Abstract：
:Complement receptor type 1 (CR1) is a membrane glycoprotein that acts as a receptor for the C3b, iC3b and C4b fragments of complement. In primates, one function of erythrocytes is to promote safe clearance of immunocomplexes (IC) from the circulation through CR1. Theoretically, in diseases characterized by high levels of circulating IC, an erythrocyte CR1 (CR1/E) deficiency may favor IC deposition in tissues or facilitate inappropriate activation of leukocytes in the circulation. Depression of the cell immune response occurs in paracoccidioidomycosis (PCM), especially in the more severe cases, and is frequently associated with high serum IC levels. In the present study we quantified the number of CR1/E in patients with the acute and chronic forms of PCM before and after treatment and correlated it with serum IC levels and CD4+ and CD8+ T cell concentration in the peripheral blood of these patients. Patients with PCM, particularly those with active disease and who had received treatment for shorter periods of time, had low numbers of CR1/E. In addition, an increase in serum IC concentration and a reduction in the CD4+/CD8+ T cell ratio were observed. After treatment there was a significant increase in mean CR1/E number and a reduction in serum IC levels. In patients with the chronic form of the disease the CD4+/CD8+ T cell ratio tended to increase after treatment and was associated with increased CR1/E levels. These results suggest that the reduction in CR1/E observed in patients is a phenomenon acquired with the disease and that CR1 could play a role in the pathogenesis of PCM.
journal_name
Mycopathologiajournal_title
Mycopathologiaauthors
Teixeira JE,Martinez R,Câmara LM,Barbosa JEdoi
10.1023/a:1013123721376keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
125-33issue
3eissn
0301-486Xissn
1573-0832journal_volume
152pub_type
杂志文章相关文献
MYCOPATHOLOGIA文献大全abstract：:The effects of four mycotoxins, T-2 toxin, deoxynivalenol (DON), ochratoxin A (OTA) and fumonisin B1 (FB1) on the response of bovine peripheral blood mononuclear cells (PBM) in vitro to the mitogens concanavalin A (Con A), phytohaemagglutinin A (PHA) and pokeweed mitogen (PWM) were assayed after 4 days' incubation usi...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1023/a:1006971724678
更新日期：1998-01-01 00:00:00
abstract：:Adult CBA mice showed considerably greater resistance to experimental infection with Aspergillus fumigatus than young animals of the same strain (P less than 0.01). Furthermore, in contrast with the young mice, the susceptibility of the adults was only moderately increased by treatment with cortico-steroids. On the ot...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF00490376
更新日期：1977-02-18 00:00:00
abstract：:Melanin synthesis in Cryptococcus neoformans, catalyzed by phenoloxidase activity, is one of the oldest virulence factors known. However, until now, the relationship between melanin production in C. neoformans and its virulence has been poorly understood. Among different chemical compounds only Fe3+ and Cu2+ cations e...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1023/a:1023376324422
更新日期：2002-01-01 00:00:00
abstract：:The mycoflora of nine varieties of grain sorghum was determined by plating serial dilutions of ground samples on rose bengal-streptomycin agar. Seventeen species of fungi representing 10 genera were identified. Curvularia, Penicillium, Mucor, and Aspergillus were dominant genera. Extracts of P. herquei were highly tox...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF00439062
更新日期：1981-07-10 00:00:00
abstract：:The action of allylamine antifungal agents on Epidermophyton floccosum was studied using scanning electron microscopy. After 7 days of culture on Sabouraud dextrose agar, Epidermophyton floccosum samples were brought in contact with concentrations of 0.2 and 2 micrograms ml-1 and 0.01 and 0.1 micrograms ml-1 of naftif...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF00436392
更新日期：1992-12-01 00:00:00
abstract：:It has been over a decade since Cryptococcus gattii was first recognized as the causative organism of an outbreak of cryptococcosis on Vancouver Island, British Columbia. A number of novel observations have been associated with the study of this emergent pathogen. A novel genotype of C. gattii, VGIIa was described as ...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/s11046-011-9475-x
更新日期：2012-06-01 00:00:00
abstract：:Aspergillus flavus K49 secreted at least two xylanase activities when grown on a medium containing larch (wood) xylan as a sole carbon source. Enzyme activity was assayed using an agar medium containing Remazol Brilliant Blue R conjugated oat spelt xylan as substrate. Crude enzyme preparations were inhibited by Hg(+2)...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/s11046-011-9425-7
更新日期：2011-10-01 00:00:00
