Abstract:
OBJECTIVE:To report our experience in treatment of arteriovenous malformations (AVMs) using a new liquid embolic agent, Onyx (Micro Therapeutics, Inc., Irvine, CA). METHODS:Between January 1998 and May 1999, 23 patients (8 men and 15 women) were treated. The patients' average age was 40 years, with seizure being the most common presenting symptom (39%). The average Spetzler-Martin grade on presentation was 3. The average AVM volume before embolization was 14.5 cm3. RESULTS:We observed an average 63% reduction in AVM volume after 129 arterial feeders were embolized. There were four adverse events. Two patients experienced ischemia because of inadvertent occlusion of an arterial feeder. One of these patients made a full recovery, but the other patient had a permanent deficit. Two other patients experienced transient neurological deficits that resolved within 1 week of embolization. Permanent morbidity was thus 4% (1 of 23 patients). There were no deaths. Twelve patients underwent subsequent radiosurgery, and 11 patients had surgery that resulted in complete resection of their AVMs. Histopathological examinations showed mild acute inflammation in specimens resected 1 day after embolization. Chronic inflammatory changes were observed in specimens resected more than 4 days after embolization. In two patients, angionecrosis of the embolized vessels was noted. No evidence of parenchymal hemorrhage was observed in these patients, and vessel wall integrity was maintained as well. CONCLUSION:Onyx is a new nonadhesive liquid embolic agent that has been used to treat 23 patients at our institution with good results. Its nonadhesive nature and ease of use make it a promising agent in the future treatment of AVMs.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Jahan R,Murayama Y,Gobin YP,Duckwiler GR,Vinters HV,Viñuela Fdoi
10.1097/00006123-200105000-00003keywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
984-95; discussion 995-7issue
5eissn
0148-396Xissn
1524-4040journal_volume
48pub_type
杂志文章相关文献
NEUROSURGERY文献大全abstract:OBJECTIVE:Spontaneous intraparenchymal hemorrhage is extremely rare in full-term newborns. Reports to date have been limited to descriptions of individual cases, small groups within larger studies of intracranial hemorrhage, and one series of four patients. Structural lesions are rarely identified, and the majority of ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200105000-00015
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:The most common postoperative complication of the transsphenoidal approach is cerebrospinal fluid (CSF) rhinorrhea. If the dura is widely opened beyond the sellar floor and massive intraoperative CSF leakage is encountered, then the conventional packing method, in which the sella turcica is filled with pieces...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000108780.72365.dc
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Current surgical management guidelines for pediatric spondylolisthesis (PS) are reliant on data from single-center cohorts. OBJECTIVE:To analyze national trends and predictors of short-term outcomes in spinal fusion surgery for PS by performing a retrospective cross-sectional analysis of the Kids' Inpatient...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyx295
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Spinal cord cavernous malformations (CMs) are associated with 2 types of angiographically occult "cryptic venous anomalies," which differ in location with respect to the spinal cord. The anatomic distinction between superficial and intramedullary is important in that the latter heighten the risks of CM resec...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31825d8f9a
更新日期:2012-09-01 00:00:00
abstract::We report the metastasis of a rectal carcinoid to the dura mater of the posterior fossa. The clinical presentation was unusual because of a 10-year latent period between resection of the primary rectal tumor and symptoms and signs of the posterior fossa metastasis; the radiological findings were atypical of a metastas...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-197910000-00017
更新日期:1979-10-01 00:00:00
abstract::A randomized clinical trial of 15 patients with acute spinal cord injuries was performed to test the hypothesis that rotating treatment tables prevent deep venous thrombosis in this population. Four of 5 control (nonrotated) patients developed distal and proximal thrombi, assessed by 125I fibrinogen leg scans and impe...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1227/00006123-198705000-00001
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND:Scalp cirsoid aneurysms are rare subcutaneous arteriovenous fistulae affecting the scalp. They can be easily misdiagnosed and mistreated. OBJECTIVE:To review reported cases of scalp cirsoid aneurysms for their incidence, etiology, clinical presentation, treatment, and outcomes using an illustrative case. M...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyz303
