Structure of a flavin-binding plant photoreceptor domain: insights into light-mediated signal transduction.

abstract：:Two deletion-substitution mutations of phage lambda, spi-113 and spi-274, are shown to remove about half of the rightward operator OR. Physiological studies show that spi-113 is still repressible. Thus, the 50 or so nucleotides of OR deleted in this mutant are not absolutely essential for repression. prm-116, which in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith GR,Eisen H,Reichardt L,Hedgepeth J

更新日期：1976-03-01 00:00:00

abstract：:Debate over the influence of postwildfire management on future fire severity is occurring in the absence of empirical studies. We used satellite data, government agency records, and aerial photography to examine a forest landscape in southwest Oregon that burned in 1987 and then was subject, in part, to salvage-loggin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson JR,Spies TA,Ganio LM

更新日期：2007-06-19 00:00:00

abstract：:Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bochar DA,Savard J,Wang W,Lafleur DW,Moore P,Côté J,Shiekhattar R

更新日期：2000-02-01 00:00:00

abstract：:Current drug discovery efforts focus on identifying lead compounds acting on a molecular target associated with an established pathological state. Concerted molecular changes that occur in specific cell types during disease progression have generally not been identified. Here, we used constellation pharmacology to inv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raghuraman S,Xie JY,Giacobassi MJ,Tun JO,Chase K,Lu D,Teichert RW,Porreca F,Olivera BM

更新日期：2020-10-20 00:00:00

abstract：:The marine nitrogen fixing microorganisms (diazotrophs) are a major source of nitrogen to open ocean ecosystems and are predicted to be limited by iron in most marine environments. Here we use global and targeted proteomic analyses on a key unicellular marine diazotroph Crocosphaera watsonii to reveal large scale diel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saito MA,Bertrand EM,Dutkiewicz S,Bulygin VV,Moran DM,Monteiro FM,Follows MJ,Valois FW,Waterbury JB

更新日期：2011-02-08 00:00:00

abstract：:One can imagine a variety of mechanisms that should result in self-perpetuating biological states. It is generally assumed that cytosine methylation is propagated in eukaryotes by enzymes that specifically methylate hemimethylated symmetrical sites (e.g., (5')CpGGpC(5') or (5')CpNpGGpNpC(5')). Although there is wide s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Selker EU,Freitag M,Kothe GO,Margolin BS,Rountree MR,Allis CD,Tamaru H

更新日期：2002-12-10 00:00:00

abstract：:From an analysis of the distributions of measures of transmission rates among hosts, we identify an empirical relationship suggesting that, typically, 20% of the host population contributes at least 80% of the net transmission potential, as measured by the basic reproduction number, R0. This is an example of a statist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woolhouse ME,Dye C,Etard JF,Smith T,Charlwood JD,Garnett GP,Hagan P,Hii JL,Ndhlovu PD,Quinnell RJ,Watts CH,Chandiwana SK,Anderson RM

更新日期：1997-01-07 00:00:00

abstract：:Protein misfolding and aggregation cause serious degenerative conditions such as Alzheimer's, Parkinson, and prion diseases. Damage to membranes is thought to be one of the mechanisms underlying cellular toxicity of a range of amyloid assemblies. Previous studies have indicated that amyloid fibrils can cause membrane ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milanesi L,Sheynis T,Xue WF,Orlova EV,Hellewell AL,Jelinek R,Hewitt EW,Radford SE,Saibil HR

更新日期：2012-12-11 00:00:00

abstract：:The family of WD40-repeat (WDR) proteins is one of the largest in eukaryotes, but little is known about their function in brain development. Among 26 WDR genes assessed, we found 7 displaying a major impact in neuronal morphology when inactivated in mice. Remarkably, all seven genes showed corpus callosum defects, inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kannan M,Bayam E,Wagner C,Rinaldi B,Kretz PF,Tilly P,Roos M,McGillewie L,Bär S,Minocha S,Chevalier C,Po C,Sanger Mouse Genetics Project.,Chelly J,Mandel JL,Borgatti R,Piton A,Kinnear C,Loos B,Adams DJ,Hérault Y,

更新日期：2017-10-31 00:00:00

abstract：:The herpes simplex virus DNA polymerase consists of two subunits--a catalytic subunit and an accessory subunit, UL42, that increases processivity. Mutations affecting the extreme C terminus of the catalytic subunit specifically disrupt subunit interactions and ablate virus replication, suggesting that new antiviral dr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Digard P,Williams KP,Hensley P,Brooks IS,Dahl CE,Coen DM

