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Subclinical hypothyroidism: the state of the art.

Abstract：

:Subclinical hypothyroidism (SH) is a common clinical problem, particularly in adulthood and the elderly. Its prevalence is conditioned by several etiological and risk factors. The highest age- and sex-specific rates are in women over 60. SH may be associated with manifestations of mild thyroid failure, which may reverse under levothyroxine (L-T4) therapy. The risk of progression to overt hypothyroidism is distinctly higher in cases with underlying thyroid disease. A population routine screening is not generally recommended, but screening is encouraged in high-risk groups. L-T4 therapy may be indicated in subjects with TSH levels which are repeatedly and consistently elevated (>10 microIU/ml) and may be considered in those with TSH ranging between 4.5-5.5 and 10 microIU/ml, particularly if anti-thyroid antibodies are positive and/or hypothyroid symptoms are present. Treatment should be based, at least initially, on L-T4 low doses.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Arrigo T,Wasniewska M,Crisafulli G,Lombardo F,Messina MF,Rulli I,Salzano G,Valenzise M,Zirilli G,De Luca F

doi

10.1007/BF03345571

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

79-84

issue

1

eissn

0391-4097

issn

1720-8386

pii

4404

journal_volume

31

pub_type

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