Abstract:
BACKGROUND:A common clinical observation following surgical periodontal therapy with an enamel matrix derivative (Emdogain) is the improved healing of the soft tissues and the limited inflammation of the operated areas. These clinical observations are empirical and difficult to explain. One of the factors influencing the early wound healing might be a potential antimicrobial effect of Emdogain. AIM:To investigate the effect of Emdogain on the vitality of ex vivo supragingival dental plaque and to compare this effect to that of a standard 0.2% chlorhexidine solution. MATERIALS AND METHODS:24 patients suffering from adult periodontitis were included in the study. At the beginning of the experiment, all participants were given a professional tooth cleaning. For the following 4 days, they had to refrain from any kind of oral hygiene measures. At day 5, from each of the volunteers, a voluminous plaque biofilm sample was taken with a sterile curette from the vestibular surfaces of the 1st lower molars and divided into 5 equal parts. Each part was mounted with 5 microl of the following solutions: (1) NaCl, (2) enamel matrix derivative dissolved in water (EMD), (3) enamel matrix derivative dissolved in the vehicle (Emdogain), (4) vehicle (propylene glycol alginate, PGA), (5) 0.2% chlorhexidine digluconate (CHX). After a reaction time of 2 min the test solutions were sucked off, and subsequently the biofilm was stained with a fluorescence dye. The vitality of the plaque flora after the treatments was evaluated under the fluorescence microscope (VF%). RESULTS:Plaque samples treated with NaCl showed a mean vitality of 76.8+/-8%. The EMD, Emdogain, PGA and CHX showed VF values of 54.4+/-9.2, 21.4+/-10.6%, 19.6+/-11.6% and 32.3+/-11.8%, respectively. Emdogain, PGA and CHX showed statistically highly significant reductions (p<0.0001) in terms of bacteria vitality when compared to water (negative control) and EMD. Both Emdogain and PGA were found to be statistically significantly different compared to CHX (p<0.001) (positive control). CONCLUSION:The results of this study indicate that Emdogain might have an antibacterial effect on the vitality of the ex vivo supragingival dental plaque flora.
journal_name
J Clin Periodontoljournal_title
Journal of clinical periodontologyauthors
Sculean A,Auschill TM,Donos N,Brecx M,Arweiler NBdoi
10.1111/j.1600-051X.2001.281113.xkeywords:
subject
Has Abstractpub_date
2001-11-01 00:00:00pages
1074-8issue
11eissn
0303-6979issn
1600-051Xpii
281113journal_volume
28pub_type
杂志文章abstract::The purpose of this investigation was to analyze the clinical crown of the 3 tooth groups of the maxillary anterior sextant of the permanent dentition of normal subjects with respect to (i) width, length and the width/length ratios and (ii) determine if there is a correlation between tooth dimensions or tooth group ra...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1034/j.1600-051x.1999.260304.x
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:This paper reports a meta-analysis of studies that have investigated the effect of scaling and root planing on periodontal probing depth and attachment loss. MATERIAL AND METHODS:The criteria used for inclusion of studies were as follows: root planing and scaling alone was one of the primary treatment arms; ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,meta分析
doi:10.1034/j.1600-051x.2002.291102.x
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVES:Evaluation of the clinical effect of topical subgingival application of doxycycline gel adjunctively to scaling and root planing (SRP) at furcation sites during supportive periodontal therapy (SPT). MATERIAL AND METHODS:In 39 SPT patients exhibiting at least four pockets > or m with bleeding on probing, SRP...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-051X.2009.01414.x
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the ability of different statistical approaches in finding a statistically significant difference in plaque removal efficiency between brushes in clinical trials. MATERIALS AND METHODS:The approaches, which are evaluated, concern the scores after brushing only, the difference in scores before an...
