Abstract:
:Behavioral sensitization, the progressive and enduring enhancement of certain stimulant-induced behaviors following repetitive drug use, is mediated in part by dopaminergic pathways known to play a role in drug dependence. It has been theorized that sensitization underlies the development of drug craving and initiates addictive behaviors of drug dependence. We propose that down-regulation of D3 dopamine receptor function contributes to sensitization. Rodent locomotion is regulated by the opposing influence of dopamine receptor subtypes, with D3 stimulation inhibiting and concurrent D1/D2 receptor activation stimulating locomotion. The D3 receptor has greater occupancy than D1 or D2 receptors following stimulant drug administration. Sensitization may therefore result in part from greater accommodation of the inhibitory D3 receptor "brake" on locomotion, leading to progressive locomotion increase following repeated stimulant exposure. Further study is needed to test this proposed model, and to clarify the role of individual dopamine receptor subtypes in sensitization and drug dependence.
journal_name
J Addict Disjournal_title
Journal of addictive diseasesauthors
Richtand NM,Goldsmith RJ,Nolan JE,Berger SPdoi
10.1300/J069v20n03_03keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
19-32issue
3eissn
1055-0887issn
1545-0848journal_volume
20pub_type
杂志文章,评审abstract::This study examined the Community Reinforcement Approach's (CRA) effect on AIDS risk behaviors and the relationship between comorbid psychiatric disorders and the risk for AIDS behavior in opioid dependent patients entering methadone maintenance treatment. Additionally, we looked at AIDS risk behaviors as they related...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v17n04_04
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abstract::Tobacco dependence is prevalent among alcohol dependent patients, and causes increased morbidity and mortality. Concurrent treatment for these disorders may be advantageous, but there are concerns about adverse effects on alcohol treatment outcomes. The Timing of Alcohol and Smoking Cessation (TASC) Study is a randomi...
journal_title:Journal of addictive diseases
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
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journal_title:Journal of addictive diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1300/j069v13n03_06
更新日期:1994-01-01 00:00:00
abstract::The Self-Medication Hypothesis (SMH) is a popular explanation for chemical dependencies. The SMH ignores or leaves out important biological research which has explored the mechanisms of reward, motivation to use alcohol/drugs, as well as the impact on mood of chronic, excessive alcohol/drug use. A new psychology is ne...
journal_title:Journal of addictive diseases
pub_type: 杂志文章,评审
doi:10.1300/J069v12n03_11
更新日期:1993-01-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2010.509278
更新日期:2010-10-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v26n03_08
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To investigate the 2-year outcome of the first 131 crack cocaine users who had been admitted for a period of inpatient treatment. DESIGN:Follow-up study of consecutive patients admitted between 1992 and 1994. SETTING:Inpatient detoxification unit of a public general hospital in São Paulo City, Brazil. PAR...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v20n01_05
更新日期:2001-01-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v18n03_04
更新日期:1999-01-01 00:00:00
abstract::Previous studies have shown significant associations between OPRK1 and susceptibility to opioid dependence and the relationships between libido dysfunction and insomnia among opium addicts who underwent methadone maintenance treatment. The authors investigated the single locus and haplotype association of rs997917, rs...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2014.950026
更新日期:2014-01-01 00:00:00
abstract::Methadone patients who require inhospital detoxification from self-administered clonazepam (CZM) were interviewed. Patients enrolled in drug dependency (DDTP), combined addiction psychiatry (CAPP) and methadone maintenance (MM) were surveyed. Twenty out of 20 DDTP and 15 out of 30 CAPP patients responded indicating no...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/j069v13n02_09
更新日期:1994-01-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2014.969604
更新日期:2014-01-01 00:00:00
abstract::The purpose of this study was to determine the extent to which spiritual orientation was associated with adaptation to therapeutic community treatment. Spiritual orientation was assessed by the Spirituality Self-Rating Scale, a measure consistent with the conceptualization of spirituality typically reflected in Alcoho...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2010.489443
更新日期:2010-07-01 00:00:00
abstract::Questions continue in the literature concerning potential cause and effect relationships between opiate dependency and several organically-based psychiatric disorders. For example, does opiate dependency produce secondary anxiety and dysthymic syndromes in otherwise healthy persons? or is narcotics misuse by a patient...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v14n03_05
更新日期:1995-01-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v13n01_02
更新日期:1994-01-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章,评审
doi:10.1080/10550889709511144
更新日期:1997-01-01 00:00:00
abstract::In an attempt to reduce homelessness and substance abuse, Chicago graduates of short-term inpatient substance abuse programs who lacked domiciles were placed into one of three conditions: (1) a case management only intervention (n = 96), (2) a case management with supported housing intervention (n = 136), or (3) a con...
journal_title:Journal of addictive diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1300/j069v14n04_01
更新日期:1995-01-01 00:00:00
abstract::OxyContin is a controlled-released form of oxycodone indicated for the management of moderate to severe pain. OxyContin diversion and abuse has become a major problem in certain areas of the United States, particularly rural areas and Appalachia. This study undertakes an 18-month retrospective chart review at a privat...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v23n04_01
更新日期:2004-01-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v20n02_07
更新日期:2001-01-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v21n04_04
更新日期:2002-01-01 00:00:00
abstract:INTRODUCTION:The prevalence and treatment outcome of smokeless tobacco (ST) use among hospitalized addiction patients is unclear. METHODS:Using initially a retrospective and then a prospective study design, data were collected about patients who described "other tobacco use." The data examined included demographics, m...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v21n02_03
更新日期:2002-01-01 00:00:00
abstract::We report the use of naltrexone for treatment of alcohol use disorder in patients with major psychiatric illness. We reviewed the records of 72 mentally ill outpatients treated with naltrexone for alcohol use disorders at a community mental health center. The psychiatric diagnoses included major depression (n = 37), s...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v19n03_05
更新日期:2000-01-01 00:00:00
abstract::The aim of the current investigation was to examine uni-morbid and co-occurring tobacco and marijuana use in relation to the negative emotional symptoms of anxiety and depression. Participants were 250 adult individuals (132 women; mean age = 22.43 years, standard deviation = 9.00 years) who were divided into one of f...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550880903435996
更新日期:2010-01-01 00:00:00
abstract::Alcohol is known to cause elevation of serum total IgE (tIgE). Whether it can predispose to allergic disorders, however, is not clear. To assess whether alcohol can cause sensitization to allergens, we analyzed 100 individuals with alcohol use disorder (AUD) and 50 matched healthy controls. Serum tIgE and specific IgE...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2019.1665964
更新日期:2018-07-01 00:00:00
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
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journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2020.1781346
更新日期:2020-10-01 00:00:00
abstract::Objectives: We used treatment for alcohol withdrawal syndrome as an objective surrogate marker to investigate the relationship between alcohol-related health outcomes and home neighborhood alcohol outlet density and alcohol advertising density.Methods: Mixed effects logistic regression examined whether alcohol outlet ...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2020.1762029
更新日期:2020-07-01 00:00:00