Idiopathic myelofibrosis associated with primary biliary cirrhosis.


:A patient with primary biliary cirrhosis (PBC) who developed idiopathic myelofibrosis (IM) is reported. The initial diagnosis of PBC was established by liver biopsy, performed after a 2-month history of constitutional symptoms associated with abnormalities of the serum liver enzymes, with typical serum immunological markers being found. Although a favorable response of PBC to prednisone was observed, one and a half year later the patient developed anemia with anisocytosis and poikilocytosis, tear-drop cells, and leukoerythroblastic picture, and IM was diagnosed by bone marrow biopsy. A few months later, a rapid worsening of the patient's clinical condition was noted, with an increase in the constitutional symptoms and need for frequent packed RBC transfusions, and she finally died from an infectious complication. This case represents a new association of IM with an autoimmune disease, supporting the hypothesis of a possible immune basis of IM in some cases.


Leuk Lymphoma


Leukemia & lymphoma


Hernández-Boluda JC,Jiménez M,Rosiñol L,Cervantes F





Has Abstract


2002-03-01 00:00:00












  • A controlled trial of tranexamic acid therapy for the reduction of bleeding during treatment of acute myeloid leukemia.

    abstract::In order to determine the efficacy of the antifibrinolytic agent tranexamic acid (TA) in reducing bleeding and platelet transfusions during the treatment of acute myeloid leukemia (AML), we conducted a randomized placebo-controlled double-blind study. Patients with AML undergoing induction or postremission consolidati...

    journal_title:Leukemia & lymphoma

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Shpilberg O,Blumenthal R,Sofer O,Katz Y,Chetrit A,Ramot B,Eldor A,Ben-Bassat I

    更新日期:1995-09-01 00:00:00

  • A phase II study of bendamustine in combination with rituximab as initial treatment for patients with indolent non-follicular non-Hodgkin lymphoma.

    abstract::The purpose of this phase 2 study was to determine the activity and safety of six cycles of bendamustine and eight rituximab (RB) as first-line treatment of adult patients with advanced stage non-follicular indolent non-Hodgkin lymphomas (INFL). The primary end-point was the complete response rate (CRR) with expected ...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章,多中心研究


    authors: Luminari S,Goldaniga M,Cesaretti M,Orsucci L,Tucci A,Pulsoni A,Salvi F,Arcaini L,Carella AM,Tedeschi A,Pinto A,Stelitano C,Baldini L

    更新日期:2016-01-01 00:00:00

  • Anthracycline-based consolidation may determine outcome of post-consolidation immunotherapy in AML.

    abstract::Consolidation chemotherapy in acute myeloid leukemia (AML) aims at eradicating residual leukemic cells and mostly comprises high-dose cytarabine with or without the addition of anthracyclines, including daunorubicin. Immunogenic cell death (ICD) may contribute to the efficacy of anthracyclines in solid cancer, but the...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Aurelius J,Möllgård L,Kiffin R,Ewald Sander F,Nilsson S,Thorén FB,Hellstrand K,Martner A

    更新日期:2019-11-01 00:00:00

  • Therapeutic experience of adult acute myeloid leukemia in a single institution of China and its relationship with chromosome karyotype.

    abstract::One hundred and ninety-six untreated de novo acute myeloid leukemia (AML) patients were treated with homoharringtonine + cytosine arabinoside (HA) based induction therapy composed of three chemotherapeutic drugs (HAD/M, D-daunorubicin-DNR, M-mitozantrone-MTZ) used in our hospital for the past 12 years. The patient pop...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Mi Y,Xue Y,Yu W,Liu S,Zhao Y,Meng Q,Bian S,Wang J

    更新日期:2008-03-01 00:00:00

  • Comparison of clinical features and survival between young and old chronic lymphocytic leukemia patients: a single center study from Turkey.

    abstract::We aimed to investigate whether the clinical characteristics, the rate of treatment demand and survival differ between chronic lymphocytic leukemia (CLL) patients <65 years (y) and ≥65 y. Sixty three (46%) patients were <65 y and 74 (54%) were ≥65 y. 28.6% (18/63) of the patients <65 required treatment, while this rat...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Eren R,Karişmaz A,Karataş D,Doğu MH,Altindal Ş,Yokuş O,Suyani E

    更新日期:2019-03-01 00:00:00

  • Detection of residual disease in acute lymphoblastic leukemia of childhood.

    abstract::Several techniques developed in recent years provide us with the capability to detect sub-microscopic leukemia during remission. Quantitative polymerase chain reaction (PCR) is thus far the most sensitive assay that is applicable in most patients with acute lymphoblastic leukemia (ALL) of childhood. However, false-pos...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章,评审


    authors: Estrov Z,Freedman MH

    更新日期:1999-03-01 00:00:00

  • Differences Between Long- and Short-Term Survivors with Lymphoma Type of Adult T-Cell Leukemia.

