Thrombolysis in deep vein thrombosis: is there still an indication?

Abstract:

:The most accepted therapy for DVT consists of anticoagulation with unfractionated heparin or low molecular weight heparin, followed by variable duration oral anticoagulation but thrombolytic therapy has been proposed in addition to standard anticoagulation. This paper reviews the literature on post thrombotic syndrome, the natural history of vein patency after therapy, and we perform a systematic review, using accepted standards for meta-analysis, to determine the outcomes when thrombolytic therapy is used to treat DVT. We demonstrate that thrombolytic therapy for DVT results in a significant increase in the risk of major hemorrhage and a significant increase in the rate of vein patency. However, although thrombolytic therapy is advantageous over anticoagulation as measured by early vein patency, a benefit in terms of a reduction in PTS risk, is unproven. Our review also shows that there is no evidence that there is a difference in efficacy between thrombolytic agents or that local therapy differs from systemic therapy. Finally, the potential role of catheter directed therapy is unknown since appropriate trials have not been performed but it is reasonable to use catheter directed therapy in patients with phlegmasia cerulea dolens. We conclude that more work is needed to define the role of thrombolytic therapy but it is too early to abandon this therapeutic modality.

journal_name

Thromb Haemost

authors

Wells PS,Forster AJ

keywords:

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

499-508

issue

1

eissn

0340-6245

issn

2567-689X

pii

01070499

journal_volume

86

pub_type

杂志文章,meta分析
  • Inhibition by recombinant hirudins of experimental venous thrombosis and disseminated intravascular coagulation induced by tissue factor in rats.

    abstract::Antithrombotic potency of recombinant hirudins rHV2, rHV2-Lys47 and rHV2-Arg47 was studied in a model of experimental thrombosis induced by tissue factor in the rat. Venous thrombosis was induced by i.v. injection of 25 mg/kg tissue factor followed by stasis of the inferior vena cava. In this model natural recombinant...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Freund M,Cazenave JP,Courtney M,Degryse E,Roitsch C,Bernat A,Delebassée D,Defreyn G,Maffrand JP

    更新日期:1990-04-12 00:00:00

  • Studies of fibrinogen binding to platelets by flow cytometry: an improved method for studies of platelet activation.

    abstract::Platelet function is dependent upon membrane receptors and their interaction with other proteins. Platelet activation appears to cause a structural change of the glycoprotein IIb/IIIa complex that exposes the fibrinogen binding site, which subsequently binds fibrinogen. Fluorescence-activated flow cytometry (FACS) is ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Lindahl TL,Festin R,Larsson A

    更新日期:1992-08-03 00:00:00

  • Thrombosis and inflammation as multicellular processes: significance of cell-cell interactions.

    abstract::Platelet activation as a result of vascular injury provokes endothelial cells to respond in a manner which limits or reverses the occlusive consequences of platelet accumulation. If the agonistic forces are strong, platelet accumulation is irreversible. In vitro data from our laboratory have repeatedly demonstrated th...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:

    authors: Marcus AJ,Safier LB,Broekman MJ,Islam N,Fliessbach JH,Hajjar KA,Kaminski WE,Jendraschak E,Silverstein RL,von Schacky C

    更新日期:1995-07-01 00:00:00

  • Factor Xa inhibits HMGB1-induced septic responses in human umbilical vein endothelial cells and in mice.

    abstract::Nuclear DNA-binding protein high mobility group box 1 (HMGB1) acts as a late mediator of severe vascular inflammatory conditions, such as sepsis. Activated factor X (FXa) is an important player in the coagulation cascade responsible for thrombin generation, and it influences cell signalling in various cell types by ac...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH14-03-0233

    authors: Lee W,Ku SK,Bae JS

    更新日期:2014-10-01 00:00:00

  • Genetic analysis in Japanese kindreds of congenital type I antithrombin deficiency causing thrombosis.

    abstract::We have identified two novel minor deletions (case 1; -TA or -AT at nucleotide 9831-3 in exon 5 and case 2; -A at nucleotide 7640-1 in exon 4), one novel nonsense mutation (case 3; TAT to TAA at nucleotide 7491 in exon 4), and one recurrent nonsense mutation (case 4; CGA to TGA at nucleotide 5381 in exon 3A) in Japane...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Nakahara Y,Tsuji H,Nakagawa K,Masuda H,Kitamura H,Nishimura H,Kasahara T,Sugano T,Sawada S,Nakagawa M

    更新日期:1997-04-01 00:00:00

  • The recovery of platelet malondialdehyde production after a single intake of aspirin--the effect of dosage.

    abstract::We studied the recovery pattern of platelet malondialdehyde (MDA) formation after a single intake of various doses of aspirin (ASA). In normal subjects, there were striking differences in the recovery pattern between large doses (1,000 or 500 mg) and small doses (100 or 50 mg) of oral ASA. The 2 day lag phase was pres...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Takayama H,Okuma M,Uchino H

