Uremic medium disturbs the hemostatic balance of cultured human endothelial cells.

abstract：:Acid-treated human plasma is a competitive inhibitor of the hydrolysis of D-Val-Leu-Lys-Nan (S-2251) by plasmin. The rate of hydrolysis is decreased to 50% by 750 fold diluted acidified normal plasma and by 60 fold diluted acidified alpha 2-antiplasmin depleted plasma (alpha 2-antiplasmin concentration less than 2%). ...

journal_title：Thrombosis and haemostasis

authors： Lijnen HR,Maes M,Castel M,Samama M,Collen D

更新日期：1982-12-27 00:00:00

abstract：:Hemophilia B is a sex-linked recessive bleeding disorder characterized by the presence of either a decreased amount of normal factor IX (FIX) or the presence of a dysfunctional FIX. We have identified a unique mutation in a family with mild hemophilia B. DNA analysis of family members revealed a single base transition...

journal_title：Thrombosis and haemostasis

authors： Lefkowitz JB,Nuss R,Haver T,Jacobson L,Thompson AR,Manco-Johnson M

更新日期：2001-09-01 00:00:00

abstract：:Compared to second generation, the use of third generation oral contraceptives has been associated with an increased risk of venous thrombosis especially in women with the factor V Leiden mutation. To find an explanation for these risk differences we investigated the effects of desogestrel- and levonorgestrel-containi...

journal_title：Thrombosis and haemostasis

authors： Kemmeren JM,Algra A,Meijers JC,Bouma BN,Grobbee DE

更新日期：2002-02-01 00:00:00

abstract：:We report genetic abnormalities of protein C gene in a male infant who developed neonatal purpura fulminans. DNA-sequence analysis of all exons in protein C gene in this family revealed two mutations. The first abnormality, derived from the mother, was a deletion of one of four consecutive G at nucleotide number 10758...

journal_title：Thrombosis and haemostasis

authors： Ido M,Ohiwa M,Hayashi T,Nishioka J,Hatada T,Watanabe Y,Wada H,Shirakawa S,Suzuki K

更新日期：1993-10-18 00:00:00

abstract：:Primary prevention is the key to managing a significant proportion of the burden of venous thromboembolism (VTE), defined as deep venous thrombosis (DVT) or pulmonary embolism (PE). This is because VTE may lead to sudden death or are often misdiagnosed and therefore treatment is not feasible. Primary prevention usuall...

journal_title：Thrombosis and haemostasis

authors： Granziera S,Cohen AT

更新日期：2015-06-01 00:00:00

abstract：:Recurrent pregnancy loss (PL) is associated with maternal thrombophilia and prophylaxis with low molecular weight heparin (LMWH) can improve pregnancy outcome in this setting. The aim of this study was to investigate the modulation of systemic hemostatic parameters by enoxaparin in women with recurrent PL and to evalu...

journal_title：Thrombosis and haemostasis

authors： Sarig G,Blumenfeld Z,Leiba R,Lanir N,Brenner B

更新日期：2005-11-01 00:00:00

abstract：:A nutritionally induced obesity model was used to investigate the modulation of fibrinolytic and gelatinolytic activity during the development of adipose tissue. Five week old male mice were fed a standard fat diet (SFD, 13% kcal as fat) or a high fat diet (HFD, 42% kcal as fat) for up to 15 weeks. The HFD resulted in...

journal_title：Thrombosis and haemostasis

authors： Lijnen HR,Maquoi E,Demeulemeester D,Van Hoef B,Collen D

更新日期：2002-08-01 00:00:00

abstract：:Coumarin and homologous compounds are the most widely used anticoagulant drugs worldwide. They function as antagonists of vitamin K, an essential cofactor for the posttranslational gamma-glutamyl carboxylation of the so-called vitamin K-dependent proteins. As vitamin K hydroquinone is converted to vitamin K epoxide (V...

journal_title：Thrombosis and haemostasis

authors： Rost S,Fregin A,Hünerberg M,Bevans CG,Müller CR,Oldenburg J

更新日期：2005-10-01 00:00:00

abstract：:We have studied 155 subjects, 48 normals, 36 diabetics without complications, 44 with complications and 27 patients with macroangiopathy. beta-Thromboglobulin (beta-TG) and platelet factor 4 (PF4) are elevated in the patients groups. There is no correlation between the plasma levels of beta-TG and the stages of either...

journal_title：Thrombosis and haemostasis

authors： Fritschi J,Christe M,Lämmle B,Marbet GA,Berger W,Duckert F

更新日期：1984-12-29 00:00:00

abstract：:Graduated elastic compression stockings (GECS) are commonly used in the primary prevention of deep vein thrombosis (DVT); however, their role in preventing recurrent DVT and also post-thrombotic syndrome is less well established. The aim of this review was to investigate the effect of GECS after DVT. A literature sear...

journal_title：Thrombosis and haemostasis

authors： Kakkos SK,Daskalopoulou SS,Daskalopoulos ME,Nicolaides AN,Geroulakos G

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-...

