Signal transduction pathways underlying the expression of tissue factor and thrombomodulin in promyelocytic cells induced to differentiate by retinoid acid and dibutyryl cAMP.

abstract：:This study aimed to evaluate the relationship between anaemia and pulmonary embolism (PE) prognosis. We analysed a cohort of 764 patients with acute PE referred to a single center for diagnosis and management. Patients were divided into groups by quartiles of haemoglobin (Hb): Hb < 11.7 g/dl; Hb 11.7 to 12.9 g/dl; Hb ...

journal_title：Thrombosis and haemostasis

authors： Jiménez D,Escobar C,Martí D,Díaz G,César J,García-Avello A,Sueiro A,Yusen RD

更新日期：2009-07-01 00:00:00

abstract：:Carbamylation is a non-enzymatic post-translational modification induced upon exposure of free amino groups to urea-derived cyanate leading to irreversible changes of protein charge, structure and function. Levels of carbamylated proteins increase significantly in chronic kidney disease and carbamylated albumin is con...

journal_title：Thrombosis and haemostasis

authors： Binder V,Bergum B,Jaisson S,Gillery P,Scavenius C,Spriet E,Nyhaug AK,Roberts HM,Chapple ILC,Hellvard A,Delaleu N,Mydel P

更新日期：2017-05-03 00:00:00

abstract：:Circulating endothelial cells (CEC) are considered a promising marker to determine the extent of vascular damage. However, currently available and validated CEC enumeration assays are laborious, time consuming and costly, which limits their clinical utility. Here, we evaluated the feasibility of quantifying mRNA level...

journal_title：Thrombosis and haemostasis

authors： Strijbos MH,van Krimpen BA,Debets R,Kraan J,Sleijfer S,Gratama JW,Lamers CH

更新日期：2010-08-01 00:00:00

abstract：:Recurrent pregnancy loss (PL) is associated with maternal thrombophilia and prophylaxis with low molecular weight heparin (LMWH) can improve pregnancy outcome in this setting. The aim of this study was to investigate the modulation of systemic hemostatic parameters by enoxaparin in women with recurrent PL and to evalu...

journal_title：Thrombosis and haemostasis

authors： Sarig G,Blumenfeld Z,Leiba R,Lanir N,Brenner B

更新日期：2005-11-01 00:00:00

abstract：:Overexpression of plasminogen activator inhibitor-1 (SERPINE1, PAI-1), the major physiological inhibitor of pericellular plasmin generation, is a significant causative factor in the progression of vascular disorders (e.g. arteriosclerosis, thrombosis, perivascular fibrosis) as well as a biomarker and a predictor of ca...

journal_title：Thrombosis and haemostasis

authors： Samarakoon R,Higgins PJ

更新日期：2008-12-01 00:00:00

abstract：:Congenitally abnormal fibrinogen Osaka III with the replacement of gamma Arg-275 by His was found in a 38-year-old female with no bleeding or thrombotic tendency. Release of fibrinopeptide(s) by thrombin or reptilase was normal, but her thrombin or reptilase time in the absence of calcium was markedly prolonged and th...

journal_title：Thrombosis and haemostasis

authors： Yoshida N,Imaoka S,Hirata H,Matsuda M,Asakura S

更新日期：1992-11-10 00:00:00

abstract：:Platelet activation may contribute to the increased risk of thrombotic complications in patients with antiphospholipid antibodies (aPL). The increased urinary excretion of 11-dehydro-thromboxane B2 (11-DH-TXB2) reported in patients with lupus anticoagulant (LA) and/or anticardiolipin antibodies (aCL) reflects in vivo ...

journal_title：Thrombosis and haemostasis

authors： Forastiero R,Martinuzzo M,Carreras LO,Maclouf J

更新日期：1998-01-01 00:00:00

abstract：:Platelet aggregation and fibrinogen binding in whole blood, induced either by ADP or by a 14 amino acid peptide mimicking an N-terminal region of the platelet thrombin receptor (TRP, thrombin receptor activating peptide), have been studied with blood from different species. Aggregation was assessed by counting the num...

journal_title：Thrombosis and haemostasis

authors： Cook NS,Zerwes HG,Tapparelli C,Powling M,Singh J,Metternich R,Hagenbach A

更新日期：1993-09-01 00:00:00

abstract：:Integrins are cell surface adhesion receptors that participate in a variety of important processes throughout the vasculature. Here we summarize some recent findings on the regulation of integrin mediated cellular adhesion. Particular emphasis is placed on the regulation of integrin affinity for ligand (activation), a...

journal_title：Thrombosis and haemostasis

authors： Woodside DG,Liu S,Ginsberg MH

更新日期：2001-07-01 00:00:00

abstract：:Congenital amegakaryocytic thrombocytopaenia (CAMT) is a disorder caused by c-MPL mutations that impair thrombopoietin (TPO) signalling, resulting in a near absence of megakaryocytes (MKs). While this phenotype is consistent in adults, neonates with CAMT can present with severe thrombocytopaenia despite normal MK numb...

