Abstract:
:Two of the most important models to account for the specificity and sensitivity of the T cell receptor (TCR) are the kinetic proofreading and serial ligation models. However, although kinetic proofreading provides a means for individual TCRs to measure accurately the length of time they are engaged and signal appropriately, the stochastic nature of ligand dissociation means the kinetic proofreading model implies that at high concentrations the response of the cell will be relatively nonspecific. Recent ligand experiments have revealed the phenomenon of both negative and positive crosstalk among neighboring TCRs. By using a Monte Carlo simulation of a lattice of TCRs, we integrate receptor crosstalk with the kinetic proofreading and serial ligation models and discover that receptor cooperativity can enhance T cell specificity significantly at a very modest cost to the sensitivity of the response.
journal_name
Proc Natl Acad Sci U S Aauthors
Chan C,George AJ,Stark Jdoi
10.1073/pnas.101113698keywords:
subject
Has Abstractpub_date
2001-05-08 00:00:00pages
5758-63issue
10eissn
0027-8424issn
1091-6490pii
98/10/5758journal_volume
98pub_type
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