    更新日期:1982-08-24 00:00:00

  • Neutrophil Extracellular Traps Enhance Staphylococcus Aureus Vegetation Formation through Interaction with Platelets in Infective Endocarditis.

    abstract::The mechanisms or host factors involved in septic thrombus or vegetation formation in Staphylococcus aureus-induced infective endocarditis (IE) are unclear. Using an experimental endocarditis rat model, here we demonstrated that S. aureus HG001-induced vegetation was composed of bacterial floes encased in aggregated p...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-1678665

    authors: Hsu CC,Hsu RB,Ohniwa RL,Chen JW,Yuan CT,Chia JS,Jung CJ

    更新日期:2019-05-01 00:00:00

  • Response of femoral venous oxygen tension to graduated pressure stockings--possible relationship to deep vein thrombosis.

    abstract::Venous oxygen tension (pO2) was measured in discrete samples of blood obtained through the femoral vein of cardiac catheterisation patients before, during and after application of sustained external graduated pressure in the form of compression stockings (T. E. D. Kendall). There was a significant reduction (p less th...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Okoye GC,Evans JH,Beattie J,Lowe GD,Lorimer AR,Forbes CD

    更新日期:1984-02-28 00:00:00

  • Assessment of the F9 genotype-specific FIX inhibitor risks and characterisation of 10 novel severe F9 defects in the first molecular series of Argentinian patients with haemophilia B.

    abstract::In haemophilia B (HB) (factor IX [FIX] deficiency), F9 genotype largely determines clinical phenotype. Aimed to characterise Argentinian families with HB, this study presents F9 genotype frequencies and their specific FIX inhibitor risk and 10 novel F9 mutations. Ninety-one DNA samples from HB patients and relat...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH12-05-0302

    authors: Radic CP,Rossetti LC,Abelleyro MM,Candela M,Pérez Bianco R,de Tezanos Pinto M,Larripa IB,Goodeve A,De Brasi C

    更新日期:2013-01-01 00:00:00

  • Plasma concentration of von Willebrand factor in acute myocardial infarction.

    abstract::Recent investigations have revealed the crucial role of von Willebrand factor (vWF) in platelet thrombus formation under flow conditions. The plasma concentrations of vWF were measured together with various hemodynamic and hemostatic parameters in 51 cases of acute myocardial infarction. In 10 randomly selected cases,...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Sakai H,Goto S,Kim JY,Aoki N,Abe S,Ichikawa N,Yoshida M,Nagaoka Y,Handa S

    更新日期:2000-08-01 00:00:00

  • Safety and tolerability of an immediate-release formulation of theoral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial fibrillation.

    abstract::AZD0837 is an investigational oral anticoagulant which is converted to the active form, AR-H067637, a selective direct thrombin inhibitor. The present study, a multicentre, randomised, parallel-group, dose-guiding study, assessed the safety and tolerability of an immediate-release formulation of AZD0837 compared with ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1160/TH09-07-0509

    authors: Olsson SB,Rasmussen LH,Tveit A,Jensen E,Wessman P,Panfilov S,Wåhlander K

    更新日期:2010-03-01 00:00:00

  • Differential haemostatic risk factors for pregnancy-related deep-vein thrombosis and pulmonary embolism: a population-based case-control study.

    abstract::Limited data exist on thrombophilia and the risk of venous thrombosis (VT) during pregnancy and postpartum. The objectives of the present study were to investigate the role of haemostatic risk factors for pregnancy-related VT and their phenotypic expression in deep-vein thrombosis (DVT) and pulmonary embolism (PE). To...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH12-05-0350

    authors: Bergrem A,Dahm AE,Jacobsen AF,Sandvik L,Sandset PM

    更新日期:2012-12-01 00:00:00

  • Investigation of the interaction of blood platelets with the coagulation system at the site of plug formation in vivo in man--effect of low-dose aspirin.

    abstract::In 7 healthy volunteers, formation of thrombin (represented by fibrinopeptide A (FPA) generation, alpha-granule release (represented by beta-thromboglobulin [beta TG] release) and the generation of thromboxane B2 (TxB2) were measured in vivo in blood emerging from a template bleeding time incision. At the site of plug...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Kyrle PA,Westwick J,Scully MF,Kakkar VV,Lewis GP

    更新日期:1987-02-03 00:00:00

  • Magnesium inhibits platelet activity--an infusion study in healthy volunteers.

    abstract::Magnesium (Mg) has shown the ability to inhibit arterial thrombus formation in some experimental animal studies. This effect may be due to an inhibition of platelet reactivity as in vitro studies have demonstrated that Mg inhibits platelet aggregation. In order to evaluate the in vivo effect of Mg in humans measuremen...

