Abstract:
:Mounting evidence suggests that compromised neurocognitive function is a core feature of schizophrenia. However, some studies have found neuropsychologically normal schizophrenia patients. To address this apparent contradiction, we blindly rated individual neuropsychological profiles of 75 schizophrenia patients and 91 control participants on the basis of methods developed by L. J. Seidman, S. V. Faraone, W. S. Kremen, J. R. Pepple, M. J. Lyons, and M. T. Tsuang (1993). Almost one-quarter of the patients were classified as neuropsychologically within normal limits (WNL). Despite significantly worse neuropsychological performance, WNL patients had higher estimated premorbid ability than did controls. Compared to a subset of controls matched on overall neuropsychological function, WNL patients had higher estimated premorbid ability and current IQs. Our results favor the view that even neuropsychologically normal schizophrenia patients have compromised cognitive function relative to their presumed expected or premorbid level of intellectual ability.
journal_name
J Abnorm Psycholjournal_title
Journal of abnormal psychologyauthors
Kremen WS,Seidman LJ,Faraone SV,Toomey R,Tsuang MTdoi
10.1037//0021-843x.109.4.743keywords:
subject
Has Abstractpub_date
2000-11-01 00:00:00pages
743-52issue
4eissn
0021-843Xissn
1939-1846journal_volume
109pub_type
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