journal_title：Thrombosis and haemostasis

authors： Gebhard C,Maafi F,Stähli BE,Bonnefoy A,Gebhard CE,Nachar W,de Oliveira Moraes AB,Mecteau M,Mihalache-Avram T,Lavoie V,Kernaleguen AE,Shi Y,Busseuil D,Chabot-Blanchet M,Perrault LP,Rhainds D,Rhéaume E,Tardif JC

更新日期：2018-02-01 00:00:00

abstract：:The effect of a basic synthetic peptide, representing the C-terminal region of tissue factor pathway inhibitor (TFPI - Lys254 - Met276), as well as that of the whole protein, on the activity of lipoprotein lipase (LPL) is described. The activity of bovine LPL was measured by chromogenic assay using a water-soluble chr...

journal_title：Thrombosis and haemostasis

authors： Mukherjee M,Kakkar VV

更新日期：1999-12-01 00:00:00

abstract：:A fibrinolysis inhibitor was purified in serum from post-traumatic patients by the use of flat bed electrofocusing of serum desalted by gel chromatography followed by affinity chromatography on a column of matrix-linked plasminogen. Disc gel electrophoresis yielded one protein band. The inhibitor protein was also foun...

journal_title：Thrombosis and haemostasis

authors： Bagge L,Björk I,Saldeen T,Wallin R

更新日期：1978-02-28 00:00:00

abstract：:We compared the anticoagulant, antithrombotic and bleeding effects of highly sulfated dermatan sulfates from invertebrates and their mammalian counterpart. An invertebrate dermatan sulfate containing 2-O-sulfated alpha-L-iduronic acid and 4-O-sulfated N-acetyl-beta-D-galactosamine residues is a potent anticoagulant du...

journal_title：Thrombosis and haemostasis

authors： Vicente CP,Zancan P,Peixoto LL,Alves-Sá R,Araújo FS,Mourão PA,Pavão MS

更新日期：2001-11-01 00:00:00

abstract：:Recombinant human factor VIIa (rFVIIa; NovoSeven) is a two-chain activated clotting factor that is used in the treatment of haemophilia. The distribution of radioactivity in male and pregnant and non-pregnant female rats has been examined by whole-body autoradiography (WBA) after single intravenous doses of 125I-radio...

journal_title：Thrombosis and haemostasis

authors： Beeby TL,Chasseaud LF,Taylor T,Thomsen MK

更新日期：1993-09-01 00:00:00

abstract：:Some correlations between plasma and platelet fatty acids (FA) were evaluated "ex vivo" in 94 normal subjects. The highest relationships between total FA from plasma and platelets were found for 18:1 (r = 0.74) and 18:2 (r = 0.67). Low correlations were obtained for free fatty acids (FFA). The most significant correla...

journal_title：Thrombosis and haemostasis

authors： Vallés J,Aznar J,Santos MT

更新日期：1984-12-29 00:00:00

abstract：BACKGROUND: Clinical effectiveness of recombinant human soluble thrombomodulin (rhTM) in sepsis or sepsis-induced coagulopathy remains a matter of dispute. Recently, the Sepsis Coagulopathy Asahi Recombinant LEThrombomodulin (SCARLET) trial, the latest multinational multi-centre phase III randomized controlled trial, w...

journal_title：Thrombosis and haemostasis

authors： Yamakawa K,Murao S,Aihara M

更新日期：2019-01-01 00:00:00

abstract：:We studied the effect of purified immunoglobulins (Ig) from 21 patients with antiphospholipid antibodies (aPL) on factor Va degradation by activated protein C (aPC) on cultured human umbilical vein endothelial cells (HUVEC). Sera from patients were tested on an ELISA aPL assay to determine the isotype with aPL activit...

journal_title：Thrombosis and haemostasis

authors： Borrell M,Sala N,de Castellarnau C,Lopez S,Gari M,Fontcuberta J

更新日期：1992-09-07 00:00:00

abstract：:Without thromboprophylaxis, knee arthroscopy (KA) carries a low to moderate risk of venous thromboembolism. Over 5 million arthroscopies are performed worldwide yearly. It was our study objective to assess the efficacy and safety of rivaroxaban for thromboprophylaxis after therapeutic KA. Patients undergoing KA in nin...

journal_title：Thrombosis and haemostasis

authors： Camporese G,Bernardi E,Noventa F,Bosco M,Monteleone G,Santoro L,Bortoluzzi C,Freguja S,Nardin M,Marullo M,Zanon G,Mazzola C,Damiani G,Maniscalco P,Imberti D,Lodigiani C,Becattini C,Tonello C,Agnelli G,ERIKA Study Gr

更新日期：2016-08-01 00:00:00

abstract：:Patients with diabetes display increased platelet activation. Recent data show a markedly increased risk for cardiovascular events already in pre-diabetic individuals with impaired glucose tolerance (IGT). We investigated whether IGT is associated with platelet activation. Blood samples were collected from young lean ...

