In vitro characterization of human intact erythrocytes loaded by enalaprilat.

abstract：:Jurkat, an immortalized cell line derived from human leukemic T lymphocytes, has been employed as an excellent surrogate model of human primary T-cells for the advancement of T-cell biology and their applications in medicine. However, presumably due to its T-cell origin, Jurkat cells are very difficult to transfect. T...

journal_title：Drug delivery

authors： Ayyadevara VSSA,Roh KH

更新日期：2020-12-01 00:00:00

abstract：:In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the...

journal_title：Drug delivery

authors： Liu C,Shan W,Liu M,Zhu X,Xu J,Xu Y,Huang Y

更新日期：2016-07-01 00:00:00

abstract：:The aim of this work was to encapsulate superoxide dismutase (SOD) into biodegradable microparticles by spray-drying technique. The nature of the organic solvent to dissolve the polymer, the method of incorporation of the drug in the organic phase (with or without a surfactant, namely sucrose ester of HLB = 6), the su...

journal_title：Drug delivery

authors： Youan BB

更新日期：2004-05-01 00:00:00

abstract：:In the present study, six different molecular weight diblock copolymer of methoxy poly (ethylene glycol)-b-poly (ε-caprolactone) (MPEG-PCL) were synthesized and characterized and was used for fabrication of etoposide-loaded micelles by nanoprecipitation technique. The particle size and percentage drug entrapment of pr...

journal_title：Drug delivery

authors： Ukawala M,Rajyaguru T,Chaudhari K,Manjappa AS,Pimple S,Babbar AK,Mathur R,Mishra AK,Murthy RS

更新日期：2012-04-01 00:00:00

abstract：:A micelle system modified with α-Conotoxin ImI (ImI), a potently antagonist for alpha7 nicotinic acetylcholine receptor (α7-nAChR) previously utilized for targeting breast cancer, was constructed. Its targeting efficiency and cytotoxicity against non-small cell lung cancer (NSCLC) highly expressing α7-nAChR was invest...

journal_title：Drug delivery

authors： Mei D,Zhao L,Chen B,Zhang X,Wang X,Yu Z,Ni X,Zhang Q

更新日期：2018-11-01 00:00:00

abstract：:The objective of our study was to formulate and evaluate proliposomes in the form of enteric-coated beads using glyburide as a model drug. The beads were enteric coated with Eudragit L-100 by a fluidized bed coating process using triethyl citrate as plasticizer. Content uniformity of glyburide was estimated using HPLC...

journal_title：Drug delivery

authors： Kumar R,Gupta RB,Betageri GV

更新日期：2001-01-01 00:00:00

abstract：:Combinational therapy is usually considered as a preferable approach for effective cancer therapy. Especially, combinational chemo and photothermal therapy is of particular interest due to its high flexibility as well as efficiency. In this article, we the silica nanoparticles (SLN) were surface conjugated with Cetuxi...

journal_title：Drug delivery

authors： Zhang X,Li Y,Wei M,Liu C,Yu T,Yang J

更新日期：2019-12-01 00:00:00

abstract：:Raloxifene (RLX) is a second-generation selective estrogen receptor modulator used to treat osteoporosis in postmenopausal women. RLX fails to be developed into injectable dosage forms due to poor solubility. Although oral formulations are clinically available, the lower bioavailability (<2%) embarrasses the pharmaceu...

journal_title：Drug delivery

authors： Du X,Gao N,Song X

更新日期：2021-12-01 00:00:00

abstract：:In this study, transdermal etodolac-loaded cubosomes were developed in order to relieve patient pain and joints stiffness by providing stable etodolac concentration at the targeting sites through controlled drug delivery via the noninvasive skin route with more sustaining and less frequent dosing. Different ratios and...

journal_title：Drug delivery

authors： Salah S,Mahmoud AA,Kamel AO

更新日期：2017-11-01 00:00:00

abstract：:Bioadhesive sodium alginate microspheres of Metoprolol tartrate (MT) for intranasal systemic delivery were prepared to avoid the first-pass effect, as an alternative therapy to injection, and to obtain improved therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres (Ms) were prepar...

