Abstract:
:Mounting evidence suggests that the P-glycoprotein (pgp) efflux pump may be a modulator of bioavailability and a mode of excretion for xenobiotics. Immunohistochemistry was utilized to examine the distribution and inducibility of a pgp like protein in catfish. Immunoreactivity to the MDR C-219 monoclonal antibody was noted primarily in bile canaliculi or bile preductules of the liver, discrete areas of the extratubular region of the kidney and the columnar epithelia of the intestine. Regional differences in pgp content were noted in the intestine with the distal region containing greater pgp levels than the proximal intestine. Dietary administration of vincristine, a prototypic pgp inducer and beta-naphthoflavone an Ah agonist resulted in induction of the C-219 immunoreactivity in the liver and the distal intestine. These results are consistent in location and inducibility with pgp like proteins and support a possible relationship to xenobiotic absorption and/or excretion in the catfish.
journal_name
Mar Environ Resjournal_title
Marine environmental researchauthors
Kleinow KM,Doi AM,Smith AAdoi
10.1016/s0141-1136(00)00116-1keywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
313-7issue
1-5eissn
0141-1136issn
1879-0291pii
S0141-1136(00)00116-1journal_volume
50pub_type
杂志文章abstract::Aim of this study was to evaluate the responsiveness of red mullet (Mullus barbatus) liver detoxification enzymes to PAHs at transcriptional and post-transcriptional levels in the field. Fish were captured in the north-eastern Adriatic Sea, close to an oil refinery. Sixteen PAHs (EPA) were determined in sediments and ...
journal_title:Marine environmental research
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journal_title:Marine environmental research
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doi:10.1016/j.marenvres.2009.04.001
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journal_title:Marine environmental research
pub_type: 杂志文章
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journal_title:Marine environmental research
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journal_title:Marine environmental research
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journal_title:Marine environmental research
pub_type: 杂志文章
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2012.12.003
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2017.10.007
更新日期:2017-12-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2008.08.004
更新日期:2008-12-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2011.08.009
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2013.11.004
更新日期:2014-03-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2019.104778
更新日期:2019-10-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章,评审
doi:10.1016/j.marenvres.2004.10.005
更新日期:2005-08-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2006.10.006
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journal_title:Marine environmental research
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doi:10.1016/j.marenvres.2012.05.001
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2017.10.003
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2011.07.002
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2020.105224
更新日期:2021-01-01 00:00:00
abstract::Some subtidal habitats may experience extremely large diel temperature fluctuations. To explore the potential of subtidal animals to regulate their metabolic processes, we investigated how the oxygen consumption rate (MO2) of the sea urchin Mesocentrotus nudus changes in response to extreme temperature fluctuations by...
journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2019.01.003
更新日期:2019-02-01 00:00:00
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journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2012.10.012
更新日期:2013-02-01 00:00:00
abstract::Endocrine disrupting chemicals (EDCs) interfere with the functioning of the endocrine system, causing reproductive and developmental disturbances in aquatic wildlife. Appearance of intersex gonads and elevated plasma levels of vitellogenin in male fish are well known biomarkers of exposure to xenoestrogenic EDCs. In t...
journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2013.10.009
更新日期:2014-05-01 00:00:00
abstract::We have shown previously that exposure of Atlantic croaker to a PCB mixture (Aroclor 1254) results in impaired reproductive neuroendocrine function. In addition, we have identified hypothalamic tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin (5-hydroxytryptamine) synthesis, as a target of PCB neuro...
journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2004.03.077
更新日期:2004-08-01 00:00:00
abstract::Biochemical characterization of cholinesterase activity (ChE) was carried out on the Antarctic scallop Adamussium colbecki collected in winter 2000 from Campo Icaro (Ross Sea, Antarctica) in order to increase its suitability as a sentinel organism for monitoring the Antarctic environment. The digestive gland, gills an...
journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2004.03.086
更新日期:2004-08-01 00:00:00
abstract::Mummichogs, Fundulus heteroclitus, an estuarine fish with a relatively small home range found along the eastern coast of the United States are well-suited to monitoring contaminant effects, including those of polycyclic aromatic hydrocarbons (PAHs). One of the common PAHs in estuaries is pyrene. We report here on effo...
journal_title:Marine environmental research
pub_type: 杂志文章
doi:10.1016/j.marenvres.2003.11.001
更新日期:2004-06-01 00:00:00
abstract::The blue mussel (Mytilus spp.) is widely used as a bioindicator for monitoring of coastal water pollution (mussel watch programs). Herein we provide a review of this study field with emphasis on: the suitability of Mytilus spp. as environmental sentinels; uptake and bioaccumulation patterns of key pollutant classes; t...
journal_title:Marine environmental research
pub_type: 杂志文章,评审
doi:10.1016/j.marenvres.2017.07.024
更新日期:2017-09-01 00:00:00