Abstract:
OBJECTIVE:The efficacy of medications, consisting of serotonin partial and specific reuptake blockers, and behavior therapy, consisting of exposure and response prevention in addition to social skills training, cognitive therapy, and habit reversal, in the treatment of obsessive-compulsive disorder are well documented. The purpose of the study was to explore if adding behavior therapy to medication would enhance treatment efficacy. METHODS:Ten children/adolescents who had not previously responded to behavior therapy were randomly assigned to two groups: fluvoxamine alone or fluvoxamine with behavior therapy. All 10 patients received fluvoxamine for 10 weeks-five continued solely on fluvoxamine for one year and five engaged in behavior therapy for 20 sessions along with fluvoxamine and then continued solely on medication until the end of the year. RESULTS:Eight of 10 patients improved significantly on fluvoxamine at week 10 on the primary outcome variable, the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS). According to the other measurements-National Institute of Mental Health-Global Obses-sive-Compulsive Scale, Clinical Global Impression-Improvement (assessing level of im-provement from week to week), and Clinical Global Impression-Severity of Illness Scale (as-sessing how ill the patient is from week to week)-improvement was not as evident. According to the CY-BOCS, those who received a combination of fluvoxamine and exposure with response prevention showed significantly more improvement than those who only took medication. At two-year follow-up, all patients continued to improve, with those in the combined approach improving more than those in the medication-alone group. CONCLUSIONS:Future studies should determine the specific effect of each treatment group, combined and singularly. Reasons for discrepancy in improvement ratings as noted by the different instruments are discussed. The addition of behavior therapy to fluvoxamine seems to enhance treatment efficacy, according to the CY-BOCS.
journal_name
J Child Adolesc Psychopharmacoljournal_title
Journal of child and adolescent psychopharmacologyauthors
Neziroglu F,Yaryura-Tobias JA,Walz J,McKay Ddoi
10.1089/cap.2000.10.295keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
295-306issue
4eissn
1044-5463issn
1557-8992journal_volume
10pub_type
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,meta分析,评审
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pub_type: 临床试验,杂志文章
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更新日期:2009-12-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
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更新日期:2007-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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更新日期:2009-02-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章
doi:10.1089/cap.1999.9.99
更新日期:1999-01-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2005-04-01 00:00:00
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更新日期:1998-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2014-11-01 00:00:00
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更新日期:2005-08-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2009-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-10-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-08-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-08-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1089/cap.2015.0192
更新日期:2016-10-01 00:00:00