更新日期：1995-02-28 00:00:00

abstract：:Throughout three domains of life, alanyl-tRNA synthetases (AlaRSs) recognize a G3:U70 base pair in the acceptor stem of tRNAAla as the major identity determinant of tRNAAla The crystal structure of the archaeon Archaeoglobus fulgidus AlaRS in complex with tRNAAla provided the basis for G3:U70 recognition with residues...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chong YE,Guo M,Yang XL,Kuhle B,Naganuma M,Sekine SI,Yokoyama S,Schimmel P

更新日期：2018-07-17 00:00:00

abstract：:Chromogranin A (CGA) is a secretory protein present in the adrenal medulla and in a variety of endocrine organs. This protein may serve as precursor for pancreastatin (PST) and for other biologically active peptides. Recently, chromostatin (CST), a CGA derivative, has been identified that possesses high biological act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cetin Y,Aunis D,Bader MF,Galindo E,Jörns A,Bargsten G,Grube D

更新日期：1993-03-15 00:00:00

abstract：:We have examined the extent of tyrosine phosphorylation of talin, a component of the cytoskeleton localized in the focal adhesions and, therefore, a potential substrate of p60v-src, the transforming protein of Rous sarcoma virus. p60v-src is a tyrosine kinase that induces high levels of phosphotyrosine and the disorga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pasquale EB,Maher PA,Singer SJ

更新日期：1986-08-01 00:00:00

abstract：:Of two closely related species of geese, one, the greylag goose, lives in the Indian plains all year round, while the other, the bar-headed goose, lives at the Tibetan lakes and migrates across the Himalayas to winter in India. Another species, the Andean goose, lives in the High Andes all year round. Possession of a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jessen TH,Weber RE,Fermi G,Tame J,Braunitzer G

更新日期：1991-08-01 00:00:00

abstract：:T-cell tumors are characterized by inversions or translocations of chromosome 14. The breakpoints of these karyotypic abnormalities occur in chromosome bands 14q11 and 14q32--the same bands in which the T-cell receptor (TCR) alpha-chain and immunoglobulin heavy chain genes have been mapped, respectively. Patients with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baer R,Heppell A,Taylor AM,Rabbitts PH,Boullier B,Rabbitts TH

更新日期：1987-12-01 00:00:00

abstract：:Hepatitis A virus (HAV) infects ∼1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific monoclonal antibody, R1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Zhu L,Dang M,Hu Z,Gao Q,Yuan S,Sun Y,Zhang B,Ren J,Kotecha A,Walter TS,Wang J,Fry EE,Stuart DI,Rao Z

更新日期：2017-01-24 00:00:00

abstract：:The activated human Ha-ras oncogene was subjected to the control of the promoter region of the murine whey acidic protein (Wap) gene, which is expressed in mammary epithelial cells in response to lactogenic hormones. The Wap-ras gene was stably introduced into the mouse germ line of five transgenic mice (one male and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andres AC,Schönenberger CA,Groner B,Hennighausen L,LeMeur M,Gerlinger P

更新日期：1987-03-01 00:00:00

abstract：:The cellular actions of nerve growth factor (NGF) and epidermal growth factor (EGF) may be mediated by changes in protein phosphorylation. The tyrosine phosphorylation of two predominant proteins of molecular mass 40 and 42 kDa is seen in PC-12 cells treated with NGF or EGF, correlating with activation of a previously...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyasaka T,Sternberg DW,Miyasaka J,Sherline P,Saltiel AR

更新日期：1991-04-01 00:00:00

abstract：:Phage phi 29 DNA cannot be phosphorylated with polynucleotide kinase and [gamma-32P]ATP because of the presence of a viral protein covalently linked to the 5' termini. The 5' ends can, however, be made susceptible to phosphorylation by treatment with alkali and alkaline phosphatase. Restriction fragments Hpa II C and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Escarmís C,Salas M

更新日期：1981-03-01 00:00:00

abstract：:Multiple paleoclimate proxies are required for robust assessment of past hydroclimatic conditions. Currently, estimates of drought variability over the past several thousand years are based largely on tree-ring records. We produced a 1,500-y record of winter precipitation in the Pacific Northwest using a physical mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinman BA,Abbott MB,Mann ME,Stansell ND,Finney BP