abstract：:A model of pulmonary cryptococcosis in immunocompetent rats was developed to better understand the virulence of Cryptococcus gattii. Six isolates were studied, representing four molecular genotypes (VGI-MATα, VGIIa-MATα, VGIIa-MAT a, VGIIb-MATα), obtained from Australia, Vancouver (Canada) and Colombia. These originat...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/s11046-010-9328-z
更新日期：2010-11-01 00:00:00
abstract：:A low molecular weight fraction from chitinase digested cell walls of T. mentagrophytes containing both polysaccharide and peptide moieties was found to have immunological reactivity at both the cellular and humoral level. This fraction (UM2(a)) was further degraded by treatment with either a combination of pronase an...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF00683962
更新日期：1979-02-28 00:00:00
abstract：:The enzymatic profiles of several yeastlike organisms were studied using 19 substrates included in the API ZYM system. The isolates evaluated were: 186 Candida albicans, 19 C. stellatoidea, 4 C. tropicalis, 2 C. parapsilosis, 2 C. pseudotropicalis, 1 C. guilliermondii, 3 C. krusei, 11 Torulopsis (Candida) glabrata, 1 ...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF00436820
更新日期：1983-03-22 00:00:00
abstract：:Cryptococcosis is currently the most common life threatening mycoses found in patients with the acquired immunodeficiency syndrome (AIDS). Extrapulmonary involvement is most frequently seen, especially in the central nervous system and skin. Clinical findings are non-specific, even in patients with meningitis. Thresho...
journal_title：Mycopathologia
pub_type： 杂志文章,评审
doi：10.1007/BF00437205
更新日期：1991-06-01 00:00:00
abstract：:We applied a flow cytometry apparatus (FCM) to differentiating Exophiala dermatitidis, E. moniliae and E. jeanselmei from each other. The wavelength of the argon laser emitted from the FCM was 488 nm and the aperture of nozzle from which the stream of fluid containing single cells was blown out was 100 micron. By irra...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF00441263
更新日期：1988-08-01 00:00:00
abstract：:In order to understand the reproductive biology of pathogenic species in the Sporothrix schenckii complex, we characterized the partial mating type (MAT1-1) loci of Sporothrix schenckii, as well as the S. globosa MAT1-1-1 gene, which encoded 262 amino acid sequences. The data confirmed that the MAT1-1 locus of S. glob...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/s11046-014-9808-7
更新日期：2015-02-01 00:00:00
abstract：:This paper describes four new cases of lymphomas, two Hodgkin lymphomas and two non-Hodgkin lymphomas in patients with paracoccidioidomycosis. All had mycosis diagnosed before lymphomas with Paracoccidioides brasiliensis demonstrated in several lymph nodes, as seen in the disseminated form of the disease. When lymphom...
journal_title：Mycopathologia
pub_type： 杂志文章,评审
doi：10.1007/s11046-014-9851-4
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Experience with aerosolized lipid amphotericin B (aeLAB) as therapy or secondary prophylaxis in patients with invasive pulmonary aspergillosis (IPA) is anecdotal. METHODS:We performed a single-center retrospective cohort study to evaluate the efficacy of systemic antifungal therapy with and without aeLAB in...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/s11046-019-00331-0
更新日期：2019-04-01 00:00:00
abstract：:The susceptibility of 21 strains of Aspergillus (11 of A. fumigatus, 8 of A, niger, and 2 of A. flavus) isolated from human pathologic specimens to Amphotericin B and Miconazole has been comparatively studied. Determination of the minimal inhibitory concentration of both drugs in a liquid medium showed a noticeably va...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF00576365
更新日期：1978-11-10 00:00:00
abstract：:In view of our previous findings that vaccination of mice with Candida albicans ribosomes protects them against experimental systemic candidiasis, the aim of this study was to investigate the effect of this vaccination on the course of infection in immunized animals. Since the kidney is the major target in systemic ca...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF00437281
更新日期：1985-07-01 00:00:00
abstract：:Early diagnosis of invasive aspergillosis (IA) is a challenge. Non-specific clinical and radiologic findings, as well as difficulties in conventional diagnostic method application, may delay correct diagnosis. Nowadays, nucleic acid-based assays have reduced the need for conventional antigen detection and culture-base...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/s11046-020-00424-1
更新日期：2020-04-01 00:00:00
abstract：:The microorganisms capable of producing opportunist infections include the yeast-like organisms of the genus Candida, and the unicellular algae of the genus Prototheca, which share common features and can, therefore, lead to confusion. Their colonies are almost identical and they grow in the same culture media used ro...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1023/a:1006818606851
