Abstract:
BACKGROUND:Polychlorinated biphenyls (PCBs) are complex mixtures of persistent contaminants that are widespread in the environment. Newborns are exposed across the placenta and through breast feeding. Experimental animal studies have indicated that PCBs are neurotoxic. The neurological effects of these compounds on children are not clear. METHODS:A systematic review of literature on the relation between neurological development in children and exposure to polychlorinated biphenyls. RESULTS:Seven follow up studies evaluated the effect of prenatal exposure to PCBs. Two of these studies evaluated highly exposed children. In newborns, an increase of the abnormal reflexes was observed in all four studies evaluating it. During the first months of life, a decrease in motor skills was observed in four of the five studies that investigated psychomotor development; deficits in the acquisition of cognitive skills were observed only in one study assessing non-highly exposed populations. At 4 years of age, an effect on the cognitive areas was observed in four of the five studies that evaluated it. Postnatal exposure to PCBs through breast feeding was not clearly related to any effect on neurological development. CONCLUSIONS:These studies suggest a subtle adverse effect of prenatal PCBs exposure on child neurodevelopment. Differences in study design, inconsistency in some of the results, and the lack of adequate quantitative exposure data, do not allow the derivation of the degree of risk associated with neurodevelopmental effects at current levels of exposure.
journal_name
J Epidemiol Community Healthjournal_title
Journal of epidemiology and community healthauthors
Ribas-Fitó N,Sala M,Kogevinas M,Sunyer Jdoi
10.1136/jech.55.8.537keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
537-46issue
8eissn
0143-005Xissn
1470-2738journal_volume
55pub_type
杂志文章,评审abstract:STUDY OBJECTIVE:The aim was to estimate the likely burden of cervical cancer in New Zealand over the next two decades, according to whether cervical screening services are made more effective. DESIGN:The study was based on national mortality and incidence data for the periods 1954-87 and 1954-86, respectively. An age-...
journal_title:Journal of epidemiology and community health
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journal_title:Journal of epidemiology and community health
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更新日期:2008-06-01 00:00:00
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journal_title:Journal of epidemiology and community health
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更新日期:2013-03-01 00:00:00
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journal_title:Journal of epidemiology and community health
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更新日期:1981-06-01 00:00:00
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更新日期:1997-12-01 00:00:00
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更新日期:2012-10-01 00:00:00
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journal_title:Journal of epidemiology and community health
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更新日期:2019-03-01 00:00:00
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journal_title:Journal of epidemiology and community health
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更新日期:1985-12-01 00:00:00
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更新日期:2001-10-01 00:00:00
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更新日期:1995-12-01 00:00:00
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更新日期:1996-04-01 00:00:00
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更新日期:2012-11-01 00:00:00
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更新日期:2002-06-01 00:00:00
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更新日期:2005-09-01 00:00:00
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更新日期:2014-08-01 00:00:00
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journal_title:Journal of epidemiology and community health
pub_type: 历史文章,杂志文章
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更新日期:2007-05-01 00:00:00
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journal_title:Journal of epidemiology and community health
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更新日期:2011-04-01 00:00:00
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journal_title:Journal of epidemiology and community health
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更新日期:2018-07-01 00:00:00
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journal_title:Journal of epidemiology and community health
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更新日期:2000-07-01 00:00:00
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journal_title:Journal of epidemiology and community health
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更新日期:2012-12-01 00:00:00
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journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2005.039149
更新日期:2006-01-01 00:00:00