journal_title:Journal of clinical periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-051X.2005.00735.x
更新日期:2005-06-01 00:00:00
abstract::This study compared the intra-examiner and inter-examiner error of 2 constant force probes to the reading of a conventional manual probe. 3 examiners made repeated examinations of attachment level using a modified Florida probe and a manual North Carolina probe (read to 1 mm or 0.5 mm); relative attachment level measu...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1997.tb01212.x
更新日期:1997-12-01 00:00:00
abstract:AIM:The purpose of this study was to evaluate the relationship between periodontal disease and general health status in community-dwelling elderly using serum albumin concentration as a criterion index of the severity of an underlying disease and nutrition status. METHODS:Serum albumin level was detected by the bromcr...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2005.00901.x
更新日期:2006-05-01 00:00:00
abstract::Although it is established that the immunosuppressant cyclosporin-A (CsA) and calcium antagonists [Nifedipine (Nif) and Diltiazem (Dz)] can independently induce gingival enlargement, little has been documented on the significance of the salivary CsA levels and the combined effect of CsA and a calcium antagonist upon g...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1993.tb00360.x
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to describe self-reported oral health, oral hygiene habits, and frequency of visits to a dentist among pregnant women in Kuwait. MATERIAL AND METHODS:A cross-sectional study with an anonymous structured questionnaire was distributed among 650 pregnant women during May-June 2003, wh...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2005.00770.x
更新日期:2005-07-01 00:00:00
abstract:AIM:This study evaluated the levels of sclerostin (SOST) and Dickkopf (DKK)-1 in the chronic periodontitis (CP) associated with type 2 diabetes (DM) and/or smoking. Relationships between SOST, DDK1, RANKL, OPG, IL-1ß, IL-6 and TNF-α, and pathogens were assessed. MATERIAL AND METHODS:The study population included non-d...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/jcpe.12854
更新日期:2018-03-01 00:00:00
abstract:AIM:To develop and validate a condition specific measure of oral health-related quality of life for dentine hypersensitivity (Dentine Hypersensitivity Experience Questionnaire, DHEQ). MATERIALS AND METHODS:Questionnaire construction used a multi-staged impact approach and an explicit theoretical model. Qualitative and...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2010.01618.x
更新日期:2010-11-01 00:00:00
abstract:AIM:The aims were to evaluate and compare the periodontal status of unilateral impacted maxillary canines treated by a combined surgical-orthodontic technique with that of normally erupted controlateral canines. MATERIAL AND METHODS:One hundred and twenty-five patients, consecutively enrolled, aged between 12.8 and 52...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2006.01042.x
更新日期:2007-03-01 00:00:00
abstract::The purpose of this study was to investigate how levels of gingival crevicular fluid (GCF) alkaline phosphatase (ALP) change in relation to levels of plaque and gingival inflammation in 20 adults during a 21 day period of experimental gingivitis. The source of ALP within GCF was also investigated using a repeat sampli...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1996.tb01829.x
更新日期:1996-06-01 00:00:00
abstract::The present clinical trial was designed to evaluate the effects of a bioactive glass, Perioglas, in the treatment of periodontal intrabony defects. 20 patients, 23-55 years of age (44 sites), with intrabony defects completed the 1-year study. Teeth with furcation involvement were excluded. After completion of initial ...
journal_title:Journal of clinical periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-051x.1997.tb00205.x
更新日期:1997-06-01 00:00:00
abstract::The purpose of this study was to evaluate the sensitivity of 4 clinical techniques used in detecting early plaque during a period of dietary sucrose restriction and during a period of sucrose supplementation. The accumulation of plaque during experimental periods of 3 h, 6 h and 18 h was recorded in a group of 38 dent...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1986.tb00862.x
更新日期:1986-08-01 00:00:00
abstract::Individual sites with gain and loss of probing attachment were identified amongst 1688 proximal sites in non-molar teeth from 49 patients monitored for 24 months following oral hygiene instruction and root debridement. The distribution of sites with gain and loss of probing attachment was studied within each of the 49...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1987.tb01548.x
更新日期:1987-08-01 00:00:00
abstract:OBJECTIVE:The objective of this randomized-controlled clinical trial was to evaluate the adjunctive effect of guided tissue regeneration (GTR) using a bioresorbable polylactic acid (PLA) barrier device when combined with autogenous bone grafting in the treatment of deep intra-bony periodontal defects. MATERIAL AND MET...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-051X.2007.01160.x
更新日期:2008-01-01 00:00:00
abstract::This study was undertaken to test the hypothesis that seeded periodontal ligament cells are able to create new attachment. In one beagle dog, a premolar was removed and scrapings of the ligament were cultured. Artificial periodontal defects were made and the cultured ligament cells were seeded on the planed root surfa...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1991.tb01133.x
