Diversity of gene expression in adenocarcinoma of the lung.

Abstract:

:The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival. Gene expression analysis thus promises to extend and refine standard pathologic analysis.

authors

Garber ME,Troyanskaya OG,Schluens K,Petersen S,Thaesler Z,Pacyna-Gengelbach M,van de Rijn M,Rosen GD,Perou CM,Whyte RI,Altman RB,Brown PO,Botstein D,Petersen I

doi

10.1073/pnas.241500798

keywords:

subject

Has Abstract

pub_date

2001-11-20 00:00:00

pages

13784-9

issue

24

eissn

0027-8424

issn

1091-6490

pii

241500798

journal_volume

98

pub_type

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