Regulation of ROMK channels by protein tyrosine kinase and tyrosine phosphatase.

Abstract:

:Renal outer medulla K (ROMK) channels play an important role in K recycling in the thick ascending limb and in K secretion in the cortical collecting duct. ROMK1, a member of the ROMK family, has been shown to be a substrate for protein tyrosine kinase (PTK). The tyrosine phosphorylation of ROMK channels increases with low dietary K intake and decreases with high dietary K intake. Moreover, the stimulation of tyrosine phosphorylation of ROMK1 channels decreases the number of K channels by facilitating endocytosis. In contrast, the stimulation of tyrosine dephosphorylation increases the number of ROMK1 channels in the cell membrane by enhancing membrane insertion. PTK and tyrosine phosphatase-induced regulation of ROMK1 channels play a key role in mediating the effect of the dietary K intake on renal K secretion.

journal_name

Trends Cardiovasc Med

authors

Wang WH,Lin DH,Sterling H

doi

10.1016/s1050-1738(02)00155-x

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

138-42

issue

3

eissn

1050-1738

issn

1873-2615

pii

S105017380200155X

journal_volume

12

pub_type

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