当前位置： SCI文献检索 > JOURNAL OF HUMAN GENETICS期刊下所有文献 > alpha-1-Antichymotrypsin gene A1252G variant (ACT Isehara-1) is associated with a lacunar type of ischemic cerebrovascular disease.

alpha-1-Antichymotrypsin gene A1252G variant (ACT Isehara-1) is associated with a lacunar type of ischemic cerebrovascular disease.

Abstract：

:alpha-1-Antichymotrypsin (ACT) is a plasma protease inhibitor belonging to the serpine superfamily; it has many functions. and thus qualitative change in ACT is likely to result in specific diseases. We previously reported a variant AACT (ACT Isehara-1, Met389Val, A1252G) in patients with ischemic cerebrovascular disease (CVD). The present study was designed to examine the association of the variant with ischemic CVD, in 87 patients and 397 age-matched controls. We found that the frequency of the A1252G variant (ACT Isehara-1) was higher in the group with ischemic CVD than in the control group (P = 0.0397), which appeared to be independent of known risk factors. We subdivided the CVD group into lacunar and atherothrombotic subgroups. Further analysis by subtype of ischemic CVD showed an association of ACT Isehara-1 with lacunar infarction (P = 0.0036). These results suggest that ACT lsehara-1 is a new genetic risk factor for ischemic CVD, especially lacunar-type infarction, in Japan.

journal_name

J Hum Genet

journal_title

Journal of human genetics

authors

Tachikawa H,Tsuda M,Onoe K,Ueno M,Takagi S,Shinohara Y

doi

10.1007/s100380170125

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

45-7

issue

1

eissn

1434-5161

issn

1435-232X

journal_volume

46

pub_type

杂志文章

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