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND IMPORTANCE:This article describes delayed endovascular revascularization in a patient with clinical and radiographic evidence of posterior circulation hemodynamic failure in the setting of intracranial occlusive lesions. CLINICAL PRESENTATION:A 48-year-old man presented with a 6-week history of progress...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e3182186811
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:This study aimed to examine early effects of ex vivo-expanded bone marrow-derived endothelial progenitor cells (EPCs) on focal cerebral ischemia-reperfusion injury. METHODS:EPCs were obtained from mononuclear cells of autologous bone marrow of a rat. After culture on fibronectin-coated dishes for 10 to 14 da...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000229058.08706.88
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:The angle of arteries at bifurcations, as well as the blood flow, are factors of hemodynamic stress on the apical region, where aneurysms often develop. Using images obtained with three-dimensional computed tomographic angiography, we sought to determine the angles between the A1 and A2 segments of the anteri...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006123-199907000-00021
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:To investigate the safety and efficacy of liposomal fasudil in a sustained-release form for the prevention of cerebral vasospasm after subarachnoid hemorrhage (SAH). METHODS:Eighteen rats were divided into three groups, each of which received 2.5 mg/kg of liposomal fasudil, 5 mg/kg of liposomal fasudil, or d...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200104000-00041
更新日期:2001-04-01 00:00:00
abstract::Of 345 patients with tuberous sclerosis complex evaluated at the Mayo Clinic from 1950 to 1989, 23 were identified as having brain tumors. In 20 of the 23, histological or clinical evidence showed the tumor to be a subependymal giant cell astrocytoma. A search of the Mayo Clinic tissue registry yielded 73 giant cell-c...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract:OBJECTIVE:The blood-brain barrier (BBB) is often perceived as a passive membrane. However, evidence has demonstrated that the BBB plays an active role in normal homeostasis and in certain disease processes. METHODS:Approximately 300 peer-reviewed publications that discussed normal or abnormal BBB function were reviewe...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/01.neu.0000097715.11966.8e
更新日期:2004-01-01 00:00:00
abstract::Intraoperative monitoring with electroencephalography and the use of brain protection with steroids, phenytoin, mannitol, and pentobarbital or etomidate were evaluated in 15 patients undergoing operation for an aneurysm of the upper basilar artery. One patient harbored a basilar trunk aneurysm, 1 an aneurysm of the pr...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-198912000-00008
更新日期:1989-12-01 00:00:00
abstract::Somatosensory evoked potentials (SEPs) were recorded continuously during aortic occlusion in sheep, with simultaneous measurement of spinal cord blood flow (SCBF) by radiolabeled microspheres. Aortic occlusion was associated with disappearance of the SEPs in seven of nine sheep in 7.8 +/- 4.1 (SD) minutes. SCBF at the...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198711000-00012
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Accidental vessel occlusion is one major risk of intracranial aneurysm surgery potentially causing cerebral ischemia. The intraoperative assessment of cerebral ischemia remains a technological challenge. OBJECTIVE:As a novel approach, cortical tissue integrity was monitored using simultaneous measurements o...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e3182178bc9
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:Intraoperative rupture (IOR) of an aneurysm is a known risk in the surgical management of intracranial aneurysms. The purpose of this study was to determine the incidence of IOR in a modern surgical series and to assess which factors bear upon it. METHODS:This study retrospectively examined 1269 patients wit...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/01.neu.0000154697.75300.c2
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Length of stay beyond medical readiness (LOS-BMR) leads to increased expenses and higher morbidity related to hospital-acquired conditions. OBJECTIVE:To determine the proportion of admitted neurosurgical patients who have LOS-BMR and associated risk factors and costs. METHODS:We performed a prospective, co...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyaa535
更新日期:2020-12-28 00:00:00
