Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite.

Abstract:

:New and greatly improved preparations of the 12alpha,1'beta- (5) and 12beta,1'beta- (6) glucuronides of dihydroartemisinin (DHA, 2) are reported using anomeric hydroxy and imidate glucuronate intermediates. Comparison of the synthetic and natural materials shows that the human metabolite of DHA is the 12alpha-epimer 5.

journal_name

J Med Chem

authors

O'Neill PM,Scheinmann F,Stachulski AV,Maggs JL,Park BK

doi

10.1021/jm001061a

keywords:

subject

Has Abstract

pub_date

2001-04-26 00:00:00

pages

1467-70

issue

9

eissn

0022-2623

issn

1520-4804

pii

jm001061a

journal_volume

44

pub_type

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