Hypoperfusion of Wernicke's area predicts severity of semantic deficit in acute stroke.

Abstract:

:Based on earlier findings that the presence of word comprehension impairment (a deficit in the meaning of words, or lexical semantics) in acute stroke was strongly associated with the presence of hypoperfusion or infarct in Wernicke's area, we tested the hypothesis that the severity of word comprehension impairment was correlated with the magnitude of delay in perfusion of Wernicke's area on magnetic resonance perfusion-weighted imaging. Eighty patients were prospectively studied within 24 hours of onset or progression of acute left hemisphere stroke symptoms, with diffusion-weighted imaging, perfusion-weighted imaging, and detailed language tests. For 50 patients without infarct in Wernicke's area, we found a strong Pearson correlation between the rate of errors on a word comprehension test and the mean number of seconds of delay in time-to-peak concentration of contrast in Wernicke's area, relative to the homologous region on the right. These results add further evidence for the crucial role of Wernicke's area (Brodmann's area 22) in word comprehension and indicate that the magnitude of delay on PWI may be a gross indicator of tissue dysfunction.

journal_name

Ann Neurol

journal_title

Annals of neurology

authors

Hillis AE,Wityk RJ,Tuffiash E,Beauchamp NJ,Jacobs MA,Barker PB,Selnes OA

doi

10.1002/ana.1265

keywords:

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

561-6

issue

5

eissn

0364-5134

issn

1531-8249

journal_volume

50

pub_type

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