[Ames test as biomarker].

Abstract:

BACKGROUND AND OBJECTIVE:The incidence of squamous cell carcinomas in the upper aerodigestive tract has increased worldwide. The main risk factors are chronic tobacco and alcohol consumption. The detection of high-risk persons is important because early diagnosis of these tumors provides a good chance for permanent healing. Biomonitoring programs may help to give precise information about the individual cancer risk among smoking and drinking persons. The aim of this study was to evaluate the Ames test as a biomarker to detect the genotoxicity of saliva. PATIENTS AND METHODS:Saliva specimens of 131 probands were investigated for their genotoxic effects using the Ames test. RESULTS:Our results showed an increased trend of genotoxic activity in the saliva of smokers. A highly significant additional increase of genotoxicity was measured in smoking and drinking individuals. CONCLUSIONS:Our study shows that the Ames test could be used to show genotoxic effects in saliva specimens. In combination with other biomarkers, this test may help to develop a valid concept for detecting cancer-endangered people.

journal_name

HNO

journal_title

HNO

authors

Bloching M,Stephan D,Agha-Mir-Salim P,Berghaus A,Lautenschläger C,Grummt T

doi

10.1007/s001060170094

keywords:

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

440-6

issue

6

eissn

0017-6192

issn

1433-0458

journal_volume

49

pub_type

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