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Involvement of disregulated c-myc but not c-sis/PDGF in atypical and anaplastic meningiomas.

Abstract：

:We investigated the expression of c-myc and c-sis/PDGF mRNA and protein products in 20 cases of meningiomas of various grades: 10 benign, 5 atypical and 5 anaplastic meningiomas. All cases of atypical and anaplastic meningiomas were positive for c-myc protein and mRNA by immunohistochemistry and in situ hybridisation, respectively, while all 10 benign meningiomas were negative for c-myc immunostaining, with only one benign tumour positive for c-myc mRNA. Expression of PDGF-BB protein and c-sis mRNA were seen in more than 80% of the meningioma cases and was not restricted to the histological grades of meningiomas. Semiquantitative analysis showed that the frequency of c-myc immunopositive cells positively correlated with Ki-67 proliferative indices. Our findings suggest that c-myc, but not c-sis/PDGF, has some concern to the malignancy of meningiomas.

journal_name

Clin Neurol Neurosurg

journal_title

Clinical neurology and neurosurgery

authors

Nagashima G,Aoyagi M,Yamamoto S,Wakimoto H,Tamaki M,Yamamoto K,Fujimoto T,Hirakawa K

doi

10.1016/s0303-8467(00)00119-0

keywords:

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

13-8

issue

1

eissn

0303-8467

issn

1872-6968

pii

S0303-8467(00)00119-0

journal_volume

103

pub_type

杂志文章

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