Suppression of hippocampal slice excitability by 2-, 3-, and 4-methylpyridine.

Abstract:

:The present study assessed the effects of 2-, 3-, and 4-methylpyridine on rat hippocampal slice excitability. Tests of excitatory and inhibitory systems in area CA1 of the hippocampal slice were conducted over a period of 3 h postexposure. Following exposures of 100 microM 2-, 3-, or 4-methylpyridine, evoked population excitatory postsynaptic potential and population spike responses recorded in the cell body field of hippocampal area CA1 were slowly suppressed over the course of 3 h, whereas no effects on local inhibitory processes or latency of evoked responses were detected. No significant differences were observed between agents.

journal_name

Ecotoxicol Environ Saf

authors

Fountain SB,Teyler TJ

doi

10.1006/eesa.2000.2018

keywords:

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

301-5

issue

3

eissn

0147-6513

issn

1090-2414

pii

S0147-6513(00)92018-9

journal_volume

48

pub_type

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