journal_title：Drug delivery

authors： Rajinikanth PS,Sankar C,Mishra B

更新日期：2003-01-01 00:00:00

abstract：:Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic conditions, enteric delivery systems are required. The purpose of this study was to prepare pantopraz...

journal_title：Drug delivery

authors： Comoglu T,Gonul N,Dogan A,Basci N

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:A topical microemulsion (ME)-based hydrogel was developed to enhance permeation of an antifungal drug, sertaconazole (STZL) for effective eradication of cutaneous fungal infection. METHODS:Pseudo-ternary phase diagrams were used to determine the existence of MEs region. ME formulations were prepared with oleic...

journal_title：Drug delivery

authors： Sahoo S,Pani NR,Sahoo SK

更新日期：2016-01-01 00:00:00

abstract：:Hydroxy genkwanin (HGK), a flavonoid compound from natural resources, showed good inhibition against the growth of breast tumor cells. However, the poor solubility restricted the further study and the in vivo drug delivery of HGK. We prepared HGK nanosuspensions by antisolvent precipitation method and investigated the...

journal_title：Drug delivery

authors： Ao H,Li Y,Li H,Wang Y,Han M,Guo Y,Shi R,Yue F,Wang X

更新日期：2020-12-01 00:00:00

abstract：:ALA-loaded nanostructured lipid carrier (ALA-NLC) was designed to improve physicochemical stability and water solubility, and promote sustained release of ALA as well as determine the biocompatibility of ALA-NLC. The ALA-NLC manufactured using hot high-pressure homogenization technique was investigated in terms of siz...

journal_title：Drug delivery

authors： Wang J,Xia Q

更新日期：2014-08-01 00:00:00

abstract：:Non-ionic surfactant vesicles, simply known as niosomes are synthetic vesicles with potential technological applications. Niosomes have the same potential advantages of phospholipid vesicles (liposomes) of being able to accommodate both water soluble and lipid soluble drug molecules control their release and as such s...

journal_title：Drug delivery

authors： Abdelkader H,Alani AW,Alany RG

更新日期：2014-03-01 00:00:00

abstract：:Stealth solid lipid nanoparticles (SSLN) were prepared and evaluated for the effect of evading phagocytic uptake by mouse peritoneal macrophages in situ. Fluorescent SSLNs were prepared by emulsion/evaporation with rhodamine B as the fluorescent marker and polyoxyethylene stearate as stealth agent in a stearic acid ma...

journal_title：Drug delivery

authors： Wang Y,Wu W

更新日期：2006-05-01 00:00:00

abstract：:Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL carboxylic acid dispersions at various molar ratios was carried out using rapid solvent evaporation. Characterization of the dispersions was...

journal_title：Drug delivery

authors： Maher EM,Ali AM,Salem HF,Abdelrahman AA

更新日期：2016-10-01 00:00:00

abstract：:Over the years, research has focused on strategies to increase benefit/risk ratio of corticoids. However, vehicles intended for topical glucocorticoids delivery with an improved benefit/risk ratio are still on demand. The aim of this work was the in vitro and in vivo characterization of cold processed oil-in-water (o/...

journal_title：Drug delivery

authors： Raposo S,Tavares R,Gonçalves L,Simões S,Urbano M,Ribeiro HM

更新日期：2015-01-01 00:00:00

abstract：:This study aimed to evaluate transdermal delivery of vancomycin hydrochloride using the combination of ethosomes as an encapsulating vesicle and iontophoresis. Ethosomes were prepared and evaluated in terms of electrochemical stability. Cathodal iontophoresis of negatively charged ethosomes and anodal iontophoresis of...

journal_title：Drug delivery

authors： Mohammed MI,Makky AM,Teaima MH,Abdellatif MM,Hamzawy MA,Khalil MA

更新日期：2016-06-01 00:00:00

abstract：:To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape....