journal_title：Thrombosis and haemostasis

authors： Lorenz V,Ramsey H,Liu ZJ,Italiano J Jr,Hoffmeister K,Bihorel S,Mager D,Hu Z,Slayton WB,Kile BT,Sola-Visner M,Ferrer-Marin F

更新日期：2017-12-01 00:00:00

abstract：:We have previously reported that platelets from bleeding Simmental cattle do not aggregate in vitro in response to ADP, collagen and calcium ionophore A23187, though calcium mobilization and myosin light chain phosphorylation do occur. The aggregation abnormality, measured by aggregometry, was ascribed to abnormal cyt...

journal_title：Thrombosis and haemostasis

authors： Frojmovic MM,Wong T,Searcy GP

更新日期：1996-12-01 00:00:00

abstract：:The origin and evolution of venom toxins is a mystery that has evoked much interest. We have recently shown that pseutarin C, a prothrombin activator from Pseudonaja textilis venom, is structurally and functionally similar to mammalian coagulation factor Xa-factor Va complex. Its catalytic subunit is homologous to fac...

journal_title：Thrombosis and haemostasis

authors： Minh Le TN,Reza MA,Swarup S,Kini RM

更新日期：2005-03-01 00:00:00

abstract：:The structural determinants of lipopolysaccharide required for the induction of tissue factor in human umbilical vein endothelial cells were studied. Intact lipid A was essential for the induction of tissue factor whereas the incomplete lipid A precursors lipid IVA and lipid X, as well as monophosphoryl lipid A and ac...

journal_title：Thrombosis and haemostasis

authors： Moldow CF,Bach RR,Staskus K,Rick PD

更新日期：1993-10-18 00:00:00

abstract：:The clinical benefits of unfractionated heparin (UFH) and low molecular weight heparin (LMWH) have been shown in many trials. However, the mode of action of heparin has not been fully elucidated. Thus, we wanted to study the effects of UFH and LMWH in vivo by measuring coagulation activation markers in blood obtained ...

journal_title：Thrombosis and haemostasis

authors： Eichinger S,Wolz M,Nieszpaur-Los M,Schneider B,Lechner K,Eichler HG,Kyrle PA

更新日期：1994-12-01 00:00:00

abstract：:The introduction of venography into patient care was a major advance because it was the first accurate method for the diagnosis of DVT. Compression ultrasound has since become the preferred test for patients with suspected DVT because, unlike venography, it is simple, non-invasive and widely available. Venography has ...

journal_title：Thrombosis and haemostasis

authors： Hirsh J,Ginsberg JS,Chan N,Guyatt G,Eikelboom JW

更新日期：2014-01-01 00:00:00

abstract：:A collaborative study has been organised by NIBSC to examine the performance of FIXa assays between laboratories, and to investigate the need for a standard. Ampoules of 3 materials, one monocomponent concentrate (coded C) and 2 different preparations of purified human FIXa (one proposed reference preparation, coded A...

journal_title：Thrombosis and haemostasis

authors： Gray E,Walker D,Heath A,Barrowcliffe TW

更新日期：1996-12-01 00:00:00

abstract：:Coronary artery disease (CAD) is a multifactorial disease, and family history is the best available tool to assess gene-environment interaction. This study addressed the heritability of quantitative traits, namely lipid, coagulation/fibrinolysis and pro-inflammatory markers in the ongoing family-based Indian Atheroscl...

journal_title：Thrombosis and haemostasis

authors： Rao VS,Khadrinarasimhaih NB,Kanjilal S,Mukerjee M,Kakkar VV

更新日期：2009-08-01 00:00:00

abstract：:Prevention of a secondary response to factor IX by cyclophosphamide was attempted in an 11 year old patient with severe Christmas disease. An antibody to factor IX had been present for 4 years before immunosuppressive therapy was tried. Despite profound lymphopenia, synthesis of factor IX antibody was not depressed. T...

journal_title：Thrombosis and haemostasis

authors： Allain JP,Frommel D

更新日期：1976-08-31 00:00:00

abstract：:An amidrazonophenylalanine derivative, LB30057, inhibits the catalytic activity of thrombin potently by interaction with the active site of thrombin, and has high water solubility. In the present study, we evaluated the effect of LB30057 on the biological activities of thrombin at various tissues, and determined wheth...

journal_title：Thrombosis and haemostasis

authors： Kang KT,Jung BI,Bae ON,Lee MY,Chung SM,Lee JY,Lee SK,Kim IC,Chung JH

更新日期：2003-01-01 00:00:00

abstract：:Many studies showed that the occurrence of cardiovascular and cerebrovascular events exhibits a seasonal and monthly variation. Evidences of a seasonal and monthly variation in the incidence of venous thromboembolism (VTE) are more conflicting. We conducted a systematic review and a meta-analysis of the literature to ...

journal_title：Thrombosis and haemostasis

authors： Dentali F,Ageno W,Rancan E,Donati AV,Galli L,Squizzato A,Venco A,Mannucci PM,Manfredini R