更新日期：1997-01-01 00:00:00
abstract：:The effect of phytate on the production of aflatoxins by Aspergillus parasiticus and Aspergillus flavus grown on synthetic media was examined. In the absence of pH control (initial pH 4.5-6.5) for A. parasiticus, phytate (14.3 mM) caused a six-fold decrease in aflatoxins in the medium and a ten-fold decrease in those ...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF00436636
更新日期：1984-08-30 00:00:00
abstract：:The Penicillium genera, encompassing about 225 different species of fungi, are naturally present in the environment. These genera are poorly linked to human disease, except for Penicillium marneffei causing septicemia in immunocompromised hosts. Thus, Penicillium species recovered from respiratory tract samples are of...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/s11046-017-0217-6
更新日期：2018-04-01 00:00:00
abstract：:Two hundred strains of the Aspergillus flavus group isolated from groundnuts (peanuts) growing in Israel were examined for their ability to produce mycotoxins in potato dextrose (PD) broth. Almost 77% of the isolates produced aflatoxin; aflatoxins B1 and B2 were formed by most of the isolates. Simultaneous production ...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF01103479
更新日期：1993-06-01 00:00:00
abstract：:A 7-year-old female-spayed, domestic short-haired cat was presented to her veterinarian with a mass on the hind paw. Histopathologic examination of a tissue biopsy revealed nodular pyogranulomatous panniculitis with intralesional pigmented fungal hyphae. A dematiaceous fungal isolate was isolated with a micromorpholog...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/s11046-015-9909-y
更新日期：2015-10-01 00:00:00
abstract：:Steaming one-half of a lot of 9-day-old mycelia of Aspergillus parasiticus NRRL 2999 for 6 min resulted in little or no subsequent degradation of aflatoxin B1 or G1 by these mycelia. The other half of these mycelia was not heat-treated and degraded aflatoxins B1 and G1. Filtrates of the growth substrate which remained...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF00443091
更新日期：1978-09-01 00:00:00
abstract：:Fungal infection is a severe problem in children suffering from cancer. We report a case of a four-year-old girl who was diagnosed with acute lymphoblastic leukemia and multiple Aspergillus niger abscesses at the induction phase of the treatment. She was treated with granulocyte transfusions, liposomal amphotericin B ...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/s11046-012-9563-6
更新日期：2012-12-01 00:00:00
abstract：:The microbiologic and clinical resistance of dermatophytes is seldom reported, and the mechanisms associated with resistance are not well known. This study investigated the effect of efflux pump modulators (EPMs) (i.e., haloperidol HAL and promethazine PTZ) and their inhibiting activity on the minimum inhibitory conce...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/s11046-019-00419-7
更新日期：2020-04-01 00:00:00
abstract：:A total of 227 marine isolates of ubiquitous fungi were cultivated on different media and the secondary metabolite content of the extracts (ethyl acetate/chloroform/methanol 3:2:1) characterized by HPLC. The fungi were secured from animals, plants and sediments of Venezuelan waters (0-10 m) including mangroves and lag...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1023/a:1006961500325
更新日期：1998-01-01 00:00:00
abstract：:As actinomycetoma is more frequent in males than in females, the possibility that hormones might modify the Nocardia brasiliensis growth and the course of experimental actinomycetoma was explored. Five N. brasiliensis strains were grown on Sabouraud agar containing estradiol, progesterone or testosterone, in 3 differe...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF01103779
更新日期：1995-11-01 00:00:00
abstract：:A total of 1,303 sera from 202 patients at risk for disseminated candidiasis were analyzed for the presence of Candida antigen using a commercially available latex agglutination test (Cand-Tec). Twenty-three patients had disseminated candidiasis documented by positive blood cultures, deep biopsy culture and histopatho...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/BF00437148
更新日期：1992-06-01 00:00:00
abstract：:Basidiospores were isolated from the fruiting bodies of Ganoderma infecting oil palms from an estate in Johor and from ornamental palms (including oil palms) from Singapore. The spores were then germinated to obtain homokaryotic mycelia. Based on clamp connection formation in paired hyphal fusions, tester strains were...
journal_title：Mycopathologia
pub_type： 杂志文章
doi：10.1007/s11046-004-4440-6
更新日期：2005-01-01 00:00:00
