Localized herpes simplex lymphadenitis mimicking large-cell (Richter's) transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma.

Abstract:

:We report a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who presented with rapid enlargement of a cervical lymph node due to localized herpes simplex lymphadenitis, which was clinically indistinguishable from large cell (Richter's) transformation. The diagnosis was made by excisional lymph node biopsy, which demonstrated CLL/SLL and zonal necrosis due to herpes simplex infection. The herpetic zone was surrounded by a brisk proliferation of immunoblasts. This case demonstrates the need for excisional biopsy and histologic examination of rapidly enlarging nodes in patients with CLL/SLL. The diagnosis of herpes simplex lymphadenitis in patients with CLL/SLL is especially important because, unlike large cell transformation, the infection usually responds well to treatment.

journal_name

Am J Hematol

authors

Joseph L,Scott MA,Schichman SA,Zent CS

doi

10.1002/ajh.10006

keywords:

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

287-91

issue

4

eissn

0361-8609

issn

1096-8652

pii

10.1002/ajh.10006

journal_volume

68

pub_type

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