    abstract::The clinical features at time of diagnosis of long-term survivors with lymphoma type of adult T-cell leukemia (ATL) were compared with those of short-term survivors. We had 51 Japanese patients with lymphoma type of ATL from 1981 to 1989 who had human T-cell leukemia virus type I (HTLV-I) antibody and monoclonal integ...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Shimamot Y,Suga K,Igarashi H,Nishimura J,Nawata H,Yamaguchi M

    更新日期:1990-01-01 00:00:00

  • Improved survival using an intensive, pediatric-based chemotherapy regimen in adults with T-cell acute lymphoblastic leukemia.

    abstract::All patients with newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL) and treated over a 17-year period at a single institution were retrospectively analyzed. From 1990 to 2000, 40 patients were treated with a variety of adult-based ALL regimens. From 2000 to 2007, a pediatric-based protocol, DFCI (Dana Farber...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Al-Khabori M,Minden MD,Yee KW,Gupta V,Schimmer AD,Schuh AC,Xu W,Brandwein JM

    更新日期:2010-01-01 00:00:00

  • Pathogenesis of HIV-1 infection within bone marrow cells.

    abstract::Mononuclear phagocytic cells and CD4+ T lymphocytes represent the major targets for infection by HIV-1 in vivo. The most severe pathogenic features associated with HIV-1 infection can be attributed to malfunction or premature death of these cells that are of hematopoietic origin. Patients with acquired immunodeficienc...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章,评审


    authors: Kulkosky J,Bouhamdan M,Geist A,Nunnari G,Phinney DG,Pomerantz RJ

    更新日期:2000-05-01 00:00:00

  • Prognostic factors in chronic myeloid leukemia. Relationship with interferon and bone marrow transplantation. The Italian Cooperative Study Group on Chronic Myeloid Leukemia.

    abstract::To evaluate the prognostic features of Ph+ CML patients treated by allogeneic BMT or by IFN, we reviewed the data of 50 consecutive pts who were transplanted between 1984 and 1988 and of 180 consecutive patients who were assigned to continuous IFN treatment between 1986 and 1988. In the BMT group, Sokal's system predi...

    journal_title:Leukemia & lymphoma

    pub_type: 临床试验,杂志文章,多中心研究



    更新日期:1993-01-01 00:00:00

  • Characterization of cancer comorbidity prior to allogeneic hematopoietic cell transplantation.

    abstract::Higher comorbidity by the hematopoietic cell transplantation-comorbidity index increases rates of non-relapse mortality (NRM) and impairs survival following allogeneic hematopoietic transplantation. We explored the effects of cancer as a comorbid condition prior to allogeneic transplantation. Among 356 adult transplan...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: D'Angelo CR,Novitsky B,Mee Lee S,Godley LA,Kline J,Larson RA,Liu H,Odenike O,Stock W,Bishop MR,Artz AS

    更新日期:2019-03-01 00:00:00

  • Increased circulating CD3+ T cells are associated with early relapse following autologous hematopoietic stem cell transplantation in patients with classical Hodgkin lymphoma.

    abstract::Non-malignant host immune cells are the main substrate in classical Hodgkin lymphoma (HL) microenvironment. Reconstitution of lymphocyte populations following the high-dose chemotherapy (HDC) with autologous hematopoietic stem cell transplantation (auto-HSCT) can support tumor growth in HL patients. We investigated re...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Batorov EV,Pronkina NV,Tikhonova MA,Kryuchkova IV,Sergeevicheva VV,Sizikova SA,Ushakova GY,Aristova TA,Batorova DS,Shishkova IV,Gilevich AV,Shevela EY,Ostanin AA,Chernykh ER

    更新日期:2019-10-01 00:00:00

  • Immunological changes with kinase inhibitor therapy for chronic lymphocytic leukemia.

    abstract::Ibrutinib and idelalisib are kinase inhibitors that have revolutionized the treatment of chronic lymphocytic leukemia (CLL). Capable of inducing durable remissions, these agents also modulate the immune system. Both ibrutinib and idelalisib abrogate the tumor-supporting microenvironment by disrupting cell-cell interac...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章,评审


    authors: Pleyer C,Wiestner A,Sun C

    更新日期:2018-12-01 00:00:00

  • Bone marrow transplantation in hemophagocytic lymphohistiocytosis.

    abstract::Two important syndromes of hemophagocytic lymphohistiocytosis (HLH) have to be considered in infants and young children with recurrent fever, organomegaly and cytopenias. Familial hemophagocytic lymphohistiocytosis (FHLH) is a genetically heterogeneous autosomal recessive disease with histiocytic and lymphocytic infil...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章,评审


    authors: Dürken M,Finckenstein FG,Janka GE

    更新日期:2001-03-01 00:00:00

  • Thalidomide and lenalidomide: Mechanism-based potential drug combinations.

