Absence of N-acetylaspartate in the human brain: impact on neurospectroscopy?

Abstract:

:N-acetylaspartate (NAA) contributes to the most prominent signal in proton magnetic resonance spectroscopy (1H-MRS) of the adult human brain. We report the absence of NAA in the brain of a 3-year-old child with neurodevelopmental retardation and moderately delayed myelination. Since normal concentration of NAA in body fluids is hardly detectable, 1H-MRS is a noninvasive technique for identifying neurometabolic diseases with absent NAA. This report puts NAA as a neuronal marker to question.

journal_name

Ann Neurol

journal_title

Annals of neurology

authors

Martin E,Capone A,Schneider J,Hennig J,Thiel T

keywords:

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

518-21

issue

4

eissn

0364-5134

issn

1531-8249

journal_volume

49

pub_type

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