Regulation of ROMK channels by protein tyrosine kinase and tyrosine phosphatase.


:Renal outer medulla K (ROMK) channels play an important role in K recycling in the thick ascending limb and in K secretion in the cortical collecting duct. ROMK1, a member of the ROMK family, has been shown to be a substrate for protein tyrosine kinase (PTK). The tyrosine phosphorylation of ROMK channels increases with low dietary K intake and decreases with high dietary K intake. Moreover, the stimulation of tyrosine phosphorylation of ROMK1 channels decreases the number of K channels by facilitating endocytosis. In contrast, the stimulation of tyrosine dephosphorylation increases the number of ROMK1 channels in the cell membrane by enhancing membrane insertion. PTK and tyrosine phosphatase-induced regulation of ROMK1 channels play a key role in mediating the effect of the dietary K intake on renal K secretion.


Trends Cardiovasc Med


Wang WH,Lin DH,Sterling H





Has Abstract


2002-04-01 00:00:00














  • TGF-beta in the cardiovascular system: molecular mechanisms of a context-specific growth factor.

    abstract::Transforming growth factor beta-1 is the prototypical member of a class of growth factors whose actions have been strongly implicated in a number of pathophysiologic processes including chronic vascular diseases such as atherosclerosis and hypertension. One of the hall-marks of this class of growth factors is the dive...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Topper JN

    更新日期:2000-04-01 00:00:00

  • Intracellular assembly of VLDL: two major steps in separate cell compartments.

    abstract::The assembly of very low-density lipoproteins (VLDL) occurs in two major steps. The first step is the co-and post-translational lipidation of apoB, forming pre-VLDL in the rough endoplasmic reticulum. The microsomal triglyceride transfer protein catalyzes this step. In the second step pre-VLDL is converted to bona fid...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章


    authors: Olofsson SO,Stillemark-Billton P,Asp L

    更新日期:2000-11-01 00:00:00

  • GPCR biased ligands as novel heart failure therapeutics.

    abstract::G protein-coupled receptors have been successfully targeted by numerous therapeutics including drugs that have transformed the management of cardiovascular disease. However, many GPCRs, when activated or blocked by drugs, elicit both beneficial and adverse pharmacology. Recent work has demonstrated that in some cases,...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Violin JD,Soergel DG,Boerrigter G,Burnett JC Jr,Lark MW

    更新日期:2013-10-01 00:00:00

  • Use of human tissue specimens obtained by directional atherectomy to study restenosis.

    abstract::Directional atherectomy has provided the opportunity to study the pathology of restenosis in human tissue specimens from live patients. The restenosis lesion is characterized by two distinctive features: a focus of hypercellularity, comprised of cells with phenotypic features of proliferative vascular smooth muscle ce...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章


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  • Characterization and culture of human embryonic stem cells.

    abstract::Human embryonic stem (ES) cells are cultured cell lines derived from the inner cell mass of the blastocyst that can be grown indefinitely in their undifferentiated state, yet also are capable of differentiating into all cells of the adult body as well as extraembryonic tissue. Detailed investigation of the properties ...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章


    authors: Laslett AL,Filipczyk AA,Pera MF

    更新日期:2003-10-01 00:00:00

  • Regulation of cardiac development by receptor tyrosine kinases.

    abstract::The development of a functional heart depends on the coordinated growth, differentiation, migration, and apoptosis of cell populations of diverse embryological origins. These processes are regulated in part by soluble polypeptide growth factors that exert their effects via binding to cell surface receptors with intrin...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章


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  • Cardiovascular manifestations of myotonic dystrophy.

    abstract::Patients with myotonic dystrophy, the most common neuromuscular dystrophy in adults, have a high prevalence of arrhythmic complications with increased cardiovascular mortality and high risk for sudden death. Sudden death prevention is central and relies on annual follow-up and prophylactic permanent pacing in patients...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Wahbi K,Furling D

    更新日期:2020-05-01 00:00:00

  • Of cardiovascular illness and diversity of biological response.

    abstract::Noise in gene expression (stochastic variation in the composition of the transcriptome in response to stimuli) may play an important role in maintaining robustness and flexibility, which ensure the stability of normal physiology and provide adaptability to environmental changes for the living system. Broad-based techn...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Goldschmidt-Clermont PJ,Dong C,West M,Seo DM

    更新日期:2008-07-01 00:00:00

  • The mouse model for atherosclerosis.

    abstract::The mouse model provides unique tools for studies of the complex environmental and genetic interactions underlying atherosclerosis. In particular, a great variety of inbred strains exhibit variations affecting lipoprotein metabolism, diabetes, obesity, immune regulation, and other processes relevant to the disease. Th...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章


    authors: Lusis AJ

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  • Is there a role for cardiomyocyte toll-like receptor 4 in endotoxemia?