    journal_title:Thrombosis and haemostasis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Ravn HB,Vissinger H,Kristensen SD,Wennmalm A,Thygesen K,Husted SE

    更新日期:1996-06-01 00:00:00

  • Urinary excretion rate of antithrombin III related antigen in cerebral stroke.

    abstract::The urinary excretion rate of antithrombin III related antigen (AT III RA) was examined in cerebral stroke. The excretion rate of AT III RA in cerebral hemorrhage (CH) was 12.33 +/- 1.61 X 10(-4) ml/min. The patients with CH were further classified into two groups: in group CH-I, whose consciousness state was stupor o...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Matsuo T,Shinomiya K,Okuno S,Matsuo C,Matsuo O

    更新日期:1984-12-29 00:00:00

  • Residual venous obstruction in patients with a single episode of deep vein thrombosis and in patients with recurrent deep vein thrombosis.

    abstract::Residual venous obstruction (RVO) in patients with previous deep vein thrombosis (DVT) of the lower limbs has been suggested as an independent risk factor for recurrent venous thromboembolism (VTE). RVO could be a marker of a persistent prothrombotic state. We have compared the rate of RVO in patients with DVT and a p...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH04-12-0817

    authors: Galli M,Ageno W,Squizzato A,Dentali F,Manfredi E,Steidl L,Venco A

    更新日期:2005-07-01 00:00:00

  • First case of sporadic protein S deficiency due to a novel candidate mutation, Ala 484-->Pro, in the protein S active gene (PROS1).

    abstract::In a series of 16 propositi with symptomatic protein S deficiency and a protein S gene mutation, we identified a sporadic case of a novel mutation that probably affects gene expression. The mutation, a G to C transversion leading to the substitution of Ala 484 by Pro, was not found in the protein S gene of the patient...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Borgel D,Jude B,Aiach M,Gandrille S

    更新日期:1996-06-01 00:00:00

  • Potent inhibition of angiogenesis by D,L-peptides derived from vascular endothelial growth factor receptor 2.

    abstract::Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells and plays a central role in angiogenesis and vasculogenesis. Therefore, VEGF and its receptors VEGFR-1 and VEGFR-2 are prime targets for anti-angiogenic intervention which is thought to be one of the most promising approaches in cancer...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH03-02-0106

    authors: Piossek C,Thierauch KH,Schneider-Mergener J,Volkmer-Engert R,Bachmann MF,Korff T,Augustin HG,Germeroth L

    更新日期:2003-09-01 00:00:00

  • Beneficial Effects of High-Density Lipoproteins on Acquired von Willebrand Syndrome in Aortic Valve Stenosis.

    abstract:BACKGROUND:Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH17-10-0729

    authors: Gebhard C,Maafi F,Stähli BE,Bonnefoy A,Gebhard CE,Nachar W,de Oliveira Moraes AB,Mecteau M,Mihalache-Avram T,Lavoie V,Kernaleguen AE,Shi Y,Busseuil D,Chabot-Blanchet M,Perrault LP,Rhainds D,Rhéaume E,Tardif JC

    更新日期:2018-02-01 00:00:00

  • Effect of fixed minidose warfarin, conventional dose warfarin and aspirin on INR and prothrombin fragment 1 + 2 in patients with atrial fibrillation.

    abstract::The efficacy of conventional dose adjusted oral anticoagulation for stroke prevention in patients with non-valvular atrial fibrillation is well-documented but not considered ideal as primary antithrombotic treatment in elderly patients. The antithrombotic effect of fixed minidose warfarin 1.25 mg/day alone or in combi...

    journal_title:Thrombosis and haemostasis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Koefoed BG,Feddersen C,Gulløv AL,Petersen P

    更新日期:1997-05-01 00:00:00

  • Increased thrombin generation in persons with echogenic carotid plaques.

    abstract::Echolucent carotid plaques are associated with higher risk for future ischemic cerebrovascular events (CVE) than echogenic plaques independent of the degree of stenosis. Elevated markers of thrombin generation are associated with atherosclerotic plaques and are increased in the acute and chronic phases of CVE. The pre...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH07-08-0493

    authors: With Notø AT,Mathiesen EB,Østerud B,Amiral J,Vissac AM,Hansen JB

    更新日期:2008-03-01 00:00:00

  • Gelatinase B (MMP-9) deficiency does not affect murine adipose tissue development.

    abstract::This study was performed to follow up on the observation that gelatinase A (MMP-2) deficiency impairs adipose tissue development in mice. The aim was to evaluate the role of its functional homologue gelatinase B (MMP-9) in adipose tissue growth. MMP-9 antigen levels were determined in lean and in obese women before an...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH09-10-0739

    authors: Van Hul M,Piccard H,Lijnen HR

    更新日期:2010-07-01 00:00:00

  • Severe factor VII deficiency caused by a novel mutation His348 to Gln in the catalytic domain.

