The paradox of normal neuropsychological function in schizophrenia.

Abstract:

:Mounting evidence suggests that compromised neurocognitive function is a core feature of schizophrenia. However, some studies have found neuropsychologically normal schizophrenia patients. To address this apparent contradiction, we blindly rated individual neuropsychological profiles of 75 schizophrenia patients and 91 control participants on the basis of methods developed by L. J. Seidman, S. V. Faraone, W. S. Kremen, J. R. Pepple, M. J. Lyons, and M. T. Tsuang (1993). Almost one-quarter of the patients were classified as neuropsychologically within normal limits (WNL). Despite significantly worse neuropsychological performance, WNL patients had higher estimated premorbid ability than did controls. Compared to a subset of controls matched on overall neuropsychological function, WNL patients had higher estimated premorbid ability and current IQs. Our results favor the view that even neuropsychologically normal schizophrenia patients have compromised cognitive function relative to their presumed expected or premorbid level of intellectual ability.

journal_name

J Abnorm Psychol

authors

Kremen WS,Seidman LJ,Faraone SV,Toomey R,Tsuang MT

doi

10.1037//0021-843x.109.4.743

keywords:

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

743-52

issue

4

eissn

0021-843X

issn

1939-1846

journal_volume

109

pub_type

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