journal_title：Drug delivery

authors： Fang Y,Xue J,Gao S,Lu A,Yang D,Jiang H,He Y,Shi K

更新日期：2017-12-01 00:00:00

abstract：:The aim of our study was to investigate the enhancing effect of several essential oils in the percutaneous absorption of trazodone hydrochloride (TZN). For this purpose, fennel oil, eucalyptus oil, citronella oil, and mentha oil were applied on the skin membrane in three different ways: included in the transdermal dev...

journal_title：Drug delivery

authors： Das MK,Bhattacharya A,Ghosal SK

更新日期：2006-11-01 00:00:00

abstract：:This work focused on the developmental aspects, pharmacokinetic evaluation, and pharmacological assessment of a drug inclusion complex for a novel camptothecin analog (CA) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Camptothecins analog belong to topoisomerase-I inhibitor class of compounds with proven anti-tumor ac...

journal_title：Drug delivery

authors： Nekkanti V,Karatgi P,Paruchuri S,Pillai R

更新日期：2011-05-01 00:00:00

abstract：:The prevalence of childhood dyslipidemia increases and is considered as an important risk factor for the incidence of cardiovascular disease in the adulthood. To improve dosing accuracy and facilitate the determination of dosing regimens in function of the body weight, the proposed study aims at preparing transdermal ...

journal_title：Drug delivery

authors： Zidan AS,Hosny KM,Ahmed OA,Fahmy UA

更新日期：2016-06-01 00:00:00

abstract：:Our objective was to evaluate the chemotherapeutic potential of oral poly lactide-co-glycolide (PLG, a synthetic polymer) nanoparticle encapsulated ethambutol in combination with PLG-nanoparticle encapsulated-(rifampicin + isoniazid + pyrazinamide) in a murine tuberculosis (TB) model. Our formulation was prepared by t...

journal_title：Drug delivery

authors： Pandey R,Sharma S,Khuller GK

更新日期：2006-07-01 00:00:00

abstract：:Fluoroquinolones are broad-spectrum antimicrobial agents that seem to reach their intracellular target site (DNA gyrase) in Escherichia coli by means of an uptake process through the outer and inner membranes. Delivery of quinolones with liposomes has many advantages than the free form of the drug. Liposomes may repre...

journal_title：Drug delivery

authors： Sezer AD,Akbuğa J,Baş AL

更新日期：2007-01-01 00:00:00

abstract：:The aim of this study was to obtain a stable, amorphous solid dispersion (SD) with Soluplus, prepared by hot-melt extrusion (HME) as an effective and stable oral delivery system to improve the physical stability and bioavailability of the poorly water-soluble simvastatin (SIM), a drug with relatively low Tg. The drug ...

journal_title：Drug delivery

authors： Zhang Y,Liu Y,Luo Y,Yao Q,Zhong Y,Tian B,Tang X

更新日期：2016-07-01 00:00:00

abstract：:In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspens...

journal_title：Drug delivery

authors： Pedersen BT,Larsen SW,Østergaard J,Larsen C

更新日期：2008-01-01 00:00:00

abstract：:Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Her...

journal_title：Drug delivery

authors： Zhan W,Rodriguez Y Baena F,Dini D

更新日期：2019-12-01 00:00:00

abstract：:The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as a model drug. The engineering of this delivery system had two stages, the first stage was tuning of MSP physicochemical properties by complexation with pure phosphatidylcholine or phosp...

journal_title：Drug delivery

authors： Morsi NM,Abdelbary GA,Elshafeey AH,Ahmed MA

更新日期：2017-11-01 00:00:00

abstract：:The purpose of this work is to use biorelevant media to evaluate the robustness of a poorly water soluble weakly basic drug to variations along the gastrointestinal tract (GIT) after incorporation in liquisolid compacts and to assess the success of these models in predicting the in vivo performance. Liquisolid tablets...

journal_title：Drug delivery

authors： Badawy MA,Kamel AO,Sammour OA

更新日期：2016-01-01 00:00:00