    abstract::Lipopolysaccharide (LPS) is thought to be an important molecule in myocardial depression in sepsis. Toll-like receptor 4 (TLR4), the lipopolysaccharide receptor, is known to underlie these responses. Because TLR4 is expressed on both cardiac myocytes and immune cells, it is unclear as to which cell type is responsible...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Tavener SA,Kubes P

    更新日期:2005-07-01 00:00:00

  • Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.

    abstract::In vascular disease states such as atherosclerosis and diabetes, endothelial nitric oxide (NO) bioactivity is reduced and oxidative stress is increased, resulting in endothelial dysfunction. Recent studies suggest that changes in the activity and regulation of endothelial NO synthase by its cofactor tetrahydrobiopteri...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Channon KM

    更新日期:2004-11-01 00:00:00

  • Transcriptional pathways direct cardiac development and regeneration.

    abstract::Elegant studies using gene disruption strategies have defined a set of genes that are essential for normal cardiac development. Although these studies have provided a framework for the molecular regulation of cardiac morphogenesis, the genetic program of the cardiac progenitors has been incompletely defined. We used a...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Latif S,Masino A,Garry DJ

    更新日期:2006-10-01 00:00:00

  • Another view of personalized medicine: optimizing stent selection on the basis of predicted benefit in percutaneous coronary intervention.

    abstract::Drug-eluting stents (DES) decrease the risk of restenosis compared to bare metal stents (BMS) for percutaneous coronary intervention (PCI). However, their use requires patients to take prolonged dual antiplatelet therapy that increases bleeding risk and without which, patients have an increased risk of developing sten...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Wimmer NJ,Yeh RW

    更新日期:2012-01-01 00:00:00

  • Genomic analysis of circulating cells: a window into atherosclerosis.

    abstract::Translational studies using genomic techniques in cardiovascular diseases are still in their infancy. Access to disease-associated cardiovascular tissues from patients has been a major impediment to progress in contrast to the diagnostic advances made by oncologists using gene expression on readily available tumor sam...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Kang JG,Patino WD,Matoba S,Hwang PM

    更新日期:2006-07-01 00:00:00

  • Gene transfer and cardiovascular disease.

    abstract::Through the introduction of foreign DNA into somatic cells, the aim of gene therapy is to correct or prevent disorders caused by the absence or malfunction of genes within a diseased individual. Expression of recombinant genes at specific sites within the vasculature can provide insights into vascular biology and pote...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章


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  • Glycogen synthase kinase-3beta -- actively inhibiting hypertrophy.

    abstract::A number of signaling pathways are involved in the regulation of cardiac hypertrophy and remodeling. One that serves as an integrator of upstream inputs, and as a transducer to downstream effectors, is the protein kinase, glycogen synthase kinase-3beta. In this work we review the role of this putative "nodal point" in...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Kerkelä R,Woulfe K,Force T

    更新日期:2007-04-01 00:00:00

  • Current concepts in restenosis following balloon angioplasty.

    abstract::Although ballon angioplasty has become a common intervention in vascular disease, long-term success is limited by restenosis. Restenosis is the consequence of a series of interactions between lymphocytes, platelets, smooth muscle cells, macrophages and endothelial cells, as well as their different cellular products. W...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章


    authors: Mattsson E,Clowes AW

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  • LRP and PDGF signaling: a pathway to atherosclerosis.

    abstract::The low-density lipoprotein (LDL) receptor-related protein (LRP) is a member of the LDL receptor family. In addition to its role in endocytosis and uptake of multiple ligands, it is now apparent that LRP, like some other members of the family, is also involved in signal transduction. Through LRP, both endocytosis and ...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Boucher P,Gotthardt M

    更新日期:2004-02-01 00:00:00

  • Zebrafish model: worth considering in defining tumor angiogenesis.

    abstract::The process of angiogenesis is essential for tumor progression and metastasis; however, antiangiogenesis therapy-induced hypoxia and inflammation are perhaps the driving force for tumor escape and metastasis formation, thereby compromising its efficacy. This warrants the complete understanding of the molecular and cel...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Moshal KS,Ferri-Lagneau KF,Leung T

    更新日期:2010-05-01 00:00:00

  • Human atrial fibrillation: insights from computational electrophysiological models.

    abstract::Computational electrophysiology has proven useful to investigate the mechanisms of cardiac arrhythmias at various spatial scales, from isolated myocytes to the whole heart. This article reviews how mathematical modeling has aided our understanding of human atrial myocyte electrophysiology to study the contribution of ...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Bers DM,Grandi E

