Abstract:
:The distribution of the cannabinoid CB1 receptor and its relationships with individual endocrine cell types were investigated by immunohistochemistry in the anterior lobe of the Xenopus adenohypophysis. By use of a specific primary antibody raised in rabbit against the amino terminus of the rat CB1, we have found numerous CB1-like-immunoreactive cells distributed throughout all of the pituitary anterior lobe with the exception of the ventrocranial area adjacent to the median eminence of the neurohypophysis. Aided by both double-immunostaining on consecutive serial sections and double-simultaneous immunofluorescence on the same section of the gland, the CB1-like immunoreactivity was compared to some specific hormone immunoreactive cells. CB1 labelings were mainly codistributed, and even colocalized, with lactotrophs and thyrotrophs. Gonadotrophs containing CB1 receptors were also observed. In contrast, corticotrophs, which are located mainly in the ventrocranial pole of the anterior lobe, were generally devoid of CB1. Since nerve terminals immunoreactive to the CB1 antibody were observed within the vascular zone of the median eminence, the possibility that endocannabinoids are involved in the control of some secretory activities of Xenopus pituitary, either indirectly via hypothalamic neurosecretory mechanisms or directly on the pituitary cells, was envisaged. In particular, the present study suggests the occurrence of a direct cannabinergic modulation of the prolactin, gonadotrophin, and thyrotrophin secretions through the CB1 receptor.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Cesa R,Guastalla A,Cottone E,Mackie K,Beltramo M,Franzoni MFdoi
10.1006/gcen.2001.7720keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
17-24issue
1eissn
0016-6480issn
1095-6840pii
S0016648001977202journal_volume
125pub_type
杂志文章abstract::Genetic sex determination leads to gonadal differentiation and ultimately the differences between the sexes in steroid hormone secretion. Gonadal steroidogenesis is critical for the development of a sexually dimorphic phenotype and adult reproductive function. Control of gonadal development and steroidogenesis is unde...
journal_title:General and comparative endocrinology
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doi:10.1016/s0016-6480(02)00019-9
更新日期:2002-06-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
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journal_title:General and comparative endocrinology
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(92)90104-r
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abstract::Mammals generally respond to the important metabolic requirements imposed by thermoregulation and pregnancy by increasing plasma concentrations of glucocorticoid that promote the mobilization of body reserves and enhance energy use by tissues. This study examined the impact of distinct ambient temperatures and reprodu...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2011.02.007
更新日期:2011-05-01 00:00:00
abstract::Using antibodies to the amino-terminal region of human parathyroid hormone-related protein (PTHrP) we have demonstrated PTHrP immunoreactivity in pituitaries and plasma of the sea bream (Sparus aurata). Pituitary cells at two distinct locations contained immunodetectable PTHrP; an anterior group in the rostral pars di...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1993.1156
更新日期:1993-11-01 00:00:00
abstract::Plasma glucagon levels in 11 different teleosts and in dogfish were evaluated using an adapted classical mammalian radioimmunoassay (RIA). The values obtained are considered relative; sensitivity was inferior to the original method, but the validation experiment results are acceptable. The mean value of the coefficien...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(86)90131-0
更新日期:1986-09-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2012.11.027
更新日期:2013-04-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(84)90233-8
更新日期:1984-01-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章,评审
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
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更新日期:1987-02-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
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更新日期:1988-02-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2017.05.004
更新日期:2018-01-15 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章,评审
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更新日期:2003-06-15 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2005.09.005
更新日期:2006-02-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2006.10.011
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2008.08.008
更新日期:2008-11-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
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journal_title:General and comparative endocrinology
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
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更新日期:2019-01-15 00:00:00
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journal_title:General and comparative endocrinology
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2008.04.014
更新日期:2008-06-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2006.11.015
更新日期:2007-03-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
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更新日期:1988-12-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2011.04.024
更新日期:2011-08-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2018.10.008
更新日期:2019-01-01 00:00:00
abstract::Cardiovascular responses to synthetic eel [Asn1, Val5, Gly9]-ANG-I, ANG-III (2-8), and ANG-I (1-7) were measured in conscious and resting freshwater North American eels. Indwelling Doppler flow probes were placed on the ventral and dorsal aortas, a pressure catheter in the lienomesenteric artery, and a peptide deliver...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1995.1025
更新日期:1995-02-01 00:00:00