    abstract::Thalidomide and its analogue lenalidomide are potent anti-inflammatory, anti-angiogenic and immunomodulatory drugs, successfully used for the treatment of hematological cancers, in particular multiple myeloma (MM). Both drugs reveal a dual mechanism of action: they target tumour cells by direct cytotoxicity and, indir...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章,评审


    authors: Vallet S,Palumbo A,Raje N,Boccadoro M,Anderson KC

    更新日期:2008-07-01 00:00:00

  • Co-expression of HoxA9 and bcr-abl genes in chronic myeloid leukemia.

    abstract::We have analyzed the co-expression of the bcr-abl and HoxA9 genes in the follow-up of patients with chronic myeloid leukemia (CML). In the present work we measured the HoxA9 and bcr-abl gene expression in sequential samples. In all patients, bcr-abl and HoxA9 were expressed at detectable levels in every sample. When t...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Tedeschi FA,Cardozo MA,Valentini R,Zalazar FE

    更新日期:2010-05-01 00:00:00

  • Incidence of secondary neoplasms in patients with acute promyelocytic leukemia treated with all-trans retinoic acid plus chemotherapy or with all-trans retinoic acid plus arsenic trioxide.

    abstract::The incidence and pattern of secondary neoplasms in patients with acute promyelocytic leukemia (APL) treated with all-trans retinoic acid (ATRA)-containing regimens is not well described. We compared 160 patients with APL treated with ATRA plus idarubicin (n = 54) or ATRA plus arsenic trioxide (ATO) (n = 106) for the ...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Eghtedar A,Rodriguez I,Kantarjian H,O'Brien S,Daver N,Garcia-Manero G,Ferrajoli A,Kadia T,Pierce S,Cortes J,Ravandi F

    更新日期:2015-05-01 00:00:00

  • Incidence of sepsis after peripheral blood progenitor cells transplantation: analysis of 86 consecutive hemato oncological patients.

    abstract::The incidence of documented infections after autologous peripheral blood progenitor cells transplantation (PBPCT) was retrospectively evaluated in 86 consecutive patients (47 males 39 females; median age 36 years, range, 18-63) treated in our institution; 83 patients had refractory hematological malignancies (40 non-H...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Salutari P,Sica S,Laurenti L,Leone F,Chiusolo P,Piccirillo N,Micciulli G,Leone G

    更新日期:1998-06-01 00:00:00

  • Panuveitis responsive to 2-CdA: an unusual ocular presentation of hairy cell leukemia.

    abstract::Systemic involvement in hairy cell leukemia (HCL), has rarely been reported but ocular involvement is extremely uncommon. We report an unusual ocular presentation of HCL due to panuveitis with dramatic improvement following treatment with 2-chlorodeoxyadenosine (2-CdA). ...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Zeidman A,Floru S,Robinson A,Polliack A,Djaldeti M,Savir H,Mittelman M

    更新日期:1996-02-01 00:00:00

  • Rituximab therapy in monoclonal IgM-related neuropathies.

    abstract::Monoclonal IgM-related neuropathies constitute a heterogeneous group of disorders, which are generally poorly responsive to treatment. Rituximab, a chimeric monoclonal antibody against the CD20 molecule, has been used with success in patients with neuropathy and monoclonal IgM with anti-MAG or anti-GM1 ganglioside act...

    journal_title:Leukemia & lymphoma

    pub_type: 临床试验,杂志文章


    authors: Kilidireas C,Anagnostopoulos A,Karandreas N,Mouselimi L,Dimopoulos MA

    更新日期:2006-05-01 00:00:00

  • Mediastinal large-cell lymphoma with sclerosis refractory to conventional chemotherapy can respond after daily oral cyclophosphamide.

    abstract::Mediastinal large-cell lymphoma with sclerosis (MLCLS) is a distinctive subtype of non-Hodgkin's lymphoma (NHL) with unique clinicopathology aspects and aggressive behavior. Prompt diagnosis and aggressive chemotherapy followed by consolidation radiotherapy may result in long-term survival in the majority of cases. Ho...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Benboubker L,Linassier C,Delain M,Demuret A,Calais G,Dequin PF,Lamagnere JP,Colombat P

    更新日期:1998-03-01 00:00:00

  • Targeting the bone marrow microenvironment in acute leukemia.

    abstract::Despite individual differences between certain leukemias, the overall survival rate in acute leukemia remains low at approximately 40%. Novel therapeutics, including targeted therapies like tyrosine kinase inhibitors, have been incorporated into treatment regimens, but most have failed at eradicating leukemic stem cel...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章,评审


    authors: Karantanou C,Godavarthy PS,Krause DS

    更新日期:2018-11-01 00:00:00

  • ZAP-70 in B cell malignancies.