    更新日期:2011-07-01 00:00:00

  • Fibronectin-fibrin cross-linking: a regulator of cell behavior.

    abstract::At sites of tissue injury or inflammation, extravasation of plasma proteins leads to the formation of a complex fibrillar matrix composed primarily of fibrin and plasma fibronectin (pFN). This protein meshwork serves not only to reestablish the integrity of the vascular system but also to provide a scaffold for cell m...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章


    authors: Corbett SA,Schwarzbauer JE

    更新日期:1998-11-01 00:00:00

  • Tissue-engineered vascular grafts for congenital cardiac disease: Clinical experience and current status.

    abstract::Congenital heart disease is a leading cause of death in the newborn period, and man-made grafts currently used for reconstruction are associated with multiple complications. Tissue engineering can provide an alternative source of vascular tissue in congenital cardiac surgery. Clinical trials have been successful overa...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Drews JD,Miyachi H,Shinoka T

    更新日期:2017-11-01 00:00:00

  • Ryanodine receptor phosphorylation, calcium/calmodulin-dependent protein kinase II, and life-threatening ventricular arrhythmias.

    abstract::Ryanodine receptor (RyR2) dysfunction, which may result from a variety of mechanisms, has been implicated in the pathogenesis of cardiac arrhythmias and heart failure. In this review, we discuss the important role of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the regulation of RyR2-mediated Ca(2+) relea...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: McCauley MD,Wehrens XH

    更新日期:2011-02-01 00:00:00

  • Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation.

    abstract::Lysophosphatidic acid and sphingosine 1-phosphate are bioactive lipid mediators with potent effects on cardiovascular development and vascular function. New studies define dynamic mechanisms that maintain physiologically relevant levels of both lipids in the blood. We review the mechanisms controlling the production, ...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Morris AJ,Selim S,Salous A,Smyth SS

    更新日期:2009-05-01 00:00:00

  • Functional disorders in non-culprit coronary arteries and their implications in patients with acute myocardial infarction.

    abstract::Approximately 30-50% of patients with ST-segment elevation acute myocardial infarction have multivessel disease. The physiology of the non-culprit artery (NCA) is complex and represents a challenge to physicians as, while these plaques are presumably stable, clinical data show that they frequently lead to major advers...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Díez-Delhoyo F,Gutiérrez-Ibañes E,Fernández-Avilés F

    更新日期:2020-08-01 00:00:00

  • Genomic and proteomic profiles of heart disease.

    abstract::Genomics and proteomics are becoming powerful tools for profiling diseased states. The human genome is estimated to encode 30,000 to 40,000 genes, generating more than 100,000 functionally distinct proteins. Microarray data are available for multiple models of heart disease as well as for diseased and failing human he...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Prentice H,Webster KA

    更新日期:2004-10-01 00:00:00

  • Two-way interactions between inflammation and coagulation.

    abstract::Activation of inflammatory and coagulation pathways is important in the pathogenesis of vascular disease. There is ample evidence that extensive cross-talk between these two systems exists, whereby inflammation not only leads to activation of coagulation, but coagulation also markedly affects inflammatory activity. Th...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Levi M,van der Poll T

    更新日期:2005-10-01 00:00:00

  • The metabolism of high-density lipoproteins.

    abstract::Although high-density lipoproteins (HDLs) have been shown to be the best single indicator of the risk of coronary heart disease (CHD), relatively little is known about their metabolism. Accordingly, only limited strategies are available for therapeutically raising plasma HDL levels. The circulating HDL particle is ass...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章


    authors: Lacko AG

    更新日期:1994-03-01 00:00:00

  • Evolving functions of apolipoprotein AIV: from birds to mammals.

    abstract::Apolipoprotein (apo) AIV is a serum protein that displays particularly vivid dynamics regarding its distribution among the various plasma lipoprotein and nonlipoprotein fractions. This article discusses two main aspects. First, the general functional properties of apo AIV as a highly mobile and versatile apolipoprotei...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Steinmetz A,Schneider WJ

    更新日期:1999-08-01 00:00:00

  • Appropriate dosing of nonvitamin K antagonist oral anticoagulants for stroke prevention in atrial fibrillation.

    abstract::The development of nonvitamin K antagonist oral anticoagulants (NOACs) has been a major advance in therapy for patients requiring oral anticoagulation, particularly for long-term indications such as stroke prevention in atrial fibrillation (AF). The NOACs are generally easier to dose and manage due to less heterogenei...

    journal_title:Trends in cardiovascular medicine

    pub_type: 杂志文章,评审


    authors: Steinberg BA,Washam JB

    更新日期:2017-11-01 00:00:00