Induction of human herpesvirus 8 gene expression in a posttransplantation primary effusion lymphoma cell line.

Abstract:

:Human herpesvirus 8 (HHV-8 or Kaposi's sarcoma herpesvirus) is a gamma herpesvirus that is most likely the etiologic agent of both Kaposi's sarcoma and primary effusion lymphoma (PEL), a rare HIV-associated lymphoma. The role of HHV-8 in post-transplant lymphoma is less well characterized. We demonstrate that HHV-8 is constitutively present in LH5-21 cells, an atypical patient derived posttransplant PEL cell line. LH5-21 cells lack detectable Epstein-Barr virus, express T cell-associated surface markers and have undergone immunoglobulin heavy chain gene rearrangement. Incubation with 12-O-tetradecanoyl-phorbol- 13-acetate or butyrate induces high levels of several HHV-8 encoded genes that are associated with lytic replication. The patient from whom this cell line was derived demonstrated a dramatic clinical response to withdrawal of immunosuppressive therapy. While HHV-8 associated PELs in the post-transplant setting are rare, this study suggests that improvement in the host immunologic function might help in the management of some PELs.

journal_name

Leuk Lymphoma

journal_title

Leukemia & lymphoma

authors

Shaw RN,Waller EK,Offermann MK

doi

10.1080/10428190290012173

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

631-4

issue

3

eissn

1042-8194

issn

1029-2403

journal_volume

43

pub_type

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