    abstract::ZAP-70 has emerged as a protein of potential prognostic importance in chronic lymphocytic leukemia (CLL) following gene expression profiling which compared the 2 well established prognostic sub-sets, those with unmutated and mutated IgVH genes. This protein tyrosine kinase (PTK), known to be of importance in T and NK ...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章,评审


    authors: Orchard J,Ibbotson R,Best G,Parker A,Oscier D

    更新日期:2005-12-01 00:00:00

  • Changing landscape of frontline therapy in chronic lymphocytic leukemia.

    abstract::The therapeutic landscape for chronic lymphocytic leukemia has significantly evolved in recent years as our understanding of the biology of this disease has advanced. Chemoimmunotherapy has been the standard frontline treatment for patients of all age groups with chronic lymphocytic leukemia over the last decade. B-ce...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Bhat SA,Woyach JA

    更新日期:2020-03-01 00:00:00

  • Coping styles, health status and advance care planning in patients with hematologic malignancies.

    abstract::This study evaluated whether measures of psychological well-being, including coping style, are associated with advance care planning (ACP). Data were from the Hematology Communications Study (HEMA-COMM), a prospective observational study of physician-patient communication in patients with hematologic malignancies. ACP...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Loberiza FR Jr,Swore-Fletcher BA,Block SD,Back AL,Goldman RE,Tulsky JA,Lee SJ

    更新日期:2011-12-01 00:00:00

  • Increased serum soluble Fas ligand associated with recurrent B-cell non-Hodgkin's lymphoma after autologous peripheral blood stem cell transplantation.

    abstract::Fas-ligand (FasL) is a member of the tumor necrosis factor family and transmits apoptotic cell death signal by binding to its receptor, Fas. FasL is expressed on the cell surface of activated T-cell and natural killer (NK) cell. It has been shown that the FasL can be released from the cell surface by metalloproteinase...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Kanda Y,Chiba S,Tanaka Y,Kami M,Saito T,Izutsu K,Asai T,Yuji K,Ogawa S,Honda H,Mitani K,Usuki K,Urabe A,Shirakawa K,Yatomi T,Nakamura N,Yazaki Y,Hirai H

    更新日期:1999-08-01 00:00:00

  • B cell chronic lymphocytic leukemia with florid reactive CD4+ T cell lymphocytosis in lymph nodes.

    abstract::This case is of an unusual florid reactive CD4+ T Cell lymphocytosis involving lymph node (LN) and overshadowing residual B chronic lymphocytic leukemia (CLL). A 65 year old female with a 9 year history of untreated B-CLL presented with weight loss, splenomegaly and lymphadenopathy. B-CLL was confirmed on the basis of...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Busmanis I,Hussein S,Feleppa F,Rockman S,Begley CG

    更新日期:1993-01-01 00:00:00

  • Ecotropic viral integration site I regulates alpha1, 6-fucosyl transferase expression and blocks erythropoiesis in chronic myeloid leukemia.

    abstract::Although BCR-ABL is the hallmark genetic abnormality of chronic myeloid leukemia (CML), secondary molecular events responsible for the evolution of the disease to blast crisis are yet to be deciphered. Taking into account the significant association of ecotropic viral integration site I (EVI1) in CML drug resistance, ...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Kuila N,Nayak KB,Halder A,Agatheeswaran S,Biswas G,Biswas S,Pattnayak NC,Chakraborty S

    更新日期:2017-08-01 00:00:00

  • Augmented myeloablative conditioning with thiotepa in acute myeloid leukemia - improved outcomes with similar toxicity.

    abstract::Myeloablative doses of busulfan (Bu) with fludarabine (Flu) have reduced toxicity, however, limited by an increased relapse rate. We aimed to improve outcome of Flu-Bu regimen by augmentation with thiotepa (TT) (10 mg/kg). Eighty-nine patients with AML, 44 patients conditioned with Flu-Bu (group 1), and 45 patients au...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Sheth V,Nachmias B,Grisariu S,Avni B,Or R,Shapira M

    更新日期:2019-03-01 00:00:00

  • Bosutinib, dasatinib, imatinib, nilotinib, and ponatinib differentially affect the vascular molecular pathways and functionality of human endothelial cells.

    abstract::The tyrosine kinase inhibitors (TKIs), nilotinib, ponatinib, and dasatinib (but not bosutinib or imatinib), are associated with vascular adverse events (VAEs) in chronic myeloid leukemia (CML). Though the mechanism is inadequately understood, an effect on vascular cells has been suggested. We investigated the effect o...

    journal_title:Leukemia & lymphoma

    pub_type: 杂志文章


    authors: Gover-Proaktor A,Granot G,Pasmanik-Chor M,Pasvolsky O,Shapira S,Raz O,Raanani P,Leader A

    更新日期:2019-01-01 00:00:00