Abstract:
:Precise regulation of hormone secretion from endocrine cells is of critical importance for the maintenance of animal homeostasis. This is partly enabled through the ability of endocrine cells to adapt dynamically their secretory activity to the physiological demands through complex functional changes. Such a secretory plasticity results from coordinated adaptive changes at several levels of cell function, including hormonal gene expression and biosynthesis, hormone processing, trafficking, storage and release, expression of membrane receptors, activation of signaling pathways, etc. Integration of all these processes at the single cell level defines the secretory status of each of the individual cells producing a given hormone, whose coordinated activity ultimately determines the response of the whole endocrine gland. This short review summarizes our most recent findings on the cellular and molecular elements and mechanisms underlying the secretory plasticity of endocrine cells, obtained from the analysis of distinct aspects of melanotroph cell function.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Peinado JR,Castaño JP,Vázquez-Martínez R,Anouar Y,Tonon MC,Vaudry H,Gracia-Navarro F,Malagón MMdoi
10.1006/gcen.2002.7778keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
4-6issue
1eissn
0016-6480issn
1095-6840pii
S0016648002977786journal_volume
126pub_type
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