更新日期：2012-07-17 00:00:00

abstract：:We report a signal-on, electronic DNA (E-DNA) sensor that is label-free and achieves a subpicomolar detection limit. The sensor, which is based on a target-induced strand displacement mechanism, is composed of a "capture probe" attached by its 5' terminus to a gold electrode and a 5' methylene blue-modified "signaling...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao Y,Lubin AA,Baker BR,Plaxco KW,Heeger AJ

更新日期：2006-11-07 00:00:00

abstract：:Numerous relatively short regions within intrinsically disordered proteins (IDPs) serve as molecular recognition elements (MoREs). They fold into ordered structures upon binding to their partner molecules. Currently, there is still a lack of in-depth understanding of how coupled binding and folding occurs in MoREs. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Chu X,Longhi S,Roche P,Han W,Wang E,Wang J

更新日期：2013-10-01 00:00:00

abstract：:A procedure is described to discover genes that are specifically expressed in human prostate. The procedure involves searching the expressed sequence tag (EST) database for genes that have many related EST sequences from human prostate cDNA libraries but none or few from nonprostate human libraries. The selected candi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vasmatzis G,Essand M,Brinkmann U,Lee B,Pastan I

更新日期：1998-01-06 00:00:00

abstract：:The corticotropin-releasing factor (CRF) ligand family has diverse effects on the CNS, including the modulation of the stress response. The ligands' effects are mediated by binding to CRF G protein-coupled receptors. We have determined the 3D NMR structure of the N-terminal extracellular domain (ECD1) of the mouse CRF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grace CR,Perrin MH,DiGruccio MR,Miller CL,Rivier JE,Vale WW,Riek R

更新日期：2004-08-31 00:00:00

abstract：:We describe preliminary studies of the pharmacokinetics, biodistribution, and excretion of an oligodeoxy-nucleotide phosphorothioate ([S]oligonucleotide) in mice. After either intravenous or intraperitoneal administration of a single dose (30 mg/kg of body weight), [S]oligonucleotide (35S-labeled at each internucleoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agrawal S,Temsamani J,Tang JY

更新日期：1991-09-01 00:00:00

abstract：:Induction of differentiation and apoptosis in cancer cells through ligands of nuclear hormone receptors (NHRs) is a novel and promising approach to cancer therapy. All-trans-retinoic acid (ATRA), an RA receptor-specific NHR ligand, is now used for selective cancers. The NHR, peroxisome proliferator-activated receptor ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elstner E,Müller C,Koshizuka K,Williamson EA,Park D,Asou H,Shintaku P,Said JW,Heber D,Koeffler HP

更新日期：1998-07-21 00:00:00

abstract：:Population outbreaks in tundra rodents have intrigued scientists for a century as a result of their spectacular appearances and their general lessons in ecology. One outstanding question that has led to competing hypotheses is why sympatric lemmings and voles differ in regularity and shape of their outbreaks. Lemming ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ims RA,Yoccoz NG,Killengreen ST

更新日期：2011-02-01 00:00:00

abstract：:We have determined the complete primary structure of human hemopexin, a plasma beta-glycoprotein that specifically binds one heme with high affinity and transports it to hepatocytes for salvage of the iron. Human hemopexin (Mr approximately equal to 63,000) consists of a single polypeptide chain containing 439 amino a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi N,Takahashi Y,Putnam FW

更新日期：1985-01-01 00:00:00

abstract：:The bacterial hibernating 100S ribosome is a poorly understood form of the dimeric 70S particle that has been linked to pathogenesis, translational repression, starvation responses, and ribosome turnover. In the opportunistic pathogen Staphylococcus aureus and most other bacteria, hibernation-promoting factor (HPF) ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basu A,Yap MN

更新日期：2017-09-26 00:00:00

abstract：:Transport of peptides across the membrane of the endoplasmic reticulum for assembly with MHC class I molecules is an essential step in antigen presentation to cytotoxic T cells. This task is performed by the major histocompatibility complex-encoded transporter associated with antigen processing (TAP). Using a combinat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uebel S,Kraas W,Kienle S,Wiesmüller KH,Jung G,Tampé R

更新日期：1997-08-19 00:00:00