更新日期:1991-03-01 00:00:00
abstract::The purpose of this investigation was to examine the regeneration of alveolar bone following surgical and non-surgical periodontal treatment. A total of 16 patients who had advanced periodontitis and demonstrated angular bony defects on radiographs participated in the study. After the initial examination, they receive...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1985.tb00940.x
更新日期:1985-09-01 00:00:00
abstract::In the present study, radiographs of a model simulating several degrees of alveolar bone height were taken at different vertical projection angles. Bone height was measured by three examiners utilizing a projection technique similar to that originally employed by Björn et al. (1966, 1969). Correlation coefficients of ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1981.tb00896.x
更新日期:1981-12-01 00:00:00
abstract:AIM:To investigate the association of the Periodontal Risk Assessment (PRA) model categories with periodontitis recurrence and tooth loss during supportive periodontal therapy (SPT) and to explore the role of patient compliance. MATERIAL AND METHODS:In a retrospective cohort, PRA was performed for 160 patients after a...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2009.01508.x
更新日期:2010-02-01 00:00:00
abstract::The aim of the present study was to compare linear measurements of interproximal bone loss on digitized radiographic images after application of different filters to the gold standard of intrasurgical measurements. Immediately before surgery, 50 radiographs of 50 periodontally-diseased teeth exhibiting interproximal b...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1034/j.1600-051x.1999.260506.x
更新日期:1999-05-01 00:00:00
abstract:AIM:The aim of this study was to test whether or not soft tissue augmentation with a collagen matrix (VCMX) leads to a similar increase in ridge width around dental implants compared to the use of an autogenous subepithelial connective tissue graft (SCTG). MATERIALS AND METHODS:In 12 dogs, immediate dental implants we...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/jcpe.12635
更新日期:2017-02-01 00:00:00
abstract:AIMS:The aim of present randomized controlled clinical study was to evaluate the effects of the use of diode laser for graft harvesting and palatal wound irradiation on post-operative morbidity and root coverage outcomes after a coronally advanced flap (CAF) with de-epithelialized gingival grafts (DGG). METHODS:Fifty-...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jcpe.12487
更新日期:2016-01-01 00:00:00
abstract::The purpose of this study was to assess the effect of rinsing and topical application of sanguinarine on labial surface plaque accumulation, compared with topically applied water, and compared with rinsing with chlorhexidine, while refraining from all oral hygiene measures for 5 days. Color photographs of the disclose...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1988.tb01002.x
更新日期:1988-02-01 00:00:00
abstract::The need for periodontal treatment was estimated in a group of the citizens of Oslo. A considerable treatment need was found in spite of the high dentist/population ratio in the area. The need for surgical treatment increased with age. Estimated treatment time was higher in males than in females. ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1975.tb01746.x
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVES:This study evaluated the dimensional ridge alteration in a buccal-bone-deficient extraction socket, and ridge regeneration following socket grafting accompanied by recombinant human bone morphogenetic protein 2 (rhBMP-2) or a collagen membrane covering. MATERIAL AND METHODS:In five beagle dogs, entire bucca...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/jcpe.12414
更新日期:2015-07-01 00:00:00
abstract::The purpose of this cross-sectional epidemiological study was to determine the prevalence of pathologic tooth migration (PTM) among periodontal patients and to investigate the relationship and degree of association between PTM and the following factors: bone loss, tooth loss, gingival inflammation according to the gin...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1997.tb00217.x
更新日期:1997-07-01 00:00:00
abstract::This comparative clinical 9-month study was designed to examine the efficacy of amine/stannous fluoride (AmF/SnF2) (Meridol) and sodium fluoride (NaF). 150 probands with chronic gingivitis or early signs of periodontitis were divided into 3 randomised groups. Group 1 was given a NaF toothpaste and an NaF mouthrinse, g...
journal_title:Journal of clinical periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-051x.1996.tb00560.x
更新日期:1996-04-01 00:00:00
abstract:AIM:Our aim was to measure the association of maternal periodontitis with low birth weight (LBW), pre-term LBW, and intra-uterine growth restriction. MATERIAL AND METHODS:An inclusive case-control design including subjects examined for periodontitis through attachment loss, information on perinatal outcomes and genera...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2006.01012.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:This study was conducted to assess anti-plaque and anti-gingivitis benefits of a stabilized stannous fluoride (SnF(2))/sodium hexametaphosphate (SHMP) dentifrice versus a negative control. MATERIAL AND METHODS:This was a randomized, 6-month, stratified, single-centre, double-blind, parallel group, clinical ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-051X.2007.01109.x
更新日期:2007-09-01 00:00:00