Abstract：
:This article reviews recent advances in the knowledge of the role of L-selectin, an adhesion molecule that is expressed on the surface of circulating leucocytes, in animal and human physiology and pathophysiology. After a brief discussion on nomenclature and structure, it progresses through the evidence for expression and regulation of L-selectin, cell collection and purification, physiological function and roles. The special role of knock out mice and monoclonal antibodies in determining a role for L-selectin in inflammatory states is described before proceeding to discuss the importance of L-selectin ligands and shed L-selectin. A second section describes a role for L-selectin in pathophysiological states in animals and man, with special reference to trauma, systemic inflammatory syndromes and sepsis. The review concludes with a summary of the potential role of anti-inflammatory medication and L-selectin blockers in the management of inflammation.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Rainer THdoi
10.1016/s0300-9572(01)00444-0keywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
127-41issue
2eissn
0300-9572issn
1873-1570pii
S0300957201004440journal_volume
52pub_type
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