7 days after ROSC PCT had a sensitivity of 100% and a specificity of 75% to indicate VAP. PCT was elevated a median of 2 days earlier than the clinical diagnosis of VAP. Elevations in PCT can, therefore, indicate bacterial complications in cardiac arrest patients with a non-infectious acute phase response.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Oppert M,Reinicke A,Müller C,Barckow D,Frei U,Eckardt KUdoi
10.1016/s0300-9572(02)00008-4keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
167-70issue
2eissn
0300-9572issn
1873-1570pii
S0300957202000084journal_volume
53pub_type
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