journal_title：Thrombosis and haemostasis

authors： Schäfer A,Widder J,Eigenthaler M,Bischoff H,Ertl G,Bauersachs J

更新日期：2004-07-01 00:00:00

abstract：:von Willebrand disease (VWD) is a quantitative or qualitative defect in von Willebrand factor (VWF) resulting in mucocutaneous bleeding symptoms and hemorrhage following hemostatic challenges, such as trauma or surgery. VWD-specific therapy, DDAVP (1-desamino-8-D-arginine vasopressin) and VWF concentrates, is necessar...

journal_title：Thrombosis and haemostasis

authors： Seaman CD,Ragni MV

更新日期：2020-08-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with chemokine-like functions. MIF is a critical mediator of the host immune and inflammatory response. Dysregulated MIF expression has been demonstrated to contribute to various acute and chronic inflammatory conditions as well as cancer developme...

journal_title：Thrombosis and haemostasis

authors： Asare Y,Schmitt M,Bernhagen J

更新日期：2013-03-01 00:00:00

abstract：:Much research in venous thrombotic diseases focuses on the acute thrombotic process such as anticoagulation and risk factors. Deep-vein thrombosis directly leads to post thrombotic syndrome, and this can cause significant patient disability. Little research has focused on the vein wall injury response to the thromboti...

journal_title：Thrombosis and haemostasis

authors： Deroo S,Deatrick KB,Henke PK

更新日期：2010-10-01 00:00:00

abstract：:Edoxaban is an oral direct factor (F)Xa inhibitor in advanced stages of clinical development. The primary objective of the present study was to assess the pharmacodynamics (PD) and safety of enoxaparin 1 mg/kg followed 12 hours (h) post-dose by edoxaban 60 mg, which is the regimen being used in the phase III study of ...

journal_title：Thrombosis and haemostasis

authors： Zahir H,Matsushima N,Halim AB,He L,Zhang G,Lee F,Worland V,Mendell J

更新日期：2012-07-01 00:00:00

abstract：:Increased procoagulant activity in the alveolar compartment and uncontrolled inflammation are hallmarks of the acute respiratory distress syndrome (ARDS). Here, we investigated whether the contact phase system of coagulation is activated and may regulate inflammatory responses in human lungs. Components of the contact...

journal_title：Thrombosis and haemostasis

authors： Hess R,Wujak L,Hesse C,Sewald K,Jonigk D,Warnecke G,Fieguth HG,de Maat S,Maas C,Bonella F,Preissner KT,Weiss B,Schaefer L,Kuebler WM,Markart P,Wygrecka M

更新日期：2017-10-05 00:00:00

abstract：:Cellular adhesion molecules also known as selectins promote recruitment of inflammatory cells into the arterial wall where they interact with lipid particles leading subsequently to plaque formation. The intercellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leuk...

journal_title：Thrombosis and haemostasis

authors： Hoke M,Winter MP,Wagner O,Exner M,Schillinger M,Arnold Z,Mlekusch W,Maurer G,Koppensteiner R,Minar E,Goliasch G

更新日期：2015-08-31 00:00:00

abstract：:Platelet counts were evaluated in 714 patients with advanced non-small cell lung cancer (N-SCLC), small cell carcinoma of the lung (SCCL), and colon cancer entered to a clinical trial. Patients had not received prior chemotherapy. Platelet counts were not different in patients who had received radiation therapy prior ...

journal_title：Thrombosis and haemostasis

authors： Costantini V,Zacharski LR,Moritz TE,Edwards RL

更新日期：1990-12-28 00:00:00

abstract：:It was the study objective to evaluate whether chewing a 180 mg loading dose of ticagrelor versus an equal dose of traditional oral administration, enhances inhibition of platelet aggregation 1 hour (h) after administering a ticagrelor loading dose in non-ST elevation myocardial infarction (NSTEMI) patients. Dual anti...

journal_title：Thrombosis and haemostasis

authors： Asher E,Frydman S,Katz M,Regev E,Sabbag A,Mazin I,Abu-Much A,Kukuy A,Mazo A,Erez A,Berkovitch A,Narodistky M,Barbash I,Segev A,Beigel R,Matetzky S

更新日期：2017-04-03 00:00:00

abstract：:Bernard-Soulier syndrome (BSS) is an autosomal recessive bleeding disorder due to quantitative or qualitative abnormalities in the glycoprotein (GP) Ib/IX/V complex, the platelet receptor for von Willebrand factor. This complex is composed of four subunits, GPIbalpha, GPIbbeta, GPIX and GPV. We describe here the genet...

journal_title：Thrombosis and haemostasis

authors： Kunishima S,Tomiyama Y,Honda S,Fukunishi M,Hara J,Inoue C,Kamiya T,Saito H

更新日期：2000-07-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a central concern in the intensive care unit (ICU). However, little is known about both current practices for VTE prevention in the ICU and the risk for VTE in persons with severe sepsis and septic shock. XPRESS was a randomized, double-blind, placebo-controlled trial of prophylactic he...

journal_title：Thrombosis and haemostasis

authors： Shorr AF,Williams MD

更新日期：2009-01-01 00:00:00