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND: Evaluation of thromboembolic risk is essential in anticoagulated atrial fibrillation (AF) patients. The CHA2DS2-VASc score is largely validated and recommended by most guidelines. The GARFIELD-AF Stroke score has been proposed as an alternative risk score. METHODS: We analyzed warfarin-treated patients fro...

journal_title：Thrombosis and haemostasis

authors： Proietti M,Rivera-Caravaca JM,Esteve-Pastor MA,Marín F,Lip GYH

更新日期：2020-12-09 00:00:00

abstract：:We have investigated the role of two vasoactive substances, nitric oxide (NO)and endothelin (ET), in the pathophysiology of disseminated intravascular coagulation (DIC), using two types of DIC models. Experimental DIC was induced by sustained infusion of 0.1, 1, 10, or 50 mg/kg lipopolysaccharide (LPS), or 3.75 U/kg t...

journal_title：Thrombosis and haemostasis

authors： Asakura H,Okudaira M,Yoshida T,Ontachi Y,Yamazaki M,Morishita E,Miyamoto K,Nakao S

更新日期：2002-10-01 00:00:00

abstract：:Plasma levels of D-dimer have been found useful as a marker of deep venous thrombosis in those patients in whom thrombosis is suspected, but their usefulness in postoperative screening is less clear. We have investigated the relationship of D-dimer to deep venous thrombosis in 90 patients after total hip and knee arth...

journal_title：Thrombosis and haemostasis

authors： Dunn ID,Hui AC,Triffitt PD,Crozier AE,Gregg PJ,Sinclair ME,Armstrong AL,Mitchell VE

更新日期：1994-11-01 00:00:00

abstract：:Megakaryocyte (MK)-derived miRNAs have been detected in platelets. Here, we analysed the expression of platelet and circulating miR-223, miR-26b, miR-126 and miR-140 that might be altered with their target mRNAs in type 2 diabetes mellitus (DM2). MiRNAs were isolated from leukocyte-depleted platelets and plasma sample...

journal_title：Thrombosis and haemostasis

authors： Fejes Z,Póliska S,Czimmerer Z,Káplár M,Penyige A,Gál Szabó G,Beke Debreceni I,Kunapuli SP,Kappelmayer J,Nagy B Jr

更新日期：2017-02-28 00:00:00

abstract：:Recombinant factor VIIa (rFVIIa: NovoSeven; Novo Nordisk) has proven efficacy in the treatment of haemophilic patients with inhibitors. This prospective, double-blind study compared rFVIIa (35 vs. 90 microg/kg) in the initiation and maintenance of haemostasis during and after elective surgery. Patients with inhibitors...

journal_title：Thrombosis and haemostasis

authors： Shapiro AD,Gilchrist GS,Hoots WK,Cooper HA,Gastineau DA

更新日期：1998-11-01 00:00:00

abstract：:Incubation of platelet-rich plasma (PRP) with ouabain, an inhibitor of sodium/potassium ATPase (Na+/K+ ATPase), induced a significant rise in basal platelet intracellular calcium concentration [( Ca2+]i) when measured using fura 2. Ouabain induced an enhanced aggregation response to low doses of collagen in both PRP a...

journal_title：Thrombosis and haemostasis

authors： Lees AD,Wilson J,Orchard CH,Orchard MA

更新日期：1989-11-24 00:00:00

abstract：:Bypassing inhibitors in haemophilia patients is limited to activated (a) Factor(F)VII products. We introduced "FVa activity augmentation" as another bypassing strategy and studied effects of an engineered FVa variant designated superFVa. Procoagulant and clot stabilising properties of superFVa and recombinant human (r...

journal_title：Thrombosis and haemostasis

authors： Bhat V,von Drygalski A,Gale AJ,Griffin JH,Mosnier LO

更新日期：2016-03-01 00:00:00

abstract：:Thrombolytic therapy has become the mainstay of treatment for acute transmural myocardial infarction. Present fibrinolytic regimens have a number of shortcomings, including the failure to induce early and sustained reperfusion in as many as 40-50% of the patients, and to prevent reocclusion in another 10-20% of the pa...

journal_title：Thrombosis and haemostasis

authors： Pislaru SV,Van de Werf F

更新日期：1999-09-01 00:00:00

abstract：:Post-infusion hepatitis is known to occur very frequently in haemophiliacs after treatment with unheated commercial clotting factor concentrates, obtained from large plasma donation pool. On the contrary, single-donor cryoprecipitate is likely to carry a lower risk of transmitting hepatitis. To evaluate this hypothesi...

journal_title：Thrombosis and haemostasis

authors： Morfini M,Rafanelli D,Longo G,Messori A,Ferrini PR

更新日期：1986-12-15 00:00:00

abstract：:We studied a murine monoclonal antibody (211 A6) to von Willebrand factor (vWF) with a view to investigating structure-relationship of plasma vWF. The specificity of this antibody has been substantiated by ELISA tests and indirect immunofluorescence. It reacts with purified vWF, normal plasma but not with plasma or pl...

journal_title：Thrombosis and haemostasis

authors： Jorieux S,de Romeuf C,Samor B,Goudemand M,Mazurier C

更新日期：1987-06-03 00:00:00