    abstract::Factor VII is a vitamin K-dependent zymogen that plays a key role in the initiation of the extrinsic pathway. A severe factor VII deficiency was identified in a 45-year old male whose plasma factor VII antigen was less than 60 ng/ml and expressed 5.2% of normal factor VII activity. DNA sequence analysis of the patient...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Katsumi A,Matsushita T,Yamazaki T,Sugiura I,Kojima T,Saito H

    更新日期:2000-02-01 00:00:00

  • Perioperative bridging anticoagulation during dabigatran or warfarin interruption among patients who had an elective surgery or procedure. Substudy of the RE-LY trial.

    abstract::In patients with atrial fibrillation (AF) who require interruption of dabigatran or warfarin for an elective surgery/procedure, the risks and benefits of perioperative bridging anticoagulation is uncertain.We accessed the database from RE-LY, a randomised trial comparing dabigatran with warfarin for stroke prevention ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH14-04-0305

    authors: Douketis JD,Healey JS,Brueckmann M,Eikelboom JW,Ezekowitz MD,Fraessdorf M,Noack H,Oldgren J,Reilly P,Spyropoulos AC,Wallentin L,Connolly SJ

    更新日期:2015-03-01 00:00:00

  • Effect of altitude on thrombopoietin and the platelet count in healthy volunteers.

    abstract::Although there is evidence that altitude increases the platelet count, its effect on the platelet precursor stimulating factor, thrombopoietin (TPO), is unclear. Unlike erythropoietin, TPO appears largely unresponsive to exogenous signals. In a study in 16 healthy volunteers, we report the effects of altitude exposure...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH04-02-0086

    authors: Hartmann S,Krafft A,Huch R,Breymann C

    更新日期:2005-01-01 00:00:00

  • Fibrinogen fragments X, Y, D and E increase levels of plasma fibrinogen and liver mRNAs coding for fibrinogen polypeptides in rats.

    abstract::Previously, we demonstrated that in vivo regulation of liver fibrinogen synthesis occurs via the fibrinogen mRNA level. However, the molecular regulatory mechanism of fibrinogen synthesis is still not well understood. Fibrinogen or fibrin degradation products might play an important role in regulating fibrinogen synth...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Princen HM,Moshage HJ,Emeis JJ,de Haard HJ,Nieuwenhuizen W,Yap SH

    更新日期:1985-04-22 00:00:00

  • Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity.

    abstract::The ability of cellular fibronectin, found in the vessel wall in a fibrillar conformation, to regulate platelet functions and trigger thrombus formation remains largely unknown. In this study, we evaluated how parietal cellular fibronectin can modulate platelet responses under flow conditions. A fibrillar network was ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH14-11-0958

    authors: Maurer E,Schaff M,Receveur N,Bourdon C,Mercier L,Nieswandt B,Dubois C,Jandrot-Perrus M,Goetz JG,Lanza F,Gachet C,Mangin PH

    更新日期:2015-11-25 00:00:00

  • Two mutations in exon XII of the protein S alpha gene in four thrombophilic families resulting in premature stop codons and depressed levels of mutated mRNA.

    abstract::Sixteen Danish unrelated thrombophilic families with plasma protein S deficiency of type 1 (or III) are currently under investigation in our laboratory for defects in the protein S alpha gene. The present paper describes a part of this work, which deals with the identification and phenotypical presentation of two uniq...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Andersen BD,Lind B,Philips M,Hansen AB,Ingerslev J,Thorsen S

    更新日期:1996-08-01 00:00:00

  • European Concerted Action on Anticoagulation (ECAA)-the multicentre calibration of rabbit and human ECAA reference thromboplastins. Steering Committee.

    abstract::Two candidate ECAA reference preparations have been calibrated in a multicentre exercise at 14 representative national laboratories to provide reference thromboplastin for a large field study in 16 European countries. Two preparations were required because of the established differences in ISI arising from the two mai...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Poller L,Barrowcliffe TW,van den Besselaar AM,Jespersen J,Tripodi A,Houghton D

    更新日期:1996-12-01 00:00:00

  • Platelets adhere to sulfatides by von Willebrand factor dependent and independent mechanisms.

    abstract::Unstimulated human platelets from normal volunteers adhere to sulfatides (galactosylceramide-I3-sulfate) as single cells but do not adhere appreciably to other lipids including gangliosides, neutral glycolipids, phospholipids or cholesterol-3-SO4. Platelet adhesion to sulfatide is saturable and dose-dependent, reaches...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Data RE,Williams SB,Roberts DD,Gralnick HR

    更新日期:1991-05-06 00:00:00