abstract::We report five patients with anterior choroidal artery syndrome after surgery for internal carotid artery aneurysms. All patients suffered hemiparesis, and hemisensory loss and homonymous hemianopsia were identified in 2 patients. The characteristic triad of the syndrome was recognized in only 1 patient. Dominant and ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199207000-00021
更新日期:1992-07-01 00:00:00
abstract::The left middle cerebral artery and both carotid arteries of 17 cats were occluded to evaluate the effects of oxygenated fluorocarbon emulsion on brain ischemia. Carotid and middle cerebral arteries were occluded concurrently for 2 hours, followed by occlusion of the middle cerebral artery only for another 24 hours. S...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198603000-00003
更新日期:1986-03-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Vestibular schwannomas with meningioma islets have been rarely reported in the literature; they have been observed only among patients with neurofibromatosis Type II. We present a case of a sporadic mixed tumor in a patient without neurofibromatosis Type II that was not suspected before surgery...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200008000-00037
更新日期:2000-08-01 00:00:00
abstract::A case of subependymoma of the spinal cord in the cervical region is presented. Our experience with this patient and the seven cases of spinal cord subependymoma previously reported show that this tumor predominates in the cervical region and in males (3:1). Although radical removal is considered the rational goal of ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198904000-00024
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Rugby is characterized by high-speed collisions among the players that predispose them to injuries, particularly to the head, neck, and spine. OBJECTIVE:To evaluate the effectiveness of current neurological injury prevention strategies in rugby union. METHODS:Systematic review in May 2010. We assessed the ...
journal_title:Neurosurgery
pub_type: 杂志文章,meta分析,评审
doi:10.1227/NEU.0b013e3181f209f1
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:The endovascular treatment of carotid-cavernous dural fistulae is becoming the prominent treatment modality for these lesions. The intractability of these lesions and their tendency to recur, especially after previous endovascular treatment sessions, exhausts the available routes and tends to p...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199902000-00113
更新日期:1999-02-01 00:00:00
abstract::The diagnosis of malignant glioma of the optic nerves and chiasm may be difficult because these rare lesions may mimic other suprasellar lesions. We report a case of glioblastoma multiforme of the optic chiasm in which the appearance of the lesion on computed tomographic (CT) scan was consistent with that of craniopha...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198212000-00011
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Heat transfer from bipolar tips to adjacent tissue presents a risk of thermal injury during spine surgery. OBJECTIVE:The present study was designed to determine wither bipolar forceps using a novel heat pipe thermal regulation technology resulted in decreased collateral thermal injury of adjacent tissue com...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000370246.82005.6f
更新日期:2010-07-01 00:00:00
abstract::We report a case of a cerebral arteriovenous malformation presenting as a pseudotumor cerebri syndrome. The lack of mass effect, hemorrhage, or hydrocephalus, in addition to angiographic evidence of high-flow and venous outflow restriction, implicate increased cerebral blood flow and venous hypertension as the mechani...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/00006123-199503000-00020
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:Arteriovenous malformations (AVMs) involving the cerebellum and brainstem are relatively rare lesions that most often present clinically as a result of a hemorrhagic episode. Although these AVMs were once thought to have a more aggressive clinical course in comparison with supratentorial AVMs, recent autopsy ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000204641.38419.2D
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Spinal cord dose limits are critically important for the safe practice of spine stereotactic body radiotherapy (SBRT). However, the effect of inherent spinal cord motion on cord dose in SBRT is unknown. OBJECTIVE:To assess the effects of cord motion on spinal cord dose in SBRT. METHODS:Dynamic balanced fas...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyaa202
更新日期:2020-06-04 00:00:00
abstract::Intracranial hemorrhage during pregnancy is rare. The authors present a case of moyamoya disease associated with pregnancy. A 32-year-old woman who was at 32 weeks of gestation experienced sudden severe headache followed by loss of consciousness. Computed tomography revealed an intracerebral hematoma in the left tempo...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198701000-00009
